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Found 937 with Last Name = 'seki' and Initial = 'y'
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Kyushu Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50425950(CHEMBL2311561 | Isoniazid-NAD)
Affinity DataKi:  0.75nMAssay Description:Inhibition of Mycobacterium tuberculosis InhAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM86674(ATC0175)
Affinity DataKi:  7.23nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM86674(ATC0175)
Affinity DataKi:  9.66nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM86673(ATC 0065 | ATC0065 | CAS_510732-84-0)
Affinity DataKi:  15.7nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM86674(ATC0175)
Affinity DataKi:  16.9nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM86673(ATC 0065 | ATC0065 | CAS_510732-84-0)
Affinity DataKi:  266nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate kinase(Mycobacterium tuberculosis)
Kyushu Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50131916(Phosphoric acid mono-[3-azidomethyl-5-(5-methyl-2,...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis thymidine monophosphate kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate kinase(Mycobacterium tuberculosis)
Kyushu Institute of Technology

Curated by ChEMBL
LigandPNGBDBM50131914(Phosphoric acid mono-[3-aminomethyl-5-(5-methyl-2,...)
Affinity DataKi:  1.05E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis thymidine monophosphate kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649820(US20240043403, Example 57)
Affinity DataIC50:  0.420nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649819(US20240043403, Example 56)
Affinity DataIC50:  0.890nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
National Institute of Health Sciences

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of estrogen receptor alpha (unknown origin)-SRC1 coactivator interaction incubated for 1 hr by receptor cofactor assay system based methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074846(CHEMBL545597 | [3-(4-Methoxy-3-phenethyloxy-phenyl...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074867((2-{4-Methoxy-3-[2-(4-methoxy-phenyl)-ethoxy]-phen...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074866((2-{3-[2-(4-Fluoro-phenyl)-ethoxy]-4-methoxy-pheny...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166561(CHEMBL195380 | Naphthalene-1-sulfonic acid {4-[(4-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity against constitutively activated human Neuropeptide Y receptor Y5 stransiently expressed in COS-1 cells using [125I]-PYYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50170660(CHEMBL190883 | CHEMBL521582 | N,N-dipropyl-2-[4-me...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649841(US20240043403, Example 78)
Affinity DataIC50:  1.30nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649881(US20240043403, Example 118)
Affinity DataIC50:  1.40nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649857(US20240043403, Example 94)
Affinity DataIC50:  1.40nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074859((2-{3-[2-(3-Chloro-phenyl)-ethoxy]-4-methoxy-pheny...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166554(CHEMBL192266 | N-{4-[(4-Amino-quinazolin-2-ylamino...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory activity against constitutively activated human Neuropeptide Y receptor Y5 stransiently expressed in COS-1 cells using [125I]-PYYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074828(CHEMBL11290 | {2-[3-Methoxy-2-(3-phenyl-propoxy)-p...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074827(CHEMBL542298 | Hexyl-[2-(4-methoxy-3-phenethyloxy-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649849(US20240043403, Example 125 | US20240043403, Exampl...)
Affinity DataIC50:  1.80nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50170193(CHEMBL360081 | N-[4-(4-Dimethylamino-quinazolin-2-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50302559(CHEMBL578049 | N-(cis-4-{[4-(Dimethylamino)-5-meth...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649847(US20240043403, Example 84)
Affinity DataIC50:  2.10nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50302561(CHEMBL568208 | N-((cis)-4-(4-(dimethylamino)-5,6-d...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166552(4-Bromo-N-{4-[(4-dimethylamino-quinazolin-2-ylamin...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory activity against constitutively activated human Neuropeptide Y receptor Y5 stransiently expressed in COS-1 cells using [125I]-PYYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50302552(CHEMBL578166 | N-((cis)-4-(4-(dimethylamino)-6-met...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50166555(4-Bromo-N-{4-[(4-dimethylamino-quinazolin-2-ylamin...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory activity against constitutively activated human Neuropeptide Y receptor Y5 stransiently expressed in COS-1 cells using [125I]-PYYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50170189(4-Bromo-N-{4-[(4-dimethylamino-quinazolin-2-ylamin...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]PYY as radioligand expressed in COS-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402166(CHEMBL2207988)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074839(CHEMBL542047 | [2-(3-Methoxy-2-phenethyloxy-phenyl...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649856(US20240043403, Example 93)
Affinity DataIC50:  2.80nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649849(US20240043403, Example 125 | US20240043403, Exampl...)
Affinity DataIC50:  2.90nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074865(CHEMBL542295 | [2-(4-Methoxy-3-phenethyloxy-phenyl...)
Affinity DataIC50:  2.90nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50302555(CHEMBL567993 | N-((cis)-4-(4-(dimethylamino)-5-met...)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402256(CHEMBL2204786)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PI3Kgamma using phosphatidylinositol as substrate and [33gammaP]ATP after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402251(CHEMBL2204791)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PI3Kgamma using phosphatidylinositol as substrate and [33gammaP]ATP after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402251(CHEMBL2204791)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074869(4-(2-Dipropylamino-ethyl)-2-phenethyloxy-phenol; h...)
Affinity DataIC50:  3.10nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649809(US20240043403, Example 46)
Affinity DataIC50:  3.10nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649797(US20240043403, Example 34)
Affinity DataIC50:  3.10nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381818(CHEMBL2023644)
Affinity DataIC50:  3.20nMAssay Description:Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381815(CHEMBL2023641)
Affinity DataIC50:  3.20nMAssay Description:Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381818(CHEMBL2023644)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase delta(Human)
Astellas Pharma

US Patent
LigandPNGBDBM649792(US20240043403, Example 122 | US20240043403, Exampl...)
Affinity DataIC50:  3.20nMAssay Description:To a 384-well plate (Greiner Bio-One Co., Ltd.), 3 μL of a DGK ξ enzyme dissolved in an assay buffer (40 mM Tris-HCl pH 7.5, 10 mM MgCl2, 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50170191(CHEMBL182150 | N-((cis)-4-(4-(dimethylamino)quinaz...)
Affinity DataIC50:  3.40nMAssay Description:Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381819(CHEMBL2023645)
Affinity DataIC50:  3.40nMAssay Description:Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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