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Found 198 with Last Name = 'dee' and Initial = 'mf'
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150407(CHEMBL180086 | N-[1-(4-Fluoro-phenyl)-ethyl]-N''-(...)
Affinity DataKi:  2nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150408(CHEMBL182937 | N-[2-(4-Fluoro-phenoxy)-ethyl]-N''-...)
Affinity DataKi:  2nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150413(CHEMBL413049 | N-[2-(4-Fluoro-phenyl)-ethyl]-N''-[...)
Affinity DataKi:  2nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150412(CHEMBL183862 | N-(2-Phenoxy-ethyl)-N''-((S)-1-phen...)
Affinity DataKi:  3nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150410(CHEMBL182174 | N-(2-Phenoxy-ethyl)-N''-((S)-1-phen...)
Affinity DataKi:  3nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150417(CHEMBL182322 | N-[2-(4-Fluoro-phenoxy)-ethyl]-N''-...)
Affinity DataKi:  5nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150405(CHEMBL182797 | N-(2-Phenoxy-ethyl)-N''-(1-phenyl-e...)
Affinity DataKi:  8nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150421(CHEMBL183462 | N-[1-(4-Fluoro-phenyl)-ethyl]-N''-p...)
Affinity DataKi:  8nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150406(CHEMBL182418 | N-[(S)-1-(4-Fluoro-phenyl)-ethyl]-N...)
Affinity DataKi:  9nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150420(6-Fluoro-N-(2-phenoxy-ethyl)-N''-((S)-1-phenyl-eth...)
Affinity DataKi:  10nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150407(CHEMBL180086 | N-[1-(4-Fluoro-phenyl)-ethyl]-N''-(...)
Affinity DataKi:  10nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataKi:  19nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150413(CHEMBL413049 | N-[2-(4-Fluoro-phenyl)-ethyl]-N''-[...)
Affinity DataKi:  20nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150414(CHEMBL182840 | N,N-Dimethyl-N''-(2-phenoxy-ethyl)-...)
Affinity DataKi:  23nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150411(CHEMBL180946 | N-[2-(4-Fluoro-phenoxy)-ethyl]-N''-...)
Affinity DataKi:  36nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150409(6-Methyl-N-(2-phenoxy-ethyl)-N''-((S)-1-phenyl-eth...)
Affinity DataKi:  54nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150416(CHEMBL182121 | N-(1-Phenyl-ethyl)-N''-(3-phenyl-pr...)
Affinity DataKi:  60nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150406(CHEMBL182418 | N-[(S)-1-(4-Fluoro-phenyl)-ethyl]-N...)
Affinity DataKi:  160nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150413(CHEMBL413049 | N-[2-(4-Fluoro-phenyl)-ethyl]-N''-[...)
Affinity DataKi:  172nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150407(CHEMBL180086 | N-[1-(4-Fluoro-phenyl)-ethyl]-N''-(...)
Affinity DataKi:  380nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150410(CHEMBL182174 | N-(2-Phenoxy-ethyl)-N''-((S)-1-phen...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150408(CHEMBL182937 | N-[2-(4-Fluoro-phenoxy)-ethyl]-N''-...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150415(CHEMBL360374 | N-(2-Phenoxy-ethyl)-N''-((R)-1-phen...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150419(CHEMBL185560 | N-[1-(4-Fluoro-phenyl)-ethyl]-N''-(...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150408(CHEMBL182937 | N-[2-(4-Fluoro-phenoxy)-ethyl]-N''-...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150406(CHEMBL182418 | N-[(S)-1-(4-Fluoro-phenyl)-ethyl]-N...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150410(CHEMBL182174 | N-(2-Phenoxy-ethyl)-N''-((S)-1-phen...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50150418(CHEMBL183347 | N-[1-(4-Fluoro-phenyl)-ethyl]-N''-(...)
Affinity DataKi: >4.10E+4nMAssay Description:Binding affinity against 5-Hydroxy tryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50485806(CHEMBL2164125)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of human gamma-secretase expressed in IMR32 cell membranes using MBPC-125 Swedish as substrate assessed as inhibition of amyloid beta40 pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009806(CHEMBL20207 | [3-(7-Chloro-benzothiazol-2-ylmethyl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  1.90nMAssay Description:Compound was tested for the rate of reduction of glyceraldehyde by human placental aldose reductase.More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  1.90nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009763(CHEMBL20024 | [3-(4-Fluoro-benzothiazol-2-ylmethyl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009781(CHEMBL20169 | [3-(5-Bromo-benzothiazol-2-ylmethyl)...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  3.10nMAssay Description:In vitro inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  3.10nMAssay Description:Compound was tested for the inhibition of the rat lens aldose reductase using the substrate as glucose.More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50008471(CHEMBL143234 | [3-(5,7-Difluoro-benzooxazol-2-ylme...)
Affinity DataIC50:  3.20nMAssay Description:In vitro inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009828(CHEMBL20015 | [3-(4-Chloro-benzothiazol-2-ylmethyl...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009784(CHEMBL278991 | [3-(5,7-Dichloro-benzothiazol-2-ylm...)
Affinity DataIC50:  4nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM50477715(CHEMBL248647)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta40 production after 19 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009750(CHEMBL282689 | [3-(4,7-Difluoro-benzothiazol-2-ylm...)
Affinity DataIC50:  5nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009759(CHEMBL20518 | [3-(5-Chloro-7-fluoro-benzothiazol-2...)
Affinity DataIC50:  5nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009774(CHEMBL20161 | [3-(5,7-Dimethyl-benzothiazol-2-ylme...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009749(CHEMBL416001 | [3-(7-Chloro-5-fluoro-benzothiazol-...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009757(CHEMBL20637 | [3-(5,7-Difluoro-benzothiazol-2-ylme...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50008441(CHEMBL422647 | [4-Oxo-3-(3-o-tolyl-[1,2,4]oxadiazo...)
Affinity DataIC50:  6.40nMAssay Description:In vitro inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50008480(CHEMBL341864 | {3-[3-(2-Bromo-phenyl)-[1,2,4]oxadi...)
Affinity DataIC50:  6.5nMAssay Description:In vitro inhibitory activity against aldose reductase isolated from human placentaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009804(CHEMBL283996 | [3-(5-Fluoro-benzothiazol-2-ylmethy...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009829(CHEMBL20197 | [3-(5-Chloro-benzothiazol-2-ylmethyl...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009769((4-Oxo-3-thiazolo[5,4-b]pyridin-2-ylmethyl-3,4-dih...)
Affinity DataIC50:  10nMAssay Description:Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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