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Found 15 with Last Name = 'ding' and Initial = 'hx'
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Affinity DataKi:  0.0850nMAssay Description:Displacement of [3H]Spiperone from dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]Spiperone from human dopamine D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]Spiperone from human D2S receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315426((1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4...)
Affinity DataKi:  1.10nMAssay Description:Competitive inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-alpha-methylglucoside uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50559516(GSK-189075 | GSK-189075A | GSK189075A | Remogliflo...)
Affinity DataKi:  12nMAssay Description:Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscleMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))TBA
LigandPNGBDBM50559516(GSK-189075 | GSK-189075A | GSK189075A | Remogliflo...)
Affinity DataKi:  4.52E+3nMAssay Description:Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50152828(Apatinib | YN-968D1)
Affinity DataIC50:  1nMAssay Description:Inhibition of VEGF2 receptor (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335784(2-[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant DPP4 using Gly-Pro-7-amido-4-methyl-coumarin as substrate incubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Seattle Genetics

Curated by ChEMBL
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human recombinant DPP4 using Gly-Pro-7-amido-4-methyl-coumarin as substrate incubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50152829(CHEMBL3780740)
Affinity DataIC50:  18nMAssay Description:Agonist activity at PPAR-gamma receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Pharmaphase

Curated by ChEMBL
LigandPNGBDBM50293282(CHEMBL