BindingDB PrimarySearch_ki

Found 574 with Last Name = 'chen' and Initial = 'cp'

Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530623(CHEMBL4521381)

IC50: 0.0430nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530623(CHEMBL4521381)

IC50: 0.0430nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair

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3D Structure (crystal)

High affinity nerve growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)

IC50: 0.0700nMAssay Description:Inhibition of wildtype human TRKA using poly (Glu,Tyr) 4:1 as substrate in presence of [gamma-33P]ATP by hotspot kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)

IC50: 0.0780nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)

IC50: 0.0780nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50519725(CHEMBL4513768)

IC50: 0.100nMAssay Description:Inhibition of wild type FLT3 ITD mutant (unknown origin) expressed in HEK293T cells assessed as decrease in FLT3 ITD phosphorylation at 0.1 to 1000 n...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50519725(CHEMBL4513768)

IC50: 0.100nMAssay Description:Inhibition of wild type FLT3 (unknown origin) expressed in HEK293T cells assessed as decrease in FLT3 phosphorylation at 0.1 to 1000 nM after 1 hr by...More data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50519725(CHEMBL4513768)

IC50: 0.100nMAssay Description:Inhibition of wild type FLT3 D835Y mutant (unknown origin) expressed in HEK293T cells assessed as decrease in FLT3 D835Y phosphorylation at 0.1 to 10...More data for this Ligand-Target Pair

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High affinity nerve growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM374727((7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)

IC50: 0.110nMAssay Description:Inhibition of wildtype human TRKA using poly (Glu,Tyr) 4:1 as substrate in presence of [gamma-33P]ATP by hotspot kinase assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530623(CHEMBL4521381)

IC50: 0.133nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530623(CHEMBL4521381)

IC50: 0.133nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530618(CHEMBL4559807)

IC50: 0.145nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530618(CHEMBL4559807)

IC50: 0.145nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair

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NT-3 growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50579500(CHEMBL4864729)

IC50: 0.210nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530622(CHEMBL4514452)

IC50: 0.214nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530622(CHEMBL4514452)

IC50: 0.214nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)

IC50: 0.218nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)

IC50: 0.218nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair

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Aurora kinase A(Homo sapiens (Human))
Taiwan National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50241089(2-(ethyl(3-(4-(5-(2-(3-fluorophenylamino)-2-oxoeth...)

IC50: 0.370nMAssay Description:Inhibition of recombinant GST-tagged N-terminal truncated human Aurora A (123 to 401 residues) expressed in Sf9 insect cell using tetra-LRRASLG pepti...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)

IC50: 0.421nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)

IC50: 0.421nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530618(CHEMBL4559807)

IC50: 0.636nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530618(CHEMBL4559807)

IC50: 0.636nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)

IC50: 0.950nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)

IC50: 0.950nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530615(CHEMBL4534719)

IC50: 1.20nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530615(CHEMBL4534719)

IC50: 1.20nMAssay Description:Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent ...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530622(CHEMBL4514452)

IC50: 1.5nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair

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Epidermal growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50530622(CHEMBL4514452)

IC50: 1.5nMAssay Description:Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent k...More data for this Ligand-Target Pair

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BDNF/NT-3 growth factors receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50579500(CHEMBL4864729)

IC50: 1.80nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50434621(CHEMBL2386796)

IC50: 2nMAssay Description:Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysisMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
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Aurora kinase A(Homo sapiens (Human))
Taiwan National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50586463(CHEMBL5083023)

IC50: 2nMAssay Description:Inhibition of GST-tagged AURA Ser123 to 401 residues) (unknown origin) expressed in Sf9 insect cells using tetra-LLRASLG peptide as substrate incubat...More data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50519725(CHEMBL4513768)

IC50: 3nMAssay Description:Inhibition of human C-src using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair

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High affinity nerve growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)

IC50: 3nMAssay Description:Inhibition of wildtype human TRKA using poly (Glu,Tyr) 4:1 as substrate in presence of [gamma-33P]ATP by hotspot kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 3nMAssay Description:Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Aurora kinase A(Homo sapiens (Human))
Taiwan National Health Research Institutes

Curated by ChEMBL

PNG

BDBM31837(2,4-Bisanilinopyrimidine, 10 | Aurora Inhibitor, 3...)

IC50: 3.40nMAssay Description:Inhibition of recombinant GST-tagged N-terminal truncated human Aurora A (123 to 401 residues) expressed in Sf9 insect cell using tetra-LRRASLG pepti...More data for this Ligand-Target Pair

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High affinity nerve growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50577766(CHEMBL4856292)

IC50: 3.90nMAssay Description:Inhibition of wildtype human TRKA using poly (Glu,Tyr) 4:1 as substrate in presence of [gamma-33P]ATP by hotspot kinase assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50434614(CHEMBL2386803)

IC50: 4nMAssay Description:Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysisMore data for this Ligand-Target Pair

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High affinity nerve growth factor receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50519725(CHEMBL4513768)

IC50: 4.90nMAssay Description:Inhibition of human TRKA using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma ATP by hotspot kinase assayMore data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM21079(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)

IC50: 5nMAssay Description:Inhibition of recombinant GST-tagged VEGFR2 expressed in Sf9 insect cells after 120 mins by Kinase-Glo assayMore data for this Ligand-Target Pair

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Aurora kinase A(Homo sapiens (Human))
Taiwan National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50579500(CHEMBL4864729)

IC50: 5.60nMAssay Description:Inhibition of GST-tagged AURA Ser123 to 401 residues) (unknown origin) expressed in Sf9 insect cells using tetra-LLRASLG peptide as substrate incubat...More data for this Ligand-Target Pair

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Aurora kinase A(Homo sapiens (Human))
Taiwan National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50586469(CHEMBL5081247)

IC50: 6nMAssay Description:Inhibition of GST-tagged AURA Ser123 to 401 residues) (unknown origin) expressed in Sf9 insect cells using tetra-LLRASLG peptide as substrate incubat...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50349015(CHEMBL1807483)

IC50: 6nMAssay Description:Inhibition of GST-tagged FLT3 expressing wild type kinase domain expressed in Sf9 insect cells after 4 hrs by Kinase-Glo assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50434629(CHEMBL2386788)

IC50: 6nMAssay Description:Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysisMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
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Aurora kinase A(Homo sapiens (Human))
Taiwan National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50586457(CHEMBL5081608)

IC50: 6nMAssay Description:Inhibition of GST-tagged AURA Ser123 to 401 residues) (unknown origin) expressed in Sf9 insect cells using tetra-LLRASLG peptide as substrate incubat...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50096120(CHEMBL3593291)

IC50: 7nMAssay Description:Inhibition of recombinant GST-tagged VEGFR2 kinase domain (V789 to V1356) (unknown origin) expressed in insect Sf9 cells using polyGlu4:Tyr peptide a...More data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50349013(CHEMBL1807478)

IC50: 7nMAssay Description:Inhibition of GST-tagged FLT3 expressing wild type kinase domain expressed in Sf9 insect cells after 4 hrs by Kinase-Glo assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50349004(CHEMBL1807469)

IC50: 7nMAssay Description:Inhibition of GST-tagged FLT3 expressing wild type kinase domain expressed in Sf9 insect cells after 4 hrs by Kinase-Glo assayMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50434623(CHEMBL2386794)

IC50: 8nMAssay Description:Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysisMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

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Aurora kinase A(Homo sapiens (Human))
Taiwan National Health Research Institutes

Curated by ChEMBL

PNG

BDBM50586462(CHEMBL5093039)

IC50: 8nMAssay Description:Inhibition of GST-tagged AURA Ser123 to 401 residues) (unknown origin) expressed in Sf9 insect cells using tetra-LLRASLG peptide as substrate incubat...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Displayed 1 to 50 (of 574 total ) | Next | Last >>

Filter my 574 hits

Targets 14▿
- Epidermal growth factor receptor 153
- Aurora kinase A 121
- Receptor-type tyrosine-protein kinase FLT3 110
- Peroxisome proliferator-activated receptor gamma 52
- Vascular endothelial growth factor receptor 2 40
- Vascular endothelial growth factor receptor 1 24
- Mast/stem cell growth factor receptor Kit 19
- High affinity nerve growth factor receptor 19
- Peroxisome proliferator-activated receptor delta 15
- Peroxisome proliferator-activated receptor alpha 15
- Aurora kinase B 3
- NT-3 growth factor receptor 1
- Proto-oncogene tyrosine-protein kinase Src 1
- BDNF/NT-3 growth factors receptor 1
- ...
Publications 9▿
- J Med Chem 62: 10108-10123 (2019) 128
- Bioorg Med Chem 19: 4173-82 (2011) 101
- J Med Chem 48: 8194-208 (2005) 82
- Bioorg Med Chem 21: 2856-67 (2013) 70
- Eur J Med Chem 100: 151-61 (2015) 55
- Eur J Med Chem 224: (2021) 45
- J Med Chem 62: 11135-11150 (2019) 44
- J Med Chem 53: 7316-26 (2010) 25
- J Med Chem 64: 7312-7330 (2021) 24
Institutions 2▿
- National Health Research Institutes 550
- Taiwan National Health Research Institutes 24
Affinity: 0.043 to 1.0E+6 nM▿
- IC50 518
- EC50 56
- Affinity ≤ nM
Xtal structures: 11
Docked structures: 1
Catalog Cmpds: 24