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Found 152 with Last Name = 'belardinelli' and Initial = 'l'
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058235(8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipro...)
Affinity DataKi:  0.450nMAssay Description:Inhibition of binding to membranes from HEK293 cells expressing human Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058235(8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipro...)
Affinity DataKi:  0.670nMAssay Description:Binding affinity for Adenosine A1 receptor of rat forebrainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  0.720nMAssay Description:Inhibition of binding to membranes from HEK293 cells expressing human Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for Adenosine A1 receptor from Guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058235(8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipro...)
Affinity DataKi:  2.56nMAssay Description:Binding affinity for Adenosine A1 receptor from Guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058235(8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipro...)
Affinity DataKi:  2.56nMAssay Description:Binding affinity for Adenosine A1 receptor from Guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity for Adenosine A1 receptor from Guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  2.93nMAssay Description:Binding affinity for Adenosine A1 receptor from Guinea pig membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  3.77nMAssay Description:Binding affinity for Adenosine A1 receptor of rat forebrainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058235(8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipro...)
Affinity DataKi:  5.12nMAssay Description:Binding affinity for Adenosine A1 receptor of rat forebrainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  12.6nMAssay Description:Binding affinity for Adenosine A1 receptor of rat forebrainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(GUINEA PIG)
Gilead Sciences

US Patent
LigandPNGBDBM377134(Ethyl 1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxy...)
Affinity DataKi:  505nMAssay Description:Compounds of this invention were assayed to determine their affinity for the A2A receptor in a pig striatum membrane prep. Briefly, 0.2 mg of pig str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(GUINEA PIG)
Gilead Sciences

US Patent
LigandPNGBDBM377144((1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethy...)
Affinity DataKi:  505nMAssay Description:Compounds of this invention were assayed to determine their affinity for the A2A receptor in a pig striatum membrane prep. Briefly, 0.2 mg of pig str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(GUINEA PIG)
Gilead Sciences

US Patent
LigandPNGBDBM377143((1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethy...)
Affinity DataKi:  505nMAssay Description:Compounds of this invention were assayed to determine their affinity for the A2A receptor in a pig striatum membrane prep. Briefly, 0.2 mg of pig str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(GUINEA PIG)
Gilead Sciences

US Patent
LigandPNGBDBM377142(1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl...)
Affinity DataKi:  505nMAssay Description:Compounds of this invention were assayed to determine their affinity for the A2A receptor in a pig striatum membrane prep. Briefly, 0.2 mg of pig str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(GUINEA PIG)
Gilead Sciences

US Patent
LigandPNGBDBM377141((1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydrozymethy...)
Affinity DataKi:  505nMAssay Description:Compounds of this invention were assayed to determine their affinity for the A2A receptor in a pig striatum membrane prep. Briefly, 0.2 mg of pig str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(GUINEA PIG)
Gilead Sciences

US Patent
LigandPNGBDBM377140((1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethy...)
Affinity DataKi:  505nMAssay Description:Compounds of this invention were assayed to determine their affinity for the A2A receptor in a pig striatum membrane prep. Briefly, 0.2 mg of pig str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(GUINEA PIG)
Gilead Sciences

US Patent
LigandPNGBDBM377139(1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl...)
Affinity DataKi: >1.00E+3nMAssay Description:Compounds of this invention were assayed to determine their affinity for the A2A receptor in a pig striatum membrane prep. Briefly, 0.2 mg of pig str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(GUINEA PIG)
Gilead Sciences

US Patent
LigandPNGBDBM377135((4S,2R,3R,5R)-2-{6-Amino-2-[4-(4-chlorophenyl)pyra...)
Affinity DataKi:  5.50E+3nMAssay Description:Compounds of this invention were assayed to determine their affinity for the A2A receptor in a pig striatum membrane prep. Briefly, 0.2 mg of pig str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(GUINEA PIG)
Gilead Sciences

US Patent
LigandPNGBDBM50152084(1-[6-Amino-9-(3,4-dihydroxy-5-hydroxymethyl-tetrah...)
Affinity DataKi:  5.50E+3nMAssay Description:Compounds of this invention were assayed to determine their affinity for the A2A receptor in a pig striatum membrane prep. Briefly, 0.2 mg of pig str...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(GUINEA PIG)
Gilead Sciences

US Patent
LigandPNGBDBM377137((4S,2R,3R,5R)-2-{6-Amino2-[4-(4-methylphenyl)pyraz...)
Affinity DataKi:  5.50E+3nMAssay Description:Compounds of this invention were assayed to determine their affinity for the A2A receptor in a pig striatum membrane prep. Briefly, 0.2 mg of pig str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(GUINEA PIG)
Gilead Sciences

