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Found 743 with Last Name = 'asberom' and Initial = 't'
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110557(CHEMBL352380 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110543(CHEMBL167396 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110555(CHEMBL164935 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110551(CHEMBL352291 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110540(Benzoic acid 2-[4-((R)-4-{(S)-1-[4-(benzo[1,3]diox...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110546(CHEMBL165377 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110542(CHEMBL167816 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190709(US9181236, 13)
Affinity DataKi:  0.300nM ΔG°:  -55.3kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190708(US9181236, 12)
Affinity DataKi:  0.300nM ΔG°:  -55.3kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110553(CHEMBL349142 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110547(CHEMBL165035 | [4-((R)-3-Methyl-4-{(S)-1-[4-(tolue...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190697(US9181236, 1)
Affinity DataKi:  0.400nM ΔG°:  -54.5kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190700(US9181236, 4)
Affinity DataKi:  0.5nM ΔG°:  -54.0kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110550((2-Amino-phenyl)-[4-((R)-4-{(S)-1-[4-(benzo[1,3]di...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110556(CHEMBL354534 | [4-((R)-4-{(S)-1-[4-(2,4-Dimethoxy-...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190711(US9181236, 15)
Affinity DataKi:  0.600nM ΔG°:  -53.5kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110530(CHEMBL349720 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190714(US9181236, 18)
Affinity DataKi:  0.800nM ΔG°:  -52.8kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110559(CHEMBL110744 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50103087(CHEMBL305026 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190699(US9181236, 3)
Affinity DataKi:  0.900nM ΔG°:  -52.5kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190773(US9181236, 62g)
Affinity DataKi:  0.900nM ΔG°:  -52.5kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190761(US9181236, 58)
Affinity DataKi:  1nM ΔG°:  -52.2kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190796(US9181236, 64)
Affinity DataKi:  1nM ΔG°:  -52.2kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110560(CHEMBL165434 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  1nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190727(US9181236, 31)
Affinity DataKi:  1.20nM ΔG°:  -51.8kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190708(US9181236, 12)
Affinity DataKi:  1.30nM ΔG°:  -51.6kJ/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190784(US9181236, 63c)
Affinity DataKi:  1.30nM ΔG°:  -51.6kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110552(CHEMBL353842 | [4-((R)-4-{(S)-1-[4-(Benzo[1,3]diox...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190717(US9181236, 21)
Affinity DataKi:  1.30nM ΔG°:  -51.6kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190732(US9181236, 35a)
Affinity DataKi:  1.40nM ΔG°:  -51.4kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190787(US9181236, 63f)
Affinity DataKi:  1.5nM ΔG°:  -51.2kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190713(US9181236, 17)
Affinity DataKi:  1.5nM ΔG°:  -51.2kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190729(US9181236, 33)
Affinity DataKi:  1.60nM ΔG°:  -51.0kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190697(US9181236, 1)
Affinity DataKi:  1.60nM ΔG°:  -51.0kJ/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190808(US9181236, 75)
Affinity DataKi:  1.70nM ΔG°:  -50.9kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190769(US9181236, 62c)
Affinity DataKi:  1.80nM ΔG°:  -50.7kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110544(CHEMBL354461 | [4-((R)-3-Methyl-4-{(S)-1-[4-(3-tri...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190702(US9181236, 6)
Affinity DataKi:  1.90nM ΔG°:  -50.6kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190701(US9181236, 5)
Affinity DataKi:  1.90nM ΔG°:  -50.6kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190750(US9181236, 48)
Affinity DataKi:  2nM ΔG°:  -50.5kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190745(US9181236, 44)
Affinity DataKi:  2nM ΔG°:  -50.5kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190710(US9181236, 14)
Affinity DataKi:  2.10nM ΔG°:  -50.4kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190726(US9181236, 30)
Affinity DataKi:  2.10nM ΔG°:  -50.4kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190710(US9181236, 14)
Affinity DataKi:  2.20nM ΔG°:  -50.2kJ/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50 values for inhibitors of the soluble human BACE1 catalytic domain. This assay mo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190778(US9181236, 62l)
Affinity DataKi:  2.20nM ΔG°:  -50.2kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190809(US9181236, 76a (isomeric sample 1) | US9181236, 76...)
Affinity DataKi:  2.40nM ΔG°:  -50.0kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190705(US9181236, 9)
Affinity DataKi:  2.5nM ΔG°:  -49.9kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110558(CHEMBL167629 | [4-((R)-4-{(S)-1-[4-(4-Methoxy-benz...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]-N-methylscopolamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM190783(US9181236, 63b)
Affinity DataKi:  2.70nM ΔG°:  -49.7kJ/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...More data for this Ligand-Target Pair
In DepthDetails US Patent
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