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Found 824 with Last Name = 'clarke' and Initial = 'w'
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50206243(CHEMBL3918431)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50235306(CHEMBL4084621)
Affinity DataKi:  3.30nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50206243(CHEMBL3918431)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]Tyr54-alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes co-expressing human RIC3 measured after 2 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50206243(CHEMBL3918431)
Affinity DataKi:  4.80nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50054539(CHEMBL3323088)
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H]Nisoxetine from human NET expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50235306(CHEMBL4084621)
Affinity DataKi:  8.10nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in HEK293 cell membranes incubated for 2 hrs and measured by gamma countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386376(CHEMBL2046865)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Rattus norvegicus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50318112((S)-4-(2-(3-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataKi:  28nMAssay Description:Inhibition of rat IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50062912(CHEMBL796 | Methylphenidate | alpha-phenyl-2-piper...)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]WIN 35,428 from human DAT expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50054539(CHEMBL3323088)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]WIN 35,428 from human DAT expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211195(CHEMBL3944506)
Affinity DataKi:  38nMAssay Description:Displacement of [125I]Tyr54-alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes co-expressing human RIC3 measured after 2 hrs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50164613((-)-Spiro[1-azabicyclo(2.2.2)octane-3,5'-oxazolidi...)
Affinity DataKi:  92nMAssay Description:Displacement of [125I]alpha-bungarotoxin from rat hippocampal alpha7 nAChR measured after 2 hrs by TopCount scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50054539(CHEMBL3323088)
Affinity DataKi:  230nMAssay Description:Displacement of [3H]Citolapram from human SERT expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50062912(CHEMBL796 | Methylphenidate | alpha-phenyl-2-piper...)
Affinity DataKi:  340nMAssay Description:Displacement of [3H]Nisoxetine from human NET expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50062912(CHEMBL796 | Methylphenidate | alpha-phenyl-2-piper...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]Citolapram from human SERT expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610453(2-Phenyl-N-(4-(2,2,2-trifluoroethoxy)pyridin-3-yl)...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613245(CHEMBL5266553)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613418(CHEMBL5268185)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610483(2-Cyclopropyl-N-(4-(4,4-difluoropiperidin-1-yl)pyr...)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610462(N-(4-Morpholinopyridin-3-yl)-2-phenylimidazo[1,2-b...)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610461(N-(4-(4,4-Difluoropiperidin-1-yl)pyridin-3-yl)-2-p...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610477(N-(4-Morpholinopyridin-3-yl)-2-(4-(trifluoromethyl...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610458(2-Phenyl-N-(4-(piperidin-1-yl)pyridin-3-yl)imidazo...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613417(CHEMBL5290300)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610469((S)—N-(4-(3-Methylmorpholino)pyridin-3-yl)-2-pheny...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613415(CHEMBL5273872)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613246(CHEMBL5316226)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610463(BDBM610464 | BDBM610465 | N-(4-(2-Methylmorpholino...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610476(2-(2-Methoxyphenyl)-N-(4-(2-methylmorpholino)pyrid...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610454(N-(4-(Methylsulfonyl)pyridin-3-yl)-2-phenylimidazo...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610452(N-(4-Isopropoxypyridin-3-yl)-2-phenylimidazo[1,2-b...)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610482(2-Cyclopropyl-N-(4-(4-fluorophenyl)pyridin-3-yl)im...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613407(CHEMBL5269649)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610478(N-(4-(2-Methylmorpholino)pyridin-3-yl)-2-(4-(trifl...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613413(CHEMBL5265990)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613402(CHEMBL5270885)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610484(2-Cyclopropyl-N-(4-(2-methylmorpholino)pyridin-3-y...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610451(N-(4-Methylpyridin-3-yl)-2-phenylimidazo[1,2-b]pyr...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50613418(CHEMBL5268185)
Affinity DataIC50:  0.870nMAssay Description:Inhibition of GST tagged GSK-3beta (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613414(CHEMBL5280241)
Affinity DataIC50:  0.880nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610468((R)—N-(4-(3-Methylmorpholino)pyridin-3-yl)-2-pheny...)
Affinity DataIC50:  1nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50613402(CHEMBL5270885)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST tagged GSK-3beta (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM170441(US9085531, 2)
Affinity DataIC50: <1nMAssay Description:Displacement of [3H]Nisoxetine from human NET expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613401(CHEMBL5284458)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610456(N-(4-(4-Fluorophenyl)pyridin-3-yl)-2-phenylimidazo...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM610455(2-Phenyl-N-(4-phenylpyridin-3-yl)imidazo[1,2-b]pyr...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613411(CHEMBL5287898)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50613417(CHEMBL5290300)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST tagged GSK-3beta (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613419(CHEMBL5281592)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST tagged GSK-3alpha (unknown origin) incubated for 1 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50054533(CHEMBL3323173)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]Nisoxetine from human NET expressed in HEK293E cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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