Affinity DataKi: 6nMAssay Description:Inhibition of human AICARFTMore data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Binding constant at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:Binding constant at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
Affinity DataKi: 780nMAssay Description:Binding constant at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
Affinity DataKi: 3.69E+3nMAssay Description:Binding constant at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Binding constant at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
Affinity DataIC50: <5nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: <5nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: <5nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 608nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 680nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 723nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 730nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 790nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 870nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 920nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 980nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Activity towards binding at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 7.60E+3nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 7.70E+3nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 1.81E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+4nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 3.48E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+4nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+4nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 7.10E+4nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human full length N-terminal His-tagged AICARFT expressed in Escherichia coli BL21 (DE3) using ZMP/10-formyltetrahydrofolate as substra...More data for this Ligand-Target Pair
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Eli Lilly
Curated by ChEMBL
Eli Lilly
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MTHFD2 (unknown origin) using NAD/5,10-methylene THF as substrate after 30 mins by HPLC methodMore data for this Ligand-Target Pair
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial(Homo sapiens)
Eli Lilly
Curated by ChEMBL
Eli Lilly
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MTHFD2L (unknown origin) using NAD/5,10-methylene THF as substrate after 2 hrs by HPLC methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MTHFD1 (unknown origin) using NADP/5,10-methylene THF as substrate after 30 mins by HPLC methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SHMT1 (unknown origin) using serine/THF as substrate after 50 mins by HPLC methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of thymidylate synthase (unknown origin) using dUMP/5,10-methylene THF as substrate after 1 hr by mass spectrometric methodMore data for this Ligand-Target Pair