US Patent
LigandPNGBDBM377136((4S,2R,3R,5R)-2-{6-Amino-2-[4-(4-metboxyphenyl)pyr...)
Affinity DataKi:  5.50E+3nMAssay Description:Compounds of this invention were assayed to determine their affinity for the A2A receptor in a pig striatum membrane prep. Briefly, 0.2 mg of pig str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50039698(8-(2-Chloro-ethylamino)-1,3-dipropyl-3,7-dihydro-p...)
Affinity DataIC50:  8nMAssay Description:Inhibition of specific binding of [3H]-CPX to the A1 adenosine receptor in DDT1 MF-2 (DDT) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50039695(Bromo-acetic acid 3-(8-cyclopentyl-2,6-dioxo-1-pro...)
Affinity DataIC50:  9nMAssay Description:Inhibition of specific binding of [3H]-CPX to the A1 adenosine receptor in DDT1 MF-2 (DDT) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50039676(4-Fluorosulfonyl-benzoic acid 3-(8-cyclopentyl-2,6...)
Affinity DataIC50:  10nMAssay Description:Inhibition of specific binding of [3H]-CPX to the A1 adenosine receptor in DDT1 MF-2 (DDT) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50039697(Bromo-acetic acid 2-(8-cyclopentyl-2,6-dioxo-1-pro...)
Affinity DataIC50:  11nMAssay Description:Inhibition of specific binding of [3H]-CPX to the A1 adenosine receptor in DDT1 MF-2 (DDT) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50039701(3-Fluorosulfonyl-benzoic acid 3-(8-cyclopentyl-2,6...)
Affinity DataIC50:  20nMAssay Description:Inhibition of specific binding of [3H]-CPX to the A1 adenosine receptor in DDT1 MF-2 (DDT) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50039674(Bromo-acetic acid 3-(2,6-dioxo-1,3-dipropyl-2,3,6,...)
Affinity DataIC50:  20nMAssay Description:Inhibition of specific binding of [3H]-CPX to the A1 adenosine receptor in DDT1 MF-2 (DDT) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173375(CHEMBL3810248)
Affinity DataIC50:  59nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50039683(4-Fluorosulfonyl-benzoic acid 3-(2,6-dioxo-1,3-dip...)
Affinity DataIC50:  60nMAssay Description:Inhibition of specific binding of [3H]-CPX to the A1 adenosine receptor in DDT1 MF-2 (DDT) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50039696(3-Fluorosulfonyl-benzoic acid 3-(2,6-dioxo-1,3-dip...)
Affinity DataIC50:  80nMAssay Description:Inhibition of specific binding of [3H]-CPX to the A1 adenosine receptor in DDT1 MF-2 (DDT) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50039681(4-Fluorosulfonyl-benzoic acid 3-(8-cyclopentyl-2,6...)
Affinity DataIC50:  87nMAssay Description:Inhibition of specific binding of [3H]-CPX to the A1 adenosine receptor in DDT1 MF-2 (DDT) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cv Therapeutics

Curated by ChEMBL
LigandPNGBDBM50039702(8-[Bis-(2-chloro-ethyl)-amino]-1,3-dipropyl-3,7-di...)
Affinity DataIC50:  90nMAssay Description:Inhibition of specific binding of [3H]-CPX to the A1 adenosine receptor in DDT1 MF-2 (DDT) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  100nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at -80 mV resting membrane potential by electrophy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: <100nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at 3 Hz frequency by manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173495(CHEMBL3809404)
Affinity DataIC50:  102nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173487(CHEMBL3809360)
Affinity DataIC50:  123nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173488(CHEMBL3810234)
Affinity DataIC50:  166nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173372(CHEMBL3808867)
Affinity DataIC50:  182nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173336(CHEMBL3808645)
Affinity DataIC50:  211nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173494(CHEMBL3810347 | US11629146, Compound 108)
Affinity DataIC50:  223nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173134(CHEMBL3809595)
Affinity DataIC50:  250nMAssay Description:Inhibition of Nav1.5 (unknown origin) assessed as inhibition of late sodium current by manual patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50:  260nMAssay Description:Inhibition of NaV1.5 expressed in human HEK293 cells assessed as inhibition of late sodium current at 1 Hz frequency by manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173339(CHEMBL3809838)
Affinity DataIC50:  281nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173134(CHEMBL3809595)
Affinity DataIC50:  333nMAssay Description:Inhibition of 0.1 Hz stimulated human Nav1.5alpha expressed in HEK293 cells assessed as inhibition of late sodium current with 3 compound additions f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173134(CHEMBL3809595)
Affinity DataIC50:  333nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173492(CHEMBL3809528)
Affinity DataIC50:  351nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173496(CHEMBL3809853)
Affinity DataIC50:  353nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173407(CHEMBL3809777)
Affinity DataIC50:  397nMAssay Description:Inhibition of Nav 1.5 (unknown origin) assessed as reduction in late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50173134(CHEMBL3809595)
Affinity DataIC50:  400nMAssay Description:Inhibition of 1 Hz stimulated Nav1.2 (unknown origin) by manual patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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