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Found 28 with Last Name = 'coyne' and Initial = 'ag'
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527800(CHEMBL4591748)
Affinity DataIC50:  250nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527797(CHEMBL4435863)
Affinity DataIC50:  310nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527801(CHEMBL4444080)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527798(CHEMBL4439827)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527796(CHEMBL4473331)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169700(CHEMBL3806115)
Affinity DataIC50:  1.13E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527802(CHEMBL4541593)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169702(CHEMBL3805279)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169698(CHEMBL3806191)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169702(CHEMBL3805279)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169700(CHEMBL3806115)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169698(CHEMBL3806191)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169702(CHEMBL3805279)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169700(CHEMBL3806115)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169698(CHEMBL3806191)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169700(CHEMBL3806115)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169698(CHEMBL3806191)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169702(CHEMBL3805279)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50527799(CHEBI:60704 | CHEMBL2387748)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of hexahistidine-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21(DE3) at preincubated for 10 mins with NADH...More data for this Ligand-Target Pair
TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM222346(CYP144A1 ligand, 1)
Affinity DataKd:  8.20E+4nMpH: 7.0Assay Description:Optical titrations to determine the binding affinity (KD values) of ligands were carried out on a Cary 60 UV−visible spectrophotometer (Varian,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM222349(CYP144A1 ligand, 4)
Affinity DataKd:  2.30E+5nMpH: 7.0Assay Description:Optical titrations to determine the binding affinity (KD values) of ligands were carried out on a Cary 60 UV−visible spectrophotometer (Varian,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM7886(1-PIM | 1-phenyl-1H-imidazole | 1-phenylimidazole ...)
Affinity DataKd:  2.90E+5nMpH: 7.0Assay Description:Optical titrations to determine the binding affinity (KD values) of ligands were carried out on a Cary 60 UV−visible spectrophotometer (Varian,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMycocyclosin synthase(Mycobacterium tuberculosis)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM31774(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Affinity DataKd:  73nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv wild type CYP121 by titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM222348(CYP144A1 ligand, 3)
Affinity DataKd:  1.40E+5nMpH: 7.5 T: 2°CAssay Description:ITC binding isotherms were recorded on a MicroCal ITC200 instrument (MalvernInstruments). Titrations were conducted at 25 °C by injecting aliquots (2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMycocyclosin synthase(Mycobacterium tuberculosis)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM31772(1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl...)
Affinity DataKd:  73nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv wild type CYP121 by titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMycocyclosin synthase(Mycobacterium tuberculosis)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM31773(ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...)
Affinity DataKd:  73nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv wild type CYP121 by titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM222347(CYP144A1 ligand, 2)
Affinity DataKd:  2.00E+5nMpH: 7.0Assay Description:Optical titrations to determine the binding affinity (KD values) of ligands were carried out on a Cary 60 UV−visible spectrophotometer (Varian,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytochrome P450 144 [31-434](Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataKd:  2.98E+6nMpH: 7.0Assay Description:Optical titrations to determine the binding affinity (KD values) of ligands were carried out on a Cary 60 UV−visible spectrophotometer (Varian,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed