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Found 3475 with Last Name = 'campbell' and Initial = 'a'
TargetB2 bradykinin receptor(RAT)
Novartis Institute For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50370083(CHEMBL1907651)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of specific binding of [3H]-BK (1 nM) to rat Bradykinin receptor B2 by 50% in NG108-15 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319772((2'-methylbiphenyl-4-yl)((1S,5R)-1,3,3-trimethyl-6...)
Affinity DataKi:  0.0500nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319776((2,2'-dimethylbiphenyl-4-yl)((1S,5R)-1,3,3-trimeth...)
Affinity DataKi:  0.0600nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319799((4-(1H-indol-3-yl)-3-methoxyphenyl)((1S,5R)-1,3,3-...)
Affinity DataKi:  0.100nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute Of Mit And Harvard

Curated by ChEMBL
LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi: <0.200nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442142(CHEMBL2441275)
Affinity DataKi:  0.200nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50012990(6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinol...)
Affinity DataKi:  0.220nMAssay Description:Dopamine receptor D2 affinity was tested in vitro against corpus striatum from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50012990(6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinol...)
Affinity DataKi:  0.230nMAssay Description:Agonist activity was tested in vitro against Dopamine receptor from rat brain membranes with [3H]ADT-6,7-dihydroxy-2-aminotetralin]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50007423((R)6-Allyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qui...)
Affinity DataKi:  0.240nMAssay Description:Dopamine receptor D2 affinity was tested in vitro against corpus striatum from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442141(CHEMBL2441276)
Affinity DataKi:  0.251nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442143(CHEMBL2441274)
Affinity DataKi:  0.251nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(RAT)
Novartis Institute For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50370077(CHEMBL1907652)
Affinity DataKi:  0.310nMAssay Description:Inhibition of specific binding of [3H]-BK (1 nM) to rat Bradykinin receptor B2 by 50% in NG108-15 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319774((3-chloro-2'-methylbiphenyl-4-yl)((1S,5R)-1,3,3-tr...)
Affinity DataKi:  0.310nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442145(CHEMBL2441271)
Affinity DataKi:  0.316nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM85095(CAS_151171 | CONIVAPTAN | NSC_151171 | YM087)
Affinity DataKi:  0.360nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319788(CHEMBL1084325 | N-(2'-methoxy-4'-((1S,5R)-1,3,3-tr...)
Affinity DataKi:  0.370nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442146(CHEMBL2441270)
Affinity DataKi:  0.398nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50012991(6-Cyclopropylmethyl-5,6,6a,7-tetrahydro-4H-dibenzo...)
Affinity DataKi:  0.430nMAssay Description:Dopamine receptor D2 affinity was tested in vitro against corpus striatum from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM85095(CAS_151171 | CONIVAPTAN | NSC_151171 | YM087)
Affinity DataKi:  0.430nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(RAT)
Novartis Institute For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50113263((S)-1-[4-(4-benzhydrylthiosemicarbazido)-3-nitrobe...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of specific binding of [3H]-BK (1 nM) to rat Bradykinin receptor B2 by 50% in NG108-15 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(RAT)
Novartis Institute For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50409120(CHEMBL2112044 | CHEMBL2112937)
Affinity DataKi:  0.5nMAssay Description:Inhibition of binding of [3H]-BK to rat bradykinin B2 receptor expressed in NG108-15 neuroblastoma-glioma hybrid cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442149(CHEMBL2441267)
Affinity DataKi:  0.501nMAssay Description:Inhibition of Aurora-B (unknown origin) using 5FAM-PKAtide as substrate after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319780((2-chloro-5-methoxy-2'-methylbiphenyl-4-yl)((1S,5R...)
Affinity DataKi:  0.540nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(RAT)
Novartis Institute For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50113263((S)-1-[4-(4-benzhydrylthiosemicarbazido)-3-nitrobe...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of specific binding of [3H]-BK (1 nM) to rat Bradykinin receptor B2 by 50% in NG108-15 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319782((2-methoxy-2',6'-dimethylbiphenyl-4-yl)((1S,5R)-1,...)
