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Found 393 with Last Name = 'gu' and Initial = 'xh'
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50366764(CHEMBL1790045 | MCL-117)
Affinity DataKi:  0.00300nMAssay Description:Binding affinity towards guinea pig Opioid receptor kappa 1 using radioligand [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50366764(CHEMBL1790045 | MCL-117)
Affinity DataKi:  0.00320nMAssay Description:Binding affinity towards Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50451302(CHEMBL2115245)
Affinity DataKi:  0.00480nMAssay Description:Binding affinity towards Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602306(CHEMBL5208487)
Affinity DataKi:  0.0260nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135800((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Affinity DataKi:  0.0340nMAssay Description:Inhibitory activity against Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]U-69593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM295665((S)-2-((2-((S)-4-(difluoromethyl)- 2-oxooxazolidin...)
Affinity DataKi:  0.0340nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50451302(CHEMBL2115245)
Affinity DataKi:  0.0370nMAssay Description:Binding affinity towards guinea pig Opioid receptor kappa 1 using radioligand [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602320(CHEMBL5199631)
Affinity DataKi:  0.0420nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50602324(CHEMBL5198796)
Affinity DataKi:  0.0430nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135806(CHEMBL147511 | MCL-144 | di[17-cyclobutylmethyl-(1...)
Affinity DataKi:  0.0500nMAssay Description:Inhibitory activity against Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]U-69593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM295669((S)-2-cyclopropyl-2-((2-((S)-4- (fluoromethyl)-2-o...)
Affinity DataKi:  0.0510nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50602323(CHEMBL5209168)
Affinity DataKi:  0.0530nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135800((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Affinity DataKi:  0.0530nMAssay Description:Binding affinity towards Opioid receptor kappa 1 in guinea pig brain membranes using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Alcohol And Drug Abuse Research Center

Curated by ChEMBL
LigandPNGBDBM50106857(3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2-car...)
Affinity DataKi:  0.0600nMAssay Description:Ability to displace [3H]- paroxetine from Serotonin transporter in rat cerebral cortical homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM475607(US10851091, Compound 103)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135800((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Affinity DataKi:  0.0600nMAssay Description:Inhibitory activity against Opioid receptor mu 1 in chinese Hamster Ovary (CHO) cells membranes was determined using [3H]-DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602305(CHEMBL5209048)
Affinity DataKi:  0.0620nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135808((-)-3-Hydroxy-N-cyclobutylmethylmorphinan S(+)-Man...)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity towards Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135796(1-[17-cyclobutylmethyl-(1R,9R,10R)-17-azatetracycl...)
Affinity DataKi:  0.0700nMAssay Description:Inhibitory activity against Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]U-69593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135798(CHEMBL433697 | di[17-cyclobutylmethyl-(10R)-17-aza...)
Affinity DataKi:  0.0800nMAssay Description:Inhibitory activity against Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]U-69593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135797(CHEMBL146756 | di[17-cyclobutylmethyl-(1R,9R,10R)-...)
Affinity DataKi:  0.0800nMAssay Description:Inhibitory activity against Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]U-69593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135808((-)-3-Hydroxy-N-cyclobutylmethylmorphinan S(+)-Man...)
Affinity DataKi:  0.0800nMAssay Description:Inhibitory activity against Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]U-69593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105498(17-(3-fluoropropyl)-(1R,9R,10R)-17-azatetracyclo[7...)
Affinity DataKi:  0.0830nMAssay Description:Binding affinity towards Opioid receptor kappa 1 in guinea pig brain membranes using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50434806(2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-y...)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135806(CHEMBL147511 | MCL-144 | di[17-cyclobutylmethyl-(1...)
Affinity DataKi:  0.0900nMAssay Description:Inhibitory activity against Opioid receptor mu 1 in chinese Hamster Ovary (CHO) cells membranes was determined using [3H]-DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135800((-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandel...)
Affinity DataKi:  0.0920nMAssay Description:Binding affinity towards Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105477(17-(2-methoxyethyl)-(1R,9R,10R)-17-azatetracyclo[7...)
Affinity DataKi:  0.0940nMAssay Description:Binding affinity towards guinea pig Opioid receptor kappa 1 using radioligand [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602328(CHEMBL5205438)
Affinity DataKi:  0.0950nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50602326(CHEMBL5181348)
Affinity DataKi:  0.0970nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50602331(CHEMBL5182371)
Affinity DataKi:  0.100nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135801(CHEMBL413512 | di[17-cyclopropylmethyl-(10R)-17-az...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]U-69593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of EGFR deletion (746 to 750 residues) mutant (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50602304(CHEMBL5182339)
Affinity DataKi:  0.107nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105477(17-(2-methoxyethyl)-(1R,9R,10R)-17-azatetracyclo[7...)
Affinity DataKi:  0.110nMAssay Description:Binding affinity towards Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135808((-)-3-Hydroxy-N-cyclobutylmethylmorphinan S(+)-Man...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity towards Opioid receptor delta 1 in guinea pig brain membranes using [3H]naltrindole as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105496(17-phenethyl-(1R,9R,10R)-17-azatetracyclo[7.5.3.01...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity towards Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105474(17-(2-furylmethyl)-(1R,9R,10R)-17-azatetracyclo[7....)
Affinity DataKi:  0.130nMAssay Description:Binding affinity towards guinea pig Opioid receptor kappa 1 using radioligand [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135801(CHEMBL413512 | di[17-cyclopropylmethyl-(10R)-17-az...)
Affinity DataKi:  0.140nMAssay Description:Inhibitory activity against Opioid receptor mu 1 in chinese Hamster Ovary (CHO) cells membranes was determined using [3H]-DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50602321(CHEMBL5202305)
Affinity DataKi:  0.150nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50602329(CHEMBL5189517)
Affinity DataKi:  0.157nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105479(3-[5-hydroxy-(1R,9R,10R)-17-azatetracyclo[7.5.3.01...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity towards Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135798(CHEMBL433697 | di[17-cyclobutylmethyl-(10R)-17-aza...)
Affinity DataKi:  0.160nMAssay Description:Inhibitory activity against Opioid receptor mu 1 in chinese Hamster Ovary (CHO) cells membranes was determined using [3H]-DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105495(17-isobutyl-(1R,9R,10R)-17-azatetracyclo[7.5.3.01,...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity towards Opioid receptor kappa 1 in guinea pig brain membranes using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105491(17-allyl-(1R,9R,10R)-17-azatetracyclo[7.5.3.01,10....)
Affinity DataKi:  0.160nMAssay Description:Binding affinity towards guinea pig Opioid receptor kappa 1 using radioligand [3H]U-69593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135809(CHEMBL150061 | MCL-143 | di[17-cyclobutylmethyl-(9...)
Affinity DataKi:  0.170nMAssay Description:Inhibitory activity against Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes was determined using [3H]U-69593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105498(17-(3-fluoropropyl)-(1R,9R,10R)-17-azatetracyclo[7...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity towards Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM295676(US10851091, U.S. Pat. No. 8,242,104 No. 486 | US82...)
Affinity DataKi:  0.188nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:3PS as substrate in presence of ATP measured after 120 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50141636(CHEMBL3758502)
Affinity DataKi:  0.200nMAssay Description:Inhibition of EGFR deletion (746 to 750 residues) mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50135797(CHEMBL146756 | di[17-cyclobutylmethyl-(1R,9R,10R)-...)
Affinity DataKi:  0.200nMAssay Description:Inhibitory activity against Opioid receptor mu 1 in chinese Hamster Ovary (CHO) cells membranes was determined using [3H]-DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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