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Found 142 with Last Name = 'dean' and Initial = 'm'
TargetMelanocortin receptor 4(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50128358(CHEMBL3629347)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human recombinant melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099623(4-[2-(4,4-Dimethyl-pent-1-ynyl)-cyclopropyl]-1H-im...)
Affinity DataKi:  0.180nMAssay Description:Ability to displace [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50176065(4-DAMP | 4-Diphenylacetoxy-1,1-dimethyl-piperidini...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]4-DAMP from human recombinant Muscarinic acetylcholine receptor M3 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50008735((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
Affinity DataKi:  0.270nMAssay Description:Displacement of [3H]methyl-spiperone from human recombinant D2S receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099622(1-Cyclohexylmethyl-3-[2-(1H-imidazol-4-yl)-cyclopr...)
Affinity DataKi:  0.400nMAssay Description:Ability to displace [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]U 69593 from rat recombinant kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Affinity DataKi:  0.710nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM28582(1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | CHE...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50233962(CHEMBL4068783)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50176062(3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]nisoxetine from human recombinant norepinephrine transporter expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175531(CHEMBL199156 | N-Hydroxy-2-(4-trifluoromethyl-benz...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175545(CHEMBL197685 | N-Hydroxycarbamoylmethyl-4-trifluor...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175544(CHEMBL198664 | N-Hydroxy-4-oxo-4-(4-trifluoromethy...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175561(CHEMBL198988 | N-Hydroxy-3-(4-trifluoromethyl-benz...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50005534(1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine ...)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]BTCP from human recombinant dopamine transporter expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50071496(CHEMBL73053 | N-(4-Chloro-benzyl)-2-[4-(1H-imidazo...)
Affinity DataKi:  7nMAssay Description:Ability to displace [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175557(CHEMBL194570 | N-Hydroxy-2-[4-(pyridin-4-yloxy)-be...)
Affinity DataKi:  8.20nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175550(CHEMBL198377 | N-Hydroxy-4-oxo-4-[4-(pyridin-4-ylo...)
Affinity DataKi:  8.20nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175541(CHEMBL438261 | N-Hydroxycarbamoylmethyl-4-(pyridin...)
Affinity DataKi:  8.20nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175529(CHEMBL383560 | N-Hydroxy-3-[4-(pyridin-4-yloxy)-be...)
Affinity DataKi:  8.20nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50050183((4-Iodo-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Affinity DataKi:  12nMAssay Description:Ability to displace [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099624((4-Chloro-phenyl)-acetic acid 3-(1H-imidazol-4-yl)...)
Affinity DataKi:  14nMAssay Description:Ability to displace [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]pirenzepine from human recombinant Muscarinic acetylcholine receptor M1 expressed in CHO cells after 60 mins by scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175551(CHEMBL366010 | N-Hydroxy-4-(4-methoxy-phenyl)-4-ox...)
Affinity DataKi:  33nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175547(CHEMBL198048 | N-Hydroxycarbamoylmethyl-4-methoxy-...)
Affinity DataKi:  33nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175543(CHEMBL198662 | N-Hydroxy-3-(4-methoxy-benzenesulfo...)
Affinity DataKi:  33nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
Affinity DataKi:  33nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT6 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175536(3-[4-(4-Chloro-phenoxy)-benzenesulfonyl]-N-hydroxy...)
Affinity DataKi:  70nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175540(4-(4-Chloro-phenoxy)-N-hydroxycarbamoylmethyl-benz...)
Affinity DataKi:  70nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175527(2-[4-(4-Chloro-phenoxy)-benzenesulfonylamino]-N-hy...)
Affinity DataKi:  70nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175554(4-[4-(4-Chloro-phenoxy)-phenyl]-N-hydroxy-4-oxo-bu...)
Affinity DataKi:  70nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  130nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT5a receptor in HEK293 cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175538(CHEMBL372377 | N-Hydroxy-4-[4-(4-imidazol-1-yl-phe...)
Affinity DataKi:  224nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175539(CHEMBL198393 | N-Hydroxy-3-[4-(4-imidazol-1-yl-phe...)
Affinity DataKi:  224nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175530(4-(4-Imidazol-1-yl-phenoxy)-piperidine-1-carboxyli...)
Affinity DataKi:  224nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175546(CHEMBL373285 | N-Hydroxy-2-[4-(4-imidazol-1-yl-phe...)
Affinity DataKi:  224nMAssay Description:Binding affinity towards (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM181119(US9138393, Cimetidine | US9144538, Cimetidine)
Affinity DataKi:  490nMAssay Description:Displacement of [125I]APT from human recombinant histamine H2 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50128358(CHEMBL3629347)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of human recombinant melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50176065(4-DAMP | 4-Diphenylacetoxy-1,1-dimethyl-piperidini...)
Affinity DataIC50:  0.310nMAssay Description:Displacement of [3H]4-DAMP from human recombinant Muscarinic acetylcholine receptor M3 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataIC50:  0.470nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Affinity DataIC50:  0.520nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataIC50:  0.680nMAssay Description:Displacement of [3H]U 69593 from rat recombinant kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50008735((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
Affinity DataIC50:  0.810nMAssay Description:Displacement of [3H]methyl-spiperone from human recombinant D2S receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175564(CHEMBL198634 | N-Hydroxy-2-(7-oxo-7,8-dihydro-6H-q...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175534(CHEMBL370842 | N-Hydroxy-3-(7-oxo-7,8-dihydro-6H-q...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175542(7-Oxo-7,8-dihydro-6H-quinolizine-4-carboxylic acid...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against (MMP-1) matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

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