Affinity DataIC50: 2nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of MINK (unknown origin) in presence of ATP (Km)More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of TNIK (unknown origin) in presence of ATP (Km)More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 96nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human MAP4K4 transfected in 293 MSR cells assessed as inhibition of phosphorylation of traf2 at ser/thr residue by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 248nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat double mutant (Gln50Lys Gln55His) enzyme using malachite...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of human MAP4K4 transfected in 293 MSR cells assessed as inhibition of phosphorylation of traf2 at ser/thr residue by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 470nMAssay Description:Inhibition of human MAP4K4 transfected in 293 MSR cells assessed as inhibition of phosphorylation of traf2 at ser/thr residue by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat double mutant (Gln50Lys Gln55His) enzyme using malachite...More data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of human MAP4K4 transfected in 293 MSR cells assessed as inhibition of phosphorylation of traf2 at ser/thr residue by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of human MAP4K4 transfected in 293 MSR cells assessed as inhibition of phosphorylation of traf2 at ser/thr residue by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 720nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 770nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
Affinity DataIC50: 790nMAssay Description:Concentration required for 50% Inhibition against (F16BP) Fructose-1,6-bisphosphatase in rat double mutant (Gln50Lys Gln55His) enzyme using malachite...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 861nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity of the compound against Fructose-1,6-bisphosphatase (F16BPase) in porcine kidneyMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of (EGFR) epidermal growth factor receptor tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 1.72E+3nMAssay Description:Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km) by FRET assayMore data for this Ligand-Target Pair