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Found 36 with Last Name = 'tsapko' and Initial = 'y'
TargetUrea transporter 1(Rattus norvegicus (Rat))TBA
LigandPNGBDBM50607931(CHEMBL5289033)
Affinity DataIC50:  200nMAssay Description:Inhibition of UT-B in Sprague-Dawley rat erythrocyte incubated for 6 min by erythrocyte osmotic lysis based high-throughput screening assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSolute carrier family 12 member 2(Homo sapiens (Human))TBA
LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50:  240nMAssay Description:Inhibition of NKCC1 in human HT-29 cells assessed as inhibition of rubidium uptake incubated for 20 min by atomic absorption spectroscopyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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TargetUrea transporter 1(Rattus norvegicus (Rat))TBA
LigandPNGBDBM50607933(CHEMBL5269927)
Affinity DataIC50:  280nMAssay Description:Inhibition of UT-B in Sprague-Dawley rat erythrocyte incubated for 6 min by erythrocyte osmotic lysis based high-throughput screening assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetUrea transporter 1(Mus musculus)TBA
LigandPNGBDBM50607929(CHEMBL5279934)
Affinity DataIC50:  690nMAssay Description:Inhibition of UT-B in mouse erythrocyte incubated for 10 mins by stopped-flow light scattering assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetUrea transporter 1(Rattus norvegicus (Rat))TBA
LigandPNGBDBM50512227(CHEMBL4454312)
Affinity DataIC50:  800nMAssay Description:Inhibition of UT-B in rat erythrocyte by stopped-flow light scattering assayMore data for this Ligand-Target Pair
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TargetUrea transporter 1(Rattus norvegicus (Rat))TBA
LigandPNGBDBM50512247(CHEMBL4545692)
Affinity DataIC50:  900nMAssay Description:Inhibition of rat UT-B expressed in MDCK cells assessed as inhibition of urea transport incubated for 30 minsMore data for this Ligand-Target Pair
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TargetUrea transporter 1(Mus musculus)TBA
LigandPNGBDBM50134204(CHEMBL3740772)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of UT-B in mouse erythrocyte incubated for 15 mins by erythrocyte osmotic lysis assayMore data for this Ligand-Target Pair
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TargetSolute carrier family 12 member 2(Homo sapiens (Human))TBA
LigandPNGBDBM25903(3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |...)
Affinity DataIC50:  1.54E+3nMAssay Description:Inhibition of NKCC1 in human HT-29 cells assessed as inhibition of rubidium uptake incubated for 20 min by atomic absorption spectroscopyMore data for this Ligand-Target Pair
TargetUrea transporter 1(Mus musculus)TBA
LigandPNGBDBM50607929(CHEMBL5279934)
Affinity DataIC50:  1.61E+3nMAssay Description:Inhibition of UT-B in mouse erythrocyteMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAquaporin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50166561(CHEMBL195380 | Naphthalene-1-sulfonic acid {4-[(4-...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human AQP1 water channel expressed in CHO cells incubated for 10 mins by FLIPR Tetra assayMore data for this Ligand-Target Pair
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TargetUrea transporter 1(Mus musculus)TBA
LigandPNGBDBM50607934(CHEMBL1374572)
Affinity DataIC50:  4.15E+3nMAssay Description:Inhibition of UT-B in mouse erythrocyteMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPendrin(Mus musculus)TBA
LigandPNGBDBM50607937(CHEMBL4515533)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of mouse Pendrin stably expressed in FRT cells with YFP assessed as inhibition of pendrin mediated Cl-/NO3- exchange by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAquaporin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50607942(CHEMBL5280011)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of human AQP1 water channel expressed in CHO cells incubated for 10 mins by FLIPR Tetra assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetPendrin(Mus musculus)TBA
LigandPNGBDBM50607937(CHEMBL4515533)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of mouse Pendrin stably expressed in FRT cells with YFP assessed as inhibition of pendrin mediated Cl-/SCN- exchange by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAquaporin-1(Homo sapiens (Human))TBA
LigandPNGBDBM178092({[7-(2,4-dichlorophenyl)-5-fluoro-2,3-dihydro-1-be...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of human AQP1 water channel expressed in CHO cells incubated for 10 mins by FLIPR Tetra assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUrea transporter 1(Mus musculus)TBA
LigandPNGBDBM50607931(CHEMBL5289033)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of UT-B in C57BL/6J mouse erythrocyte incubated for 6 min by erythrocyte osmotic lysis based high-throughput screening assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetUrea transporter 1(Mus musculus)TBA
LigandPNGBDBM50607933(CHEMBL5269927)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of UT-B in C57BL/6J mouse erythrocyte incubated for 6 min by erythrocyte osmotic lysis based high-throughput screening assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPendrin(Mus musculus)TBA
LigandPNGBDBM50607937(CHEMBL4515533)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of mouse Pendrin stably expressed in FRT cells with YFP assessed as inhibition of pendrin mediated Cl-/HCO3- exchange by fluorescence assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAquaporin-4(Rattus norvegicus)TBA
LigandPNGBDBM25902(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of rat AQP4 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swelling incubated for 1 to ...More data for this Ligand-Target Pair
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TargetAquaporin-1(Homo sapiens (Human))TBA
LigandPNGBDBM178093([7-(2,4-dichlorophenyl)-5-fluoro-2,3-dihydro-1-ben...)
