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Found 43 with Last Name = 'castro-palomino laria' and Initial = 'jc'
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128311(US8796284, 93)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128297(US8796284, 4)
Affinity DataKi:  6nM ΔG°:  -46.9kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128310(US8796284, 48)
Affinity DataKi:  7nM ΔG°:  -46.5kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128307(US8796284, 38)
Affinity DataKi:  7nM ΔG°:  -46.5kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128306(US8796284, 36)
Affinity DataKi:  8nM ΔG°:  -46.2kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128305(US8796284, 29)
Affinity DataKi:  10nM ΔG°:  -45.7kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128296(US8796284, 3)
Affinity DataKi:  11nM ΔG°:  -45.4kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128295(US8796284, 1)
Affinity DataKi:  12nM ΔG°:  -45.2kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375232(3-chloro-5-(3-fluoropyridin-4-yl)-6-(pyridin-4-yl)...)
Affinity DataKi:  12nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128311(US8796284, 93)
Affinity DataKi:  12nM ΔG°:  -47.0kJ/moleT: 2°CAssay Description:hese assays were performed at adenosine receptors transfected using a cAMP enzymeimmunoassay kit (Amersham Biosciences). CHO-A2A cells were seeded (1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375233(3-bromo-5-(3-fluoropyridin-4-yl)-6-(pyridin-4-yl)p...)
Affinity DataKi:  13nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128298(US8796284, 5)
Affinity DataKi:  14nM ΔG°:  -44.8kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128308(US8796284, 44)
Affinity DataKi:  14nM ΔG°:  -44.8kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128303(US8796284, 20)
Affinity DataKi:  14nM ΔG°:  -44.8kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128304(US8796284, 24)
Affinity DataKi:  16nM ΔG°:  -44.5kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128309(US8796284, 46)
Affinity DataKi:  17nM ΔG°:  -44.3kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128299(US8796284, 8)
Affinity DataKi:  18nM ΔG°:  -44.2kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128301(US8796284, 10)
Affinity DataKi:  21nM ΔG°:  -43.8kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375229(3-chloro-5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)...)
Affinity DataKi:  23.9nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375234(3-chloro-5-(3-fluoropyridin-4-yl)-6-(6-methoxypyri...)
Affinity DataKi:  24nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128295(US8796284, 1)
Affinity DataKi:  25nM ΔG°:  -45.1kJ/moleT: 2°CAssay Description:hese assays were performed at adenosine receptors transfected using a cAMP enzymeimmunoassay kit (Amersham Biosciences). CHO-A2A cells were seeded (1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128300(US8796284, 9)
Affinity DataKi:  33nM ΔG°:  -42.7kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375227(3-chloro-6-(pyridin-3-yl)-5-(pyridin-4-yl)pyridin-...)
Affinity DataKi:  34.5nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128302(US8796284, 13)
Affinity DataKi:  35nM ΔG°:  -42.6kJ/moleT: 2°CAssay Description:Competition assays were carried out by incubation of membranes from hA1 receptors transfected to CHO cells, [3H]-DPCPX as radioligand, buffer (HEPES ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375230(3-bromo-5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)p...)
Affinity DataKi:  37nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375228(3-bromo-6-(pyridin-3-yl)-5-(pyridin-4-yl)pyridin-2...)
Affinity DataKi:  46.1nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128302(US8796284, 13)
Affinity DataKi:  50nM ΔG°:  -43.3kJ/moleT: 2°CAssay Description:hese assays were performed at adenosine receptors transfected using a cAMP enzymeimmunoassay kit (Amersham Biosciences). CHO-A2A cells were seeded (1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM128299(US8796284, 8)
Affinity DataKi:  60nM ΔG°:  -42.9kJ/moleT: 2°CAssay Description:hese assays were performed at adenosine receptors transfected using a cAMP enzymeimmunoassay kit (Amersham Biosciences). CHO-A2A cells were seeded (1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375226(5-(3-fluoropyridin-4-yl)-6-(pyridin-4-yl)pyridin-2...)
Affinity DataKi:  149nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375231(3-chloro-6-(5-fluoropyridin-3-yl)-5-(3-fluoropyrid...)
Affinity DataKi:  150nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375228(3-bromo-6-(pyridin-3-yl)-5-(pyridin-4-yl)pyridin-2...)
Affinity DataKi:  300nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375227(3-chloro-6-(pyridin-3-yl)-5-(pyridin-4-yl)pyridin-...)
Affinity DataKi:  500nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375232(3-chloro-5-(3-fluoropyridin-4-yl)-6-(pyridin-4-yl)...)
Affinity DataKi:  555nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375233(3-bromo-5-(3-fluoropyridin-4-yl)-6-(pyridin-4-yl)p...)
Affinity DataKi:  1.30E+3nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375229(3-chloro-5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)...)
Affinity DataKi:  4.80E+3nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375231(3-chloro-6-(5-fluoropyridin-3-yl)-5-(3-fluoropyrid...)
Affinity DataKi: >5.00E+3nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375230(3-bromo-5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)p...)
Affinity DataKi: >5.00E+3nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375226(5-(3-fluoropyridin-4-yl)-6-(pyridin-4-yl)pyridin-2...)
Affinity DataKi: >5.00E+3nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375234(3-chloro-5-(3-fluoropyridin-4-yl)-6-(6-methoxypyri...)
Affinity DataKi: >5.00E+3nMAssay Description:The binding assay for adenosine A2B receptor subtype was carried out on human recombinant source (HEK-293 cells) and [3H]DPCPX as radioligand, accord...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375229(3-chloro-5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)...)
Affinity DataIC50:  98nMAssay Description:The experiment of binding to MT3 sites was carried out on hamster brain membranes using [125I]2-iodomelatonin as radioligand in accordance with the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375227(3-chloro-6-(pyridin-3-yl)-5-(pyridin-4-yl)pyridin-...)
Affinity DataIC50:  130nMAssay Description:The experiment of binding to MT3 sites was carried out on hamster brain membranes using [125I]2-iodomelatonin as radioligand in accordance with the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375228(3-bromo-6-(pyridin-3-yl)-5-(pyridin-4-yl)pyridin-2...)
Affinity DataIC50:  140nMAssay Description:The experiment of binding to MT3 sites was carried out on hamster brain membranes using [125I]2-iodomelatonin as radioligand in accordance with the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
Palobiofarma

US Patent
LigandPNGBDBM375231(3-chloro-6-(5-fluoropyridin-3-yl)-5-(3-fluoropyrid...)
Affinity DataIC50:  250nMAssay Description:The experiment of binding to MT3 sites was carried out on hamster brain membranes using [125I]2-iodomelatonin as radioligand in accordance with the p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent