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Found 61 with Last Name = 'bokesch' and Initial = 'hr'
LigandPNGBDBM32628(FTC | Fumitremorgin C)
Affinity DataIC50:  790nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32630(NSC19139)
Affinity DataIC50:  2.60E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32637(NSC375985)
Affinity DataIC50:  3.70E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM32633(NSC168201)
Affinity DataIC50:  3.90E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32632(NSC120688)
Affinity DataIC50:  4.30E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32629(NSC11668 | cid_223753)
Affinity DataIC50:  4.50E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32636(NSC320852)
Affinity DataIC50:  4.60E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM32635(NSC306698)
Affinity DataIC50:  5.40E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32634(NSC303769)
Affinity DataIC50:  5.80E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50321556(8-hydroxy-5,10-dimethoxy-2-propyl-4H-benzo[h]chrom...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase CBL-B(Homo sapiens)
Yangzhou University

Curated by ChEMBL
LigandPNGBDBM50581864(CHEMBL5076820)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of Cbl-b (unknown origin) assessed as inhibition of Cbl-b dependent auto-ubiquitination in presence of ATP measured after 13 hrs by fluore...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase CBL-B(Homo sapiens)
Yangzhou University

Curated by ChEMBL
LigandPNGBDBM50581863(CHEMBL5093634)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of Cbl-b (unknown origin) assessed as inhibition of Cbl-b dependent auto-ubiquitination in presence of ATP measured after 13 hrs by fluore...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase CBL-B(Homo sapiens)
Yangzhou University

Curated by ChEMBL
LigandPNGBDBM50581858(CHEMBL5087523)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of Cbl-b (unknown origin) assessed as inhibition of Cbl-b dependent auto-ubiquitination in presence of ATP measured after 13 hrs by fluore...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase CBL-B(Homo sapiens)
Yangzhou University

Curated by ChEMBL
LigandPNGBDBM50581859(CHEMBL5083569)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of Cbl-b (unknown origin) assessed as inhibition of Cbl-b dependent auto-ubiquitination in presence of ATP measured after 13 hrs by fluore...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase CBL-B(Homo sapiens)
Yangzhou University

Curated by ChEMBL
LigandPNGBDBM50581862(CHEMBL5092374)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of Cbl-b (unknown origin) assessed as inhibition of Cbl-b dependent auto-ubiquitination in presence of ATP measured after 13 hrs by fluore...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase CBL-B(Homo sapiens)
Yangzhou University

Curated by ChEMBL
LigandPNGBDBM50581861(CHEMBL5089524)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of Cbl-b (unknown origin) assessed as inhibition of Cbl-b dependent auto-ubiquitination in presence of ATP measured after 13 hrs by fluore...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase CBL-B(Homo sapiens)
Yangzhou University

Curated by ChEMBL
LigandPNGBDBM50581860(CHEMBL5078551)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of Cbl-b (unknown origin) assessed as inhibition of Cbl-b dependent auto-ubiquitination in presence of ATP measured after 13 hrs by fluore...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM32624(Botryllamide G, 7 | US8470888, Botryllamide G)
Affinity DataIC50:  6.90E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32624(Botryllamide G, 7 | US8470888, Botryllamide G)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50221718(CHEMBL400538 | comaparvin)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32631(Digitonin | NSC23471)
Affinity DataIC50:  9.70E+3nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32619(Botryllamide B, 2)
Affinity DataIC50:  1.12E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32617(Botryllamide A, 1 | US8470888, Botryllamide A)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32638(Dihydroergocristine | NSC409663)
Affinity DataIC50:  1.18E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall ubiquitin-related modifier 1(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50366295(CHEMBL4163902)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SUMO1 expressed in Escherichia coli assessed as reduction in FL-AR peptide sumoylation measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50321557(5,8-dihydroxy-6,10-dimethoxy-2-methyl-4H-benzo[h]c...)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50242177(5,8-dihydroxy-10-methoxy-2-methyl-4H-benzo[h]chrom...)
Affinity DataIC50:  1.28E+4nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPAX33/FOXO11(Homo sapiens (Human))
Yangzhou University

