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Found 254 with Last Name = 'butkiewicz' and Initial = 'n'
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50187938(3-{(7R,9S,12S)-9-[1-((S)-dimethylcarbamoyl-phenyl-...)
Affinity DataKi:  6nMAssay Description:Binding affinity to HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12493((2S)-({N-[3-({[(7R,9S,12S)-12-cyclohexyl-5,5-dimet...)
Affinity DataKi:  6nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12483((2S)-({N-[3-({[(5S,8S,10R)-5-cyclohexyl-3,6-dioxo-...)
Affinity DataKi:  7nM ΔG°:  -47.3kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50187936((7R,9S,12S)-12-cyclohexyl-11,14-dioxo-2,6-dioxa-10...)
Affinity DataKi:  8nMAssay Description:Binding affinity to HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12476((2S)-({N-[(3S)-3-({[(7R,9S,12S)-12-cyclohexyl-11,1...)
Affinity DataKi:  8nM ΔG°:  -47.0kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12287(SCH 491762 | tert-butyl N-[(1S)-2-[(1R,2S,5S)-2-[(...)
Affinity DataKi:  8nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12475((2S)-({N-[3-({[(7R,9S,12S)-12-cyclohexyl-11,14-dio...)
Affinity DataKi:  10nM ΔG°:  -46.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12484((2S)-({N-[3-({[(7R,9S,12S)-12-cyclohexyl-11,14-dio...)
Affinity DataKi:  10nM ΔG°:  -46.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9761(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)
Affinity DataKi:  10nM ΔG°:  -46.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50187934((7R,9S,12S)-12-cyclohexyl-19-methyl-11,14-dioxo-2,...)
Affinity DataKi:  12nMAssay Description:Binding affinity to HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12309((1R,5S)-N-[3-amino-1-(cyclopropylmethyl)-2,3-dioxo...)
Affinity DataKi:  13nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9763(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)
Affinity DataKi:  13nM ΔG°:  -45.8kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12311((1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataKi:  14nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9699((2S)-2-[2-(3-{[(3S,18S)-3-cyclohexyl-2,5-dioxo-12-...)
Affinity DataKi:  15nM ΔG°:  -45.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12480((2S)-({N-[(3S)-3-({[(7R,9S,12S)-12-tert-butyl-11,1...)
Affinity DataKi:  15nM ΔG°:  -45.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12492(Proline-Based Macrocycle 44 | tert-butyl (2S)-({N-...)
Affinity DataKi:  16nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12307((1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataKi:  16nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12494((2S)-({N-[3-({[(7R,9S,12S)-12-tert-butyl-5,5-dimet...)
Affinity DataKi:  17nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9753(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)
Affinity DataKi:  19nM ΔG°:  -44.8kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50187930(4-{(7R,9S,12S)-9-[1-((S)-dimethylcarbamoyl-phenyl-...)
Affinity DataKi:  19nMAssay Description:Binding affinity to HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12495((2S)-({N-[3-({[(7R,9S,12S)-12-isopropyl-5,5-dimeth...)
Affinity DataKi:  19nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9760(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)
Affinity DataKi:  19nM ΔG°:  -44.8kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9758(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)
Affinity DataKi:  20nM ΔG°:  -44.7kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9762(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)
Affinity DataKi:  21nM ΔG°:  -44.6kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9700(3-{[(3S,18S)-3-cyclohexyl-2,5-dioxo-12-oxa-1,4-dia...)
Affinity DataKi:  21nM ΔG°:  -44.6kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12286(1,1-Dimethylethyl-[1(S)-cyclohexyl-2-[(1R,5S)-2(S)...)
Affinity DataKi:  25nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50187935((6R,8S,11S)-11-cyclohexyl-10,13-dioxo-2,5-dioxa-9,...)
Affinity DataKi:  25nMAssay Description:Binding affinity to HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50187929((7R,9S,12S)-12-cyclohexyl-15-methyl-11,14-dioxo-2,...)
Affinity DataKi:  26nMAssay Description:Binding affinity to HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9754(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)
Affinity DataKi:  27nM ΔG°:  -43.9kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50187927((7R,9S,12S)-12-cyclohexyl-18-methyl-11,14-dioxo-2,...)
Affinity DataKi:  30nMAssay Description:Binding affinity to HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50024579(CHEMBL3084341)
Affinity DataKi:  30nMAssay Description:Binding affinity to HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12482(3-{[(6R,8S,11S)-11-cyclohexyl-10,13-dioxo-2,5-diox...)
Affinity DataKi:  30nM ΔG°:  -43.7kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50187937((7R,9S,12S)-12-cyclohexyl-18-methoxy-11,14-dioxo-2...)
Affinity DataKi:  32nMAssay Description:Binding affinity to HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12308((1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataKi:  35nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12486((2S)-({N-[3-({[(7R,9S,12S)-12-cyclohexyl-11,14-dio...)
Affinity DataKi:  36nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12305((2R)-3-methylbutan-2-yl N-[(2S)-1-[(1R,2S,5S)-2-[(...)
Affinity DataKi:  36nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12498((2S)-({N-[3-({[(7R,9S,12S)-12-(2,3-dihydro-1H-inde...)
Affinity DataKi:  40nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9752(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)
Affinity DataKi:  40nM ΔG°:  -42.9kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9756(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)
Affinity DataKi:  41nM ΔG°:  -42.9kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12474(Proline-Based Macrocycle 22 | tert-butyl (2S)-({N-...)
Affinity DataKi:  44nM ΔG°:  -42.7kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12497((2S)-({N-[3-({[(7R,9S,12S)-5,5-dimethyl-11,14-diox...)
Affinity DataKi:  46nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12314((1R,5S)-N-[3-amino-1-(cyclopropylmethyl)-2,3-dioxo...)
Affinity DataKi:  50nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12315((1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxop...)
Affinity DataKi:  50nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12292(1,1-Dimethylethyl-[2-[(1R,5S)-2(S)-[[[1-(2-amino-1...)
Affinity DataKi:  50nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9931((2S)-2-(2-{3-[(2S)-2-[(2S)-2-cyclohexyl-2-{[(2-met...)
Affinity DataKi:  50nM ΔG°:  -42.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12274(1-Methyl-1-Phenylethyl-[[3-[[[(1R,5S)-3-[(S)-cyclo...)
Affinity DataKi:  50nM ΔG°:  -42.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9759(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)
Affinity DataKi:  51nM ΔG°:  -42.3kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9757(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)
Affinity DataKi:  53nM ΔG°:  -42.2kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12269(1,1-Dimethylethyl-[1(S)-cyclohexyl-2-[(1R,5S)-6,6-...)
Affinity DataKi:  55nM ΔG°:  -42.1kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12267(1,1-Dimethylethyl-[1(S)-cyclohexyl-2-[(1R,5S)-6,6-...)
Affinity DataKi:  56nM ΔG°:  -42.1kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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