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Found 686 with Last Name = 'aubert' and Initial = 'j'
TargetEndothelin-1 receptor(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50051007((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)
Affinity DataKi:  0.0430nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]-diprenorphine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)
Affinity DataKi:  0.0440nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)
Affinity DataKi:  0.0540nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463758(CHEMBL4250302)
Affinity DataKi:  0.0560nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463741(CHEMBL4239232)
Affinity DataKi:  0.0570nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093965(CHEMBL86324 | N-Methyl-N-((S)-1-phenyl-2-pyrrolidi...)
Affinity DataKi:  0.0580nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093965(CHEMBL86324 | N-Methyl-N-((S)-1-phenyl-2-pyrrolidi...)
Affinity DataKi:  0.0580nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50090002(CHEMBL411003 | Dynorphin A (1-11)-NH2H-Tyr-Gly-Gly...)
Affinity DataKi:  0.0590nMAssay Description:In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463759(CHEMBL4237636)
Affinity DataKi:  0.0630nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093964(CHEMBL313484 | N-Methyl-N-((S)-1-phenyl-2-pyrrolid...)
Affinity DataKi:  0.0640nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093969(CHEMBL82919 | N-Methyl-2-(3-nitro-phenyl)-N-((S)-1...)
Affinity DataKi:  0.0650nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50090002(CHEMBL411003 | Dynorphin A (1-11)-NH2H-Tyr-Gly-Gly...)
Affinity DataKi:  0.0740nMAssay Description:Binding affinity towards cloned human Opioid receptor kappa 1 in CHO cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463739(CHEMBL4237803)
Affinity DataKi:  0.0750nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093958(2-(2-Amino-3,4-dichloro-phenyl)-N-methyl-N-((S)-1-...)
Affinity DataKi:  0.0860nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093966(2-(3,4-Dichloro-2-nitro-phenyl)-N-methyl-N-((S)-1-...)
Affinity DataKi:  0.0910nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093970(2-(3,4-Dichloro-2-dimethanesulfonylamino-phenyl)-N...)
Affinity DataKi:  0.0960nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463736(CHEMBL4251203)
Affinity DataKi:  0.0970nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093962(CHEMBL87306 | N-Methyl-N-((S)-1-phenyl-2-pyrrolidi...)
Affinity DataKi:  0.130nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463756(CHEMBL4246561)
Affinity DataKi:  0.150nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50090003(CHEMBL405190 | Tyr-Gly-[D-Ala]-Phe-Leu-Arg-Arg-Ile...)
Affinity DataKi:  0.150nMAssay Description:Human Opioid receptor kappa 1 mediated stimulation of [35S]- GTPgammaS binding in CHO cells (Agonist potency).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50377009(CHEMBL257140)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50010702(CHEMBL411557 | DYNORPHIN(1-17)-OH | Dynorphin A (1...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50377005(CHEMBL402135)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50128091(CHEMBL265813 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg...)
Affinity DataKi:  0.230nMAssay Description:In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463750(CHEMBL4241807)
Affinity DataKi:  0.230nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  0.270nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463753(CHEMBL4250739)
Affinity DataKi:  0.270nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463752(CHEMBL4247370)
Affinity DataKi:  0.270nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463754(CHEMBL4240635)
Affinity DataKi:  0.280nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463740(CHEMBL4251365)
Affinity DataKi:  0.290nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50377016(CHEMBL402820)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160834(CHEMBL183248 | N-[(S)-1-(3-Amino-phenyl)-2-pyrroli...)
Affinity DataKi:  0.310nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463739(CHEMBL4237803)
Affinity DataKi:  0.340nMAssay Description:Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50128074(CHEMBL269483 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg...)
Affinity DataKi:  0.350nMAssay Description:In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  0.360nMAssay Description:Human Opioid receptor kappa 1 mediated stimulation of [35S]- GTPgammaS binding in CHO cells (Agonist potency).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160840(CHEMBL365486 | N-[(S)-1-(3-Methanesulfonylamino-ph...)
Affinity DataKi:  0.360nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NOR-BNI (HCI)2 | NORBNI)
Affinity DataKi:  0.370nMAssay Description:In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463763(CHEMBL4248374)
Affinity DataKi:  0.390nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Universitaire Vaudois

Curated by ChEMBL
LigandPNGBDBM50156173((1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to AT2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50093968(CHEMBL87207 | N-Methyl-2-(2-nitro-phenyl)-N-((S)-1...)
Affinity DataKi:  0.410nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160832(CHEMBL181279 | N-[1-(3-Hydroxy-phenyl)-2-pyrrolidi...)
Affinity DataKi:  0.440nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50128078(CHEMBL2369408 | Tyr-Gly-Pro-Phe-Leu-Arg-Arg-Arg-Ar...)
Affinity DataKi:  0.440nMAssay Description:In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  0.480nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160842(CHEMBL362248 | N-[(S)-1-(3-aminosulfonylamino-phen...)
Affinity DataKi:  0.480nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50377008(CHEMBL254959)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463751(CHEMBL4244350)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463757(CHEMBL4249385)
Affinity DataKi:  0.510nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

Curated by ChEMBL
LigandPNGBDBM50160836(CHEMBL180803 | N-[1-(3-Methoxy-phenyl)-2-pyrrolidi...)
Affinity DataKi:  0.530nMAssay Description:Displacement of bound [3H]-diprenorphine from membranes expressing cloned human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataKi:  0.540nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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