TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 0.900nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 2.40nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 2.60nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 2.80nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 7.70nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 31nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 62nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 72nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 260nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 270nMAssay Description:Inhibition of biotinylated human FXIa assessed as inhibition of p-nitroaniline release using Pyr-Pro-Arg-pNA as substrate measured for 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 145nMpH: 7.5 T: 2°CAssay Description:ATP-site competition binding assay using Mps1 Kinase inhibitors in LanthaScreen Eu time-resolved FRET (TR-FRET) technology from Invitrogen.More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Northern Kentucky University
Curated by ChEMBL
Northern Kentucky University
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of xanthine oxidase (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 367nMpH: 7.5 T: 2°CAssay Description:ATP-site competition binding assay using Mps1 Kinase inhibitors in LanthaScreen Eu time-resolved FRET (TR-FRET) technology from Invitrogen.More data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 920nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Northern Kentucky University
Curated by ChEMBL
Northern Kentucky University
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Northern Kentucky University
Curated by ChEMBL
Northern Kentucky University
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Northern Kentucky University
Curated by ChEMBL
Northern Kentucky University
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Northern Kentucky University
Curated by ChEMBL
Northern Kentucky University
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Northern Kentucky University
Curated by ChEMBL
Northern Kentucky University
Curated by ChEMBL
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Northern Kentucky University
Curated by ChEMBL
Northern Kentucky University
Curated by ChEMBL
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Northern Kentucky University
Curated by ChEMBL
Northern Kentucky University
Curated by ChEMBL
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Northern Kentucky University
Curated by ChEMBL
Northern Kentucky University
Curated by ChEMBL
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair