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Found 167 with Last Name = 'brownell' and Initial = 'al'
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to mGLUR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to mGLUR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataKi:  59nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataKi:  59nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50584759(CHEMBL5089623)
Affinity DataKi:  63nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50584759(CHEMBL5089623)
Affinity DataKi:  63nMAssay Description:Binding affinity to human recombinant mGlur2 assessed as inhibition constant by cAMP Glosensor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50046734(3-(3,4-Dichloro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of [3H]3-beta-(4-fluorophenyl)tropane-2beta-carboxylic acid methyl ester binding to dopamine transporter of cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50035730(3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of [3H]3-beta-(4-fluorophenyl)tropane-2beta-carboxylic acid methyl ester binding to dopamine transporter of cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50010195((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of [3H]3-beta-(4-fluorophenyl)tropane-2beta-carboxylic acid methyl ester binding to dopamine transporter of cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50035738((R)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of [3H]3-beta-(4-fluorophenyl)tropane-2beta-carboxylic acid methyl ester binding to dopamine transporter of cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50046734(3-(3,4-Dichloro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50:  1.40nMAssay Description:Ability to inhibit [3H]citalopram binding to serotonin transporter in cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50046732((R)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of [3H]3-beta-(4-fluorophenyl)tropane-2beta-carboxylic acid methyl ester binding to dopamine transporter of cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50046732((R)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]octane...)
Affinity DataIC50:  1.60nMAssay Description:Ability to inhibit [3H]citalopram binding to serotonin transporter in cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50010195((3S,5R)-methyl 3-(4-iodophenyl)-8-methyl-8-aza-bic...)
Affinity DataIC50:  2.5nMAssay Description:Ability to inhibit [3H]citalopram binding to serotonin transporter in cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50035730(3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2...)
Affinity DataIC50:  2.5nMAssay Description:Ability to inhibit [3H]citalopram binding to serotonin transporter in cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116512(CHEMBL3609741)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116512(CHEMBL3609741)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116512(CHEMBL3609741)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116512(CHEMBL3609741)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116513(CHEMBL3609743)
Affinity DataIC50:  3.70nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116513(CHEMBL3609743)
Affinity DataIC50:  3.70nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50031313(CHEMBL3357575)
Affinity DataIC50:  4.20nMAssay Description:Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50031313(CHEMBL3357575)
Affinity DataIC50:  4.20nMAssay Description:Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...)
Affinity DataIC50:  4.60nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...)
Affinity DataIC50:  4.60nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116520(CHEMBL1300476)
Affinity DataIC50:  4.90nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116520(CHEMBL1300476)
Affinity DataIC50:  4.90nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50031312(CHEMBL3357574)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293721(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50031312(CHEMBL3357574)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116509(CHEMBL3609738)
Affinity DataIC50:  5.20nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116509(CHEMBL3609738)
Affinity DataIC50:  5.30nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50035738((R)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2...)
Affinity DataIC50:  5.90nMAssay Description:Ability to inhibit [3H]citalopram binding to serotonin transporter in cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM403460(US10335399, Example 2-5 | US10806724, Example 2-5)
Affinity DataIC50:  6nMAssay Description:Negative allosteric modulation activity at human recombinant mGlur2 expressed in CHO cells in presence of cAMP by chemiluminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116472(CHEMBL3609734)
Affinity DataIC50:  6.60nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116472(CHEMBL3609734)
Affinity DataIC50:  6.70nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116461(CHEMBL3608323)
Affinity DataIC50:  7.30nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116461(CHEMBL3608323)
Affinity DataIC50:  7.40nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116508(CHEMBL3609737)
Affinity DataIC50:  7.40nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116508(CHEMBL3609737)
Affinity DataIC50:  7.40nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50046733(3-(4-Fluoro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of [3H]3-beta-(4-fluorophenyl)tropane-2beta-carboxylic acid methyl ester binding to dopamine transporter of cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM393885(US10597367, Example 182 | US9969726, Example 182)
Affinity DataIC50:  8.30nMAssay Description:Negative allosteric modulator activity at human recombinant mGlur2 expressed in HEK293 cells by calcium assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...)
Affinity DataIC50:  9.90nMAssay Description:Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116489(CHEMBL3609736)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50116489(CHEMBL3609736)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50046736((R)-3-(3-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1...)
Affinity DataIC50:  10nMAssay Description:Ability to inhibit [3H]citalopram binding to serotonin transporter in cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50293720(CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50451132(CHEMBL2079586 | WIN-35428)
Affinity DataIC50:  11nMAssay Description:Inhibition of [3H]3-beta-(4-fluorophenyl)tropane-2beta-carboxylic acid methyl ester binding to dopamine transporter of cynomolgus monkey striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50031313(CHEMBL3357575)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]-N-(4-{[(2- Chlorophenyl)amino]sulfonyl} phenyl )pyridine-2-carboxamide from human mGlu4 receptor after 30 mins by scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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