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Found 986 with Last Name = 'conde' and Initial = 's'
TargetAcetylcholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322767(2-Methyl-7-{[8-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM31592(PF-2545920 | US9138494, MP-10 | substituted pyraz...)
Affinity DataIC50:  0.646nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322768(5-Chloro-7-{[9-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322767(2-Methyl-7-{[8-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  2nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Instituto De Qui£?Mica Medica-Csic

Curated by ChEMBL
LigandPNGBDBM50347535(CHEMBL1801637)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant GSK3beta using prephosphorylated polypeptide substrate after 30 mins by Glow-type luminescence assay in presence of 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322766(7-{[9-(1,2,3,4-Tetrahydroacridin-9-ylamino)nonylam...)
Affinity DataIC50:  5nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322766(7-{[9-(1,2,3,4-Tetrahydroacridin-9-ylamino)nonylam...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322767(2-Methyl-7-{[8-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of human serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322768(5-Chloro-7-{[9-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322777(2-Methyl-7-{[10-(1,2,3,4-tetrahydroacridin-9-ylami...)
Affinity DataIC50:  7nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:Inhibition of BuChE in horse serum using butyrylthiocholine as substrate by Ellman methodMore data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:Inhibition of equine serum BuChE by Ellman's methodMore data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:Inhibition of horse serum BuChE using butyrylthiocholine as substrate by UV spectroscopic analysisMore data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8960((+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimet...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substrat...More data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:Inhibition of BuChE in horse serum by Ellman methodMore data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322766(7-{[9-(1,2,3,4-Tetrahydroacridin-9-ylamino)nonylam...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322766(7-{[9-(1,2,3,4-Tetrahydroacridin-9-ylamino)nonylam...)
Affinity DataIC50:  20nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322770(7-{[7-(1,2,3,4-Tetrahydroacridin-9-ylamino)heptyla...)
Affinity DataIC50:  25nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322782(5-Chloro-7-{{3-{methyl[3-(1,2,3,4-tetrahydroacridi...)
Affinity DataIC50:  30nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322771(7-{[8-(1,2,3,4-Tetrahydroacridin-9-ylamino)octylam...)
Affinity DataIC50:  30nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  40nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's methodMore data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BuChE in serumMore data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  40nMAssay Description:Inhibition of AChE in bovine erythrocyte by Ellman methodMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  40nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  40nMAssay Description:Inhibition of AChE in bovine erythrocytes using acetylthiocholine as substrate by Ellman methodMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Instituto De Qui£?Mica Medica-Csic

Curated by ChEMBL
LigandPNGBDBM50347531(CHEMBL1801633)
Affinity DataIC50:  47nMAssay Description:Inhibition of human recombinant GSK3beta using prephosphorylated polypeptide substrate after 30 mins by Glow-type luminescence assay in presence of 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50014884(CHEMBL3262038)
Affinity DataIC50:  47nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322772(7-{[10-(1,2,3,4-Tetrahydroacridin-9-ylamino)decyla...)
Affinity DataIC50:  50nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50311996((S)-hexyl 5-(2-(1-benzylpiperidin-4-yl)ethylamino)...)
Affinity DataIC50:  50nMAssay Description:Inhibition of BuChE in horse serum by Ellman methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322774(7-{{3-{Methyl[3-(1,2,3,4-tetrahydroacridin-9-ylami...)
Affinity DataIC50:  50nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50014825(CHEMBL3262031)
Affinity DataIC50:  54nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322768(5-Chloro-7-{[9-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50014905(CHEMBL3262043)
Affinity DataIC50:  60nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322772(7-{[10-(1,2,3,4-Tetrahydroacridin-9-ylamino)decyla...)
Affinity DataIC50:  65nMAssay Description:Inhibition of horse serum BChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50014881(CHEMBL3259842)
Affinity DataIC50:  65nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50014906(CHEMBL3262044)
Affinity DataIC50:  66nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322777(2-Methyl-7-{[10-(1,2,3,4-tetrahydroacridin-9-ylami...)
Affinity DataIC50:  70nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50311996((S)-hexyl 5-(2-(1-benzylpiperidin-4-yl)ethylamino)...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human BuChE in serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322767(2-Methyl-7-{[8-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  75nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322774(7-{{3-{Methyl[3-(1,2,3,4-tetrahydroacridin-9-ylami...)
Affinity DataIC50:  80nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas (Csic)

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  83nMAssay Description:Inhibition of human recombinant PDE4D3 assessed after 60 mins by IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322768(5-Chloro-7-{[9-(1,2,3,4-tetrahydroacridin-9-ylamin...)
Affinity DataIC50:  85nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50014842(CHEMBL3262032)
Affinity DataIC50:  85nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected Sf9 cells using [3H]cAMP as substrate after 60 mins by TopCount scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322771(7-{[8-(1,2,3,4-Tetrahydroacridin-9-ylamino)octylam...)
Affinity DataIC50:  90nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas (Csic)

Curated by ChEMBL
LigandPNGBDBM50277784(CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant PDE7A1 assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Instituto De Quimica Medica

Curated by ChEMBL
LigandPNGBDBM50322782(5-Chloro-7-{{3-{methyl[3-(1,2,3,4-tetrahydroacridi...)
Affinity DataIC50:  90nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's reactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50059991(CHEMBL3394362)
Affinity DataIC50:  98nMAssay Description:Inhibition of rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP substrate incubated for 60 mins by topcount scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas (Csic)

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  98nMAssay Description:Inhibition of human recombinant PDE4B2 assessed after 60 mins by IMAP fluorescence polarization assayMore data for this Ligand-Target Pair
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