Found 113 with Last Name = 'di matteo' and Initial = 'f' TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 490nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 570nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 850nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 910nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 950nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 1.98E+3nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 2.12E+3nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno
Curated by ChEMBL
University Of Salerno
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
Affinity DataIC50: 2.37E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant SARS-CoV-2 MPro transfected in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2 a...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant SARS-CoV-2 MPro transfected in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2 a...More data for this Ligand-Target Pair
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant SARS-CoV-2 MPro transfected in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2 a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 2.93E+3nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 3.86E+3nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 4.87E+3nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
Affinity DataIC50: 6.49E+3nMAssay Description:Inhibition of C-terminal His6-tagged recombinant SARS-CoV-2 MPro transfected in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2 a...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: 9.02E+3nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples
Curated by ChEMBL
University Federico Ii Of Naples
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