Affinity DataKi:  0.600nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(RAT)
Novartis Institute For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50409120(CHEMBL2112044 | CHEMBL2112937)
Affinity DataKi:  0.600nMAssay Description:Inhibition of binding of [3H]-BK to rat bradykinin B2 receptor expressed in NG108-15 neuroblastoma-glioma hybrid cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442139(CHEMBL2441273)
Affinity DataKi:  0.631nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319806((3-methoxy-4-(quinolin-8-yl)phenyl)((1S,5R)-1,3,3-...)
Affinity DataKi:  0.710nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319797((4-(benzo[b]thiophen-3-yl)-3-methoxyphenyl)((1S,5R...)
Affinity DataKi:  0.790nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Novartis Institute For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50409527(CHEMBL2112283)
Affinity DataKi:  0.790nMAssay Description:Displacement of [3H]BK (1 nM) from human Bradykinin receptor B2 expressed in Cos-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319792((2-methoxy-4'-methylbiphenyl-4-yl)((1S,5R)-1,3,3-t...)
Affinity DataKi:  0.800nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50012994(6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quino...)
Affinity DataKi:  0.800nMAssay Description:Dopamine receptor D2 affinity was tested in vitro against corpus striatum from rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442147(CHEMBL2441269)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319787(2'-methoxy-N-methyl-4'-((1S,5R)-1,3,3-trimethyl-6-...)
Affinity DataKi:  1.03nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319803((4-(2-chloro-1,2-pyridin-3-yl)-3-methoxyphenyl)((1...)
Affinity DataKi:  1.07nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50023737(6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quino...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity against dopamine agonist sites from rat brain corpus striatal preparations using [3H]ADTNMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM50041628((2S,3S,5R)-8-(3-Fluoro-propyl)-3-(4-iodo-phenyl)-8...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity for dopamine transporters in rat brain tissue.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM50041625((2S,5R)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity for dopamine transporters in rat brain tissue.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Novartis Institute For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50409529(CHEMBL2112221)
Affinity DataKi:  1.47nMAssay Description:Displacement of [3H]BK (1 nM) from human Bradykinin receptor B2 expressed in Cos-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50012994(6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quino...)
Affinity DataKi:  1.5nMAssay Description:Agonist activity was tested in vitro against Dopamine receptor from rat brain membranes with [3H]ADT-6,7-dihydroxy-2-aminotetralin]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute Of Mit And Harvard

Curated by ChEMBL
LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi:  1.5nMAssay Description:Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442140(CHEMBL2441277)
Affinity DataKi:  1.60nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(RAT)
Novartis Institute For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50085685(4-benzhydrylamino(thioxo)methylhydrazine-3-nitrobe...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of binding of [3H]-BK to rat bradykinin B2 receptor expressed in NG108-15 neuroblastoma-glioma hybrid cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50442149(CHEMBL2441267)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319791((4'-chloro-2-methoxy-2'-methylbiphenyl-4-yl)((1S,5...)
Affinity DataKi:  2.26nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50023737(6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quino...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity against Dopamine receptor D2 from rat brain corpus striatal preparations using [3H]-SpiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319784((2''-Methoxy-[1,1',2',1'']terphenyl-4''-yl)-((1S,5...)
Affinity DataKi:  2.60nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM84636(CHEMBL27559 | NPA-11-OH-R,(+))
Affinity DataKi:  2.70nMAssay Description:Binding affinity against Dopamine receptor D2 from rat brain corpus striatal preparations using [3H]-SpiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319785((5'-chloro-2-methoxy-2'-methylbiphenyl-4-yl)((1S,5...)
Affinity DataKi:  2.75nMAssay Description:Displacement [3H]Arg human recombinant Vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Novartis Institute For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50409528(CHEMBL2112220)
Affinity DataKi:  2.79nMAssay Description:Displacement of [3H]BK (1 nM) from human Bradykinin receptor B2 expressed in Cos-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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