Curated by ChEMBL
LigandPNGBDBM50595105(CHEMBL5192045)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of PAX3-FOXO1 driven transcriptional activity in human Rh4 cells transfected with ALK-Luc construct incubated for 24 hrs by luciferase ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM32620(Botryllamide C, 3 | US8470888, Botryllamide D)
Affinity DataIC50:  1.64E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32621(Botryllamide D, 4)
Affinity DataIC50:  1.64E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50321555(6-methoxycomaparvin 5-methyl ether | CHEMBL256967)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32623(Botryllamide F, 6 | US8470888, Botryllamide F)
Affinity DataIC50:  1.67E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32623(Botryllamide F, 6 | US8470888, Botryllamide F)
Affinity DataIC50:  1.67E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPaired box protein Pax-3(Homo sapiens)
Yangzhou University

Curated by ChEMBL
LigandPNGBDBM50595107(CHEMBL5185415)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of PAX3-FOXO1 driven transcriptional activity in human Rh4 cells transfected with ALK-Luc construct incubated for 24 hrs by luciferase ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50321558(6-methoxycomaparvin | CHEMBL401565)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of ABCG2-mediated drug efflux expressed in human NCI-H460 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32622(Botryllamide E, 5 | US8470888, Botryllamide I)
Affinity DataIC50:  2.33E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32622(Botryllamide E, 5 | US8470888, Botryllamide I)
Affinity DataIC50:  2.33E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPaired box protein Pax-3(Homo sapiens)
Yangzhou University

Curated by ChEMBL
LigandPNGBDBM50595109(CHEMBL5185993)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of PAX3-FOXO1 driven transcriptional activity in human Rh4 cells transfected with ALK-Luc construct incubated for 24 hrs by luciferase ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM32625(Botryllamide H, 8 | Botryllamide J, 10)
Affinity DataIC50:  2.69E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM97639(US8470888, Botryllamide J)
Affinity DataIC50:  2.69E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32617(Botryllamide A, 1 | US8470888, Botryllamide A)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM32617(Botryllamide A, 1 | US8470888, Botryllamide A)
Affinity DataIC50:  3.34E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32626(Botryllamide I, 9)
Affinity DataIC50:  4.14E+4nMpH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32622(Botryllamide E, 5 | US8470888, Botryllamide I)
Affinity DataIC50:  4.14E+4nMAssay Description:Inhibition assay using ABCG2 or BCRP1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPaired box protein Pax-3(Homo sapiens)
Yangzhou University

Curated by ChEMBL
LigandPNGBDBM50595106(CHEMBL5180582)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of PAX3-FOXO1 driven transcriptional activity in human Rh4 cells transfected with ALK-Luc construct incubated for 24 hrs by luciferase ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPaired box protein Pax-3(Homo sapiens)
Yangzhou University

Curated by ChEMBL
LigandPNGBDBM50595108(CHEMBL5175239)
Affinity DataIC50:  6.70E+4nMAssay Description:Inhibition of PAX3-FOXO1 driven transcriptional activity in human Rh4 cells transfected with ALK-Luc construct incubated for 24 hrs by luciferase ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSmall ubiquitin-related modifier 1(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50366293(CHEMBL4166477)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SUMO1 expressed in Escherichia coli assessed as reduction in FL-AR peptide sumoylation measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50398329(CHEMBL2177347)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32625(Botryllamide H, 8 | Botryllamide J, 10)
Affinity DatapH: 7.4 T: 2°CAssay Description:IC50 and maximal activities for inhibition of PhA accumulation were determined from dose-response curves. The accumulation of PhA, a fluorescent ABCG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial PAS domain-containing protein 1(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50398328(CHEMBL2177348)
Affinity DataEC50:  2.70E+3nMAssay Description:Inhibition of HIF2alpha in human 786-0 cells expresseing truncated HIF1alpha assessed as reduction in luciferase activity after 24 hrs by reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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