Affinity DataKi: 0.420nMAssay Description:Inhibition of porcine pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Pharmacokinetics
Curated by ChEMBL
Pharmacokinetics
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Inhibition of human recombinant HSP90 by scintillation proximity competition binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of human plasma carboxypeptidase NMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Pharmacokinetics
Curated by ChEMBL
Pharmacokinetics
Curated by ChEMBL
Affinity DataKi: 2.10nMAssay Description:Inhibition of human recombinant HSP90 by scintillation proximity competition binding assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Pharmacokinetics
Curated by ChEMBL
Pharmacokinetics
Curated by ChEMBL
Affinity DataKi: 3.30nMAssay Description:Inhibition of human recombinant HSP90 by scintillation proximity competition binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Binding affinity to human N-terminal polyHis-tagged GRP94 (L69 to N337) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence polarizat...More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Binding affinity to human N-terminal polyHis-tagged GRP94 (L69 to N337) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence polarizat...More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 5.01nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Pharmacokinetics
Curated by ChEMBL
Pharmacokinetics
Curated by ChEMBL
Affinity DataKi: 6.60nMAssay Description:Inhibition of human recombinant HSP90 by scintillation proximity competition binding assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Pharmacokinetics
Curated by ChEMBL
Pharmacokinetics
Curated by ChEMBL
Affinity DataKi: 7.30nMAssay Description:Inhibition of human recombinant HSP90 by scintillation proximity competition binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 7.90nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 7.90nMAssay Description:Displacement of [125I]CXCL12 from human CXCR7 expressed in CHO-K1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 7.94nMAssay Description:Displacement of [125I]CXCL12 from human CXCR7 expressed in CHO-K1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Pharmacokinetics
Curated by ChEMBL
Pharmacokinetics
Curated by ChEMBL
Affinity DataKi: 9.70nMAssay Description:Inhibition of human recombinant HSP90 by scintillation proximity competition binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of human TAFIaMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of bovine pancreatic carboxypeptidase AMore data for this Ligand-Target Pair
Affinity DataKi: 12.6nMAssay Description:Displacement of [125I]CXCL12 from human CXCR7 expressed in CHO-K1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 12.6nMAssay Description:Displacement of [125I]CXCL12 from human CXCR7 expressed in CHO-K1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Displacement of [125I]CXCL12 from human CXCR7 expressed in CHO-K1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Displacement of [125I]CXCL12 from human CXCR7 expressed in CHO-K1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Displacement of [125I]CXCL12 from human CXCR7 expressed in CHO-K1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Displacement of [125I]CXCL12 from human CXCR7 expressed in CHO-K1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: <13nMAssay Description:Inhibition of human ERG by membrane-competitive-binding assayMore data for this Ligand-Target Pair
TargetHeat shock protein 75 kDa, mitochondrial(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Binding affinity to human recombinant TRAP1 after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Displacement of [125I]CXCL12 from mouse CXCR7 expressed in CHO-K1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Modulation of ProLink-fused human CXCR7 expressed in CHOK1 cell membranes assessed as induction of EA-tagged beta-arrestin recruitment after 30 mins ...More data for this Ligand-Target Pair
Affinity DataKi: 29nMAssay Description:Displacement of [125I]CXCL12 from human CXCR7 expressed in CHO-K1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Displacement of [125I]CXCL12 from human CXCR7 expressed in CHO-K1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 34nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 34nMAssay Description:Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair