Affinity DataIC50: 0.120nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.220nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
Affinity DataIC50: 0.270nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.520nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
Affinity DataIC50: 0.520nMAssay Description:Inhibitory activity of the compound against squalene synthase (SQS) obtained from HepG2 cellsMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.580nMAssay Description:Inhibitory activity against I-Eotaxin binding to human CCR3 receptorsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.660nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.730nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.730nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Binding affinity of the compound in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]-Tyr14-nociceptinMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity of the compound against squalene synthase (SQS) obtained from HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Banyu Tsukuba Research Institute
Curated by ChEMBL
Banyu Tsukuba Research Institute
Curated by ChEMBL
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute
Curated by ChEMBL
Tsukuba Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute
Curated by ChEMBL
Tsukuba Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human ORL1 receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibitory activity of the compound against squalene synthase (SQS) obtained from HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Banyu Tsukuba Research Institute
Curated by ChEMBL
Banyu Tsukuba Research Institute
Curated by ChEMBL
Affinity DataIC50: 4.70nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Banyu Tsukuba Research Institute
Curated by ChEMBL
Banyu Tsukuba Research Institute
Curated by ChEMBL
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Rattus norvegicus)
Tsukuba Research Institute
Curated by ChEMBL
Tsukuba Research Institute
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of Farnesyltransferase from rat brainMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.More data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Displacement of [125I]Tyr14-NC from human ORL1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Inhibition of [125I]Tyr14-nociceptin binding to human Opioid receptor like 1 (opioid receptor like 1) in CHO cellsMore data for this Ligand-Target Pair