Affinity DataIC50:  1.52E+4nMAssay Description:Inhibition of human AQP1 water channel expressed in CHO cells incubated for 10 mins by FLIPR Tetra assayMore data for this Ligand-Target Pair
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TargetUrea transporter 1(Mus musculus)TBA
LigandPNGBDBM115182(N‐(4‐ethoxyphenyl)‐8‐metho...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of UT-B in mouse erythrocyte incubated for 15 mins by erythrocyte osmotic lysis assayMore data for this Ligand-Target Pair
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TargetAquaporin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50607939(CHEMBL1537920)
Affinity DataIC50:  1.75E+4nMAssay Description:Inhibition of human AQP1 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swelling incubated for 1 t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAquaporin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50607938(CHEMBL5280895)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human AQP1 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swelling incubated for 1 t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAquaporin-4(Rattus norvegicus)TBA
LigandPNGBDBM50607938(CHEMBL5280895)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of rat AQP4 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swelling incubated for 1 to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAquaporin-1(Homo sapiens (Human))TBA
LigandPNGBDBM178094({[7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-be...)
Affinity DataIC50:  2.94E+4nMAssay Description:Inhibition of human AQP1 water channel expressed in CHO cells incubated for 10 mins by FLIPR Tetra assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUrea transporter 1(Mus musculus)TBA
LigandPNGBDBM50607935(CHEMBL5274899)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of UT-B in mouse erythrocyte incubated for 15 mins by erythrocyte osmotic lysis assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAquaporin-4(Rattus norvegicus)TBA
LigandPNGBDBM25903(3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of rat AQP4 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swelling incubated for 1 to ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUrea transporter 1(Rattus norvegicus (Rat))TBA
LigandPNGBDBM50607930(CHEMBL5276686)
Affinity DataIC50:  4.70E+5nMAssay Description:Inhibition of UT-B in Sprague-Dawley rat erythrocyte incubated for 6 min by erythrocyte osmotic lysis based high-throughput screening assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetUrea transporter 1(Mus musculus)TBA
LigandPNGBDBM50607930(CHEMBL5276686)
Affinity DataIC50:  2.01E+6nMAssay Description:Inhibition of UT-B in C57BL/6J mouse erythrocyte incubated for 6 min by erythrocyte osmotic lysis based high-throughput screening assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetUrea transporter 1(Mus musculus)TBA
LigandPNGBDBM50607932(CHEMBL5288362)
Affinity DataIC50:  3.18E+6nMAssay Description:Inhibition of UT-B in C57BL/6J mouse erythrocyte incubated for 6 min by erythrocyte osmotic lysis based high-throughput screening assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetUrea transporter 1(Rattus norvegicus (Rat))TBA
LigandPNGBDBM50607932(CHEMBL5288362)
Affinity DataIC50:  5.63E+6nMAssay Description:Inhibition of UT-B in Sprague-Dawley rat erythrocyte incubated for 6 min by erythrocyte osmotic lysis based high-throughput screening assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAquaporin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50607940(CHEMBL5282904)
Affinity DataIC50:  1.70E+7nMAssay Description:Inhibition of human AQP1 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swelling incubated for 1 t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetUrea transporter 1(Mus musculus)TBA
LigandPNGBDBM50607936(CHEMBL3189044)
Affinity DataIC50:  2.30E+7nMAssay Description:Inhibition of UT-B in mouse erythrocyte incubated for 15 mins by erythrocyte osmotic lysis assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAquaporin-1(Homo sapiens (Human))TBA
LigandPNGBDBM94509((E)-2-butenedioic acid;2-[4-tert-butyl-1-[(4-fluor...)
Affinity DataEC50:  4.80E+4nMAssay Description:Inhibition of AQP1 water channel in human erythrocyte by stopped-flow spectrometryMore data for this Ligand-Target Pair
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TargetAquaporin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50607943(CHEMBL1740905)
Affinity DataEC50:  2.00E+4nMAssay Description:Inhibition of AQP1 water channel in human erythrocyte by stopped-flow spectrometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAquaporin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50607941(CHEMBL5268096)
Affinity DataEC50:  3.30E+3nMAssay Description:Agonist activity at human AQP1 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swellingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed