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Found 654 with Last Name = 'butler' and Initial = 'm'
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176407(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2-diflu...)
Affinity DataKi:  0.100nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176411(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2,2-tri...)
Affinity DataKi:  0.100nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176407(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2-diflu...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176411(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2,2-tri...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29061(CHEMBL201602 | pyrazolopyrimidinone-based antagoni...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176403(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2-diflu...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataKi:  1nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176418(8-(2-chlorophenyl)-9-(4-chlorophenyl)-1-(2,2,2-tri...)
Affinity DataKi:  1nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176418(8-(2-chlorophenyl)-9-(4-chlorophenyl)-1-(2,2,2-tri...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM29061(CHEMBL201602 | pyrazolopyrimidinone-based antagoni...)
Affinity DataKi:  1nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176402(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2,2-tri...)
Affinity DataKi:  1nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176416(2-(2-chlorophenyl)-3-(4-chlorophenyl)-5-ethyl-6-(2...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176403(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2-diflu...)
Affinity DataKi:  1nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176402(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2,2-tri...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176415(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(3,3,3-tri...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176413(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-propyl-2H-...)
Affinity DataKi:  2nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176413(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-propyl-2H-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176416(2-(2-chlorophenyl)-3-(4-chlorophenyl)-5-ethyl-6-(2...)
Affinity DataKi:  3nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176410(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2-fluoroe...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176409(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-ethyl-2H-p...)
Affinity DataKi:  4nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176404(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2,2-tri...)
Affinity DataKi:  4nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182669((S)-3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6,8-dif...)
Affinity DataKi:  4nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176412(6-benzyl-2-(2-chlorophenyl)-3-(4-chlorophenyl)-2H-...)
Affinity DataKi:  4nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176409(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-ethyl-2H-p...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176415(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(3,3,3-tri...)
Affinity DataKi:  4nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176410(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2-fluoroe...)
Affinity DataKi:  5nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176412(6-benzyl-2-(2-chlorophenyl)-3-(4-chlorophenyl)-2H-...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176414(2-(2-chlorophenyl)-3-(4-chlorophenyl)-5-isopropyl-...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182665((R)-3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6,8-dif...)
Affinity DataKi:  7nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176404(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2,2-tri...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182666(3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluoro-8-...)
Affinity DataKi:  10nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182662((S)-3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluor...)
Affinity DataKi:  11nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182667(3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6,8-difluor...)
Affinity DataKi:  11nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182674((R)-3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluor...)
Affinity DataKi:  12nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176406(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(piperidin...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176414(2-(2-chlorophenyl)-3-(4-chlorophenyl)-5-isopropyl-...)
Affinity DataKi:  13nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182659(3-{4-[1-(1-tert-butyl-3-carboxy-4-oxo-6-fluoro-7-q...)
Affinity DataKi:  13nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182663(3-{4-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluoro-8-...)
Affinity DataKi:  14nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182673(3-{4-[1-(1-(4-fluorophenyl)-3-carboxy-4-oxo-6-fluo...)
Affinity DataKi:  17nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182672(1-ethyl-7-(4-(4-(4-(3-ethyl-4-methylphenylamino)-2...)
Affinity DataKi:  18nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182676(3-{4-[1-(1-{2,4-difluorophenyl}-3-carboxy-4-oxo-6-...)
Affinity DataKi:  18nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182671(3-{5-[1-(1-cyclopropyl-3-carboxy-4-oxo-6-fluoro-7-...)
Affinity DataKi:  19nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM21688(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Affinity DataKi:  19nM ΔG°:  -44.8kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM21688(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Affinity DataKi:  19nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176417(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-cyclohexyl...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176406(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(piperidin...)
Affinity DataKi:  20nMAssay Description:Functional activity at human CB1 receptor transfected in CHOK1 cells by [35SGTP]gammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50176419(2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-isopropyl-...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]SR141716 from human CB1 receptor transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50176073(3-{4-[Bis-(2-hydroxy-ethyl)-amino]-butyl}-6-(3-eth...)
Affinity DataKi:  21nMAssay Description:Inhibitory concentration against Bacillus subtilis DNA polymerase IIIC using [3H]dTMP 250 pM (30 degree C for 10 min)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50182670(3-{4-[1-(1-ethyl-3-carboxy-4-oxo-6,8-difluoro-7-qu...)
Affinity DataKi:  21nMAssay Description:Binding affinity to Bacillus subtilis DNA polymerase3CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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