Compile Data Set for Download or QSAR
maximum 50k data
Found 47 with Last Name = 'cherukury' and Initial = 'm'
TargetBeta-secretase 2(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476688((R)-3-Imino-2,2,5-trimethyl-5-(8- (prop-1-yn-1-yl)...)
Affinity DataIC50:  12nMAssay Description:A BACE2 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected compounds by AnaSpec BACE2 fluorescent as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476692((R)-5-(3-Fluoro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Affinity DataIC50:  16nMAssay Description:A BACE2 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected compounds by AnaSpec BACE2 fluorescent as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476679((S)-6-(8-(3-Hydroxyprop-1-yn-1-yl) dibenzo[b,d]thi...)
Affinity DataIC50:  17nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476666((S)-6-(3-Fluoro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Affinity DataIC50:  21nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476661((S)-6-(3-Chloro-5-(prop-1-yn-1-yl)- 1H-indol-2-yl)...)
Affinity DataIC50:  24nMAssay Description:A BACE2 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected compounds by AnaSpec BACE2 fluorescent as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476692((R)-5-(3-Fluoro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Affinity DataIC50:  25nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476692((R)-5-(3-Fluoro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Affinity DataIC50:  25nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476660((S)-2-Imino-3,6-dimethyl-6-(8-(prop- 1-yn-1-yl)dib...)
Affinity DataIC50:  26nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476660((S)-2-Imino-3,6-dimethyl-6-(8-(prop- 1-yn-1-yl)dib...)
Affinity DataIC50:  26nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476688((R)-3-Imino-2,2,5-trimethyl-5-(8- (prop-1-yn-1-yl)...)
Affinity DataIC50:  39nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476688((R)-3-Imino-2,2,5-trimethyl-5-(8- (prop-1-yn-1-yl)...)
Affinity DataIC50:  39nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476688((R)-3-Imino-2,2,5-trimethyl-5-(8- (prop-1-yn-1-yl)...)
Affinity DataIC50:  39nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476694((S)-6-(3-Chloro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Affinity DataIC50:  44nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476661((S)-6-(3-Chloro-5-(prop-1-yn-1-yl)- 1H-indol-2-yl)...)
Affinity DataIC50:  44nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476673((6S)-2-Imino-3,6-dimethyl-6-(5-oxido-8- (prop-1-yn...)
Affinity DataIC50:  48nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50080153((1-Aminomethyl-cyclohexyl)-acetic acid | 2-(1-(ami...)
Affinity DataIC50:  70nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476682((S)-6-(8-Cyclopropyldibenzo[b,d] thiophen-2-yl)-2-...)
Affinity DataIC50:  78nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476685((S)-2-Imino-3,6-dimethyl-6-(8-(trifluoro- methyl)d...)
Affinity DataIC50:  81nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476670((S)-6-(5,5-Dioxido-8-(prop-1-yn-1-yl) dibenzo[b,d]...)
Affinity DataIC50:  87nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50168499((1-((1H-tetrazol-5-yl)methyl)cycloheptyl)methanami...)
Affinity DataIC50:  100nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212317((1-((1H-tetrazol-5-yl)methyl)cyclohexyl)methanamin...)
Affinity DataIC50:  108nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476687((R)-5,5-Difluoro-4-methyl-4-(8-(prop- 1-yn-1-yl)di...)
Affinity DataIC50:  202nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476678((S)-2-Imino-6-(8-(3-methoxyprop-1- yn-1-yl)dibenzo...)
Affinity DataIC50:  218nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476686((R)-6-Cyclopropyl-2-imino-3-methyl- 6-(8-(prop-1-y...)
Affinity DataIC50: >300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476684((S)-6-(8-(Diethylamino)dibenzo[b,d] thiophen-2-yl)...)
Affinity DataIC50: >300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476683((S)-8-(2-Imino-1,4-dimethyl-6- oxohexahydropyrimid...)
Affinity DataIC50: >300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476680((S)-6-(8-Bromodibenzo[b,d]thiophen- 2-yl)-2-imino-...)
Affinity DataIC50: >300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476677((S)-8-(2-Imino-1,4-dimethyl-6- oxohexahydropyrimid...)
Affinity DataIC50: >300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476676((S)-6-(9,9-Difluoro-6-(prop-1-yn-1-yl)- 9H-fluoren...)
Affinity DataIC50: >300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476675((S)-6-(9,9-Dimethyl-6-(prop-1-yn-1-yl)- 9H-fluoren...)
Affinity DataIC50: >300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476681((S)-2-Imino-3,6-dimethyl-6-(8-propyl- dibenzo[b,d]...)
Affinity DataIC50: >300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476693((R)-3-Imino-1,5-dimethyl-5-(8-(prop- 1-yn-1-yl)dib...)
Affinity DataIC50: >300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476691((S)-2-Imino-3-(2-methoxyethyl)-6- methyl-6-(8-(pro...)
Affinity DataIC50: >300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476690((S)-3-(2,2-Difluoroethyl)-2-imino-6- methyl-6-(8-(...)
Affinity DataIC50: >300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476689((R)-3-Imino-2,5-dimethyl-5-(8-(prop- 1-yn-1-yl)dib...)
Affinity DataIC50: >300nMAssay Description:A BACE1 activity assay kit from AnaSpec (Fremont, Calif.) was used to determine the potency of the selected BACE1 inhibitors by AnaSpec BACE1 fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50168498((S)-2-((1H-tetrazol-5-yl)methyl)-4-methylpentan-1-...)
Affinity DataIC50:  1.59E+3nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168502((1-((1H-tetrazol-5-yl)methyl)cyclooctyl)methanamin...)
Affinity DataIC50:  2.36E+3nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476694((S)-6-(3-Chloro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Affinity DataIC50:  3.90E+3nMAssay Description:Cathepsin D (Cat D) is a major intercellular member of the mammalian aspartic proteinase family and is thought to be in the normal degradation of int...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168499((1-((1H-tetrazol-5-yl)methyl)cycloheptyl)methanami...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of potassium-evoked [3H]norepinephrine release from rat neocortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50080153((1-Aminomethyl-cyclohexyl)-acetic acid | 2-(1-(ami...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of potassium-evoked [3H]norepinephrine release from rat neocortexMore data for this Ligand-Target Pair
LigandPNGBDBM50168503((1-(aminomethyl)cyclohexyl)methanesulfonic acid | ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50370711(CHEMBL553199)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168504((1-((1-methyl-1H-tetrazol-5-yl)methyl)cyclohexyl)m...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168500((1-(aminomethyl)cyclohexyl)methanesulfinic acid | ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476692((R)-5-(3-Fluoro-8-(prop-1-yn-1-yl) dibenzo[b,d]thi...)
Affinity DataIC50:  1.08E+4nMAssay Description:Cathepsin D (Cat D) is a major intercellular member of the mammalian aspartic proteinase family and is thought to be in the normal degradation of int...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476660((S)-2-Imino-3,6-dimethyl-6-(8-(prop- 1-yn-1-yl)dib...)
Affinity DataIC50:  1.23E+4nMAssay Description:Cathepsin D (Cat D) is a major intercellular member of the mammalian aspartic proteinase family and is thought to be in the normal degradation of int...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Allgenesis Biotherapeutics

US Patent
LigandPNGBDBM476688((R)-3-Imino-2,2,5-trimethyl-5-(8- (prop-1-yn-1-yl)...)
Affinity DataIC50:  1.72E+4nMAssay Description:Cathepsin D (Cat D) is a major intercellular member of the mammalian aspartic proteinase family and is thought to be in the normal degradation of int...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent