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Found 127 with Last Name = 'conrad' and Initial = 'r'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi: <1nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to reninMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to reninMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  3nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281641((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  4nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  5nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281640(CHEMBL433729 | Pyridine-2-carboxylic acid ((1S,2S,...)
Affinity DataKi:  8nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  8nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281651((2S,4S,5S)-5-Acetylamino-6-cyclohexyl-4-hydroxy-2-...)
Affinity DataKi:  8nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  9nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281648(CHEMBL166640 | [(S)-1-((1S,2S,4S)-1-Cyclohexylmeth...)
Affinity DataKi:  10nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  12nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to pepsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281644(CHEMBL355867 | N*1*-[(1S,2S,4S)-1-Cyclohexylmethyl...)
Affinity DataKi:  14nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi:  15nMAssay Description:Binding affinity to 5HT7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281643((2S,4S,5S)-5-Acetylamino-6-cyclohexyl-4-hydroxy-2-...)
Affinity DataKi:  16nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281652((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-{(...)
Affinity DataKi:  30nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGenome polyprotein(Human rhinovirus B)
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi:  30nMAssay Description:Tested for the inhibition of HIV-2 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281639((2S,4S,5S)-6-Cyclohexyl-5-hexanoylamino-4-hydroxy-...)
Affinity DataKi:  47nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  50nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281646((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-(2...)
Affinity DataKi:  61nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281637((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-{(...)
Affinity DataKi:  61nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGenome polyprotein(Human rhinovirus B)
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  65nMAssay Description:Compound was evaluated for the inhibition of HIV-2 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281645((2S,4S,5S)-6-Cyclohexyl-5-(3,3-dimethyl-butyrylami...)
Affinity DataKi:  75nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi:  76nMAssay Description:Binding affinity to adrenergic Alpha-1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  90nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  100nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi:  103nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13614(2-(carboxymethoxy)-5-[(2S)-2-(pentylcarbamoyl)-2-[...)
Affinity DataKi:  120nM ΔG°:  -39.1kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi:  142nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin EMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGenome polyprotein(Human rhinovirus B)
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  170nMAssay Description:Compound was evaluated for the inhibition of HIV-2 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi:  180nMAssay Description:Binding affinity to 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  200nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to Cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281636((S)-N*1*-((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-...)
Affinity DataKi:  212nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to reninMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13611(2-(carboxymethoxy)-5-[(2S)-2-[(2S)-2-(3-formamidop...)
Affinity DataKi:  250nM ΔG°:  -37.3kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50212827(CHEMBL3350189)
Affinity DataKi:  265nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to pepsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281638((2S,4S,5S)-6-Cyclohexyl-4-hydroxy-5-{(S)-3-(1H-imi...)
Affinity DataKi:  290nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to pepsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPepsin A(Porcine)
TBA

Curated by ChEMBL
LigandPNGBDBM50281642(((1S,2S,4S)-1-Cyclohexylmethyl-2-hydroxy-5-methyl-...)
Affinity DataKi:  330nMAssay Description:Compound was evaluated for aspartyl protease inhibition selectivity relative to pepsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281650((2S,4S,5S)-5-Amino-6-cyclohexyl-4-hydroxy-2-isopro...)
Affinity DataKi:  800nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281649((S)-2-((2S,4S,5S)-5-{(S)-3-Carbamoyl-2-[(quinoline...)
Affinity DataKi: >1.00E+3nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50281647((2S,4S,5S)-5-Acetylamino-6-cyclohexyl-4-hydroxy-2-...)
Affinity DataKi: >1.00E+3nMAssay Description:Evaluated for inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to dopamine D4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to dopamine D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323402(4-((3-(2,5-dimethoxyphenyl)pyrrolidin-1-yl)methyl)...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to adrenergic alpha-1b receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50323401(4-((3-(2-fluoro-6-methoxyphenoxy)azetidin-1-yl)met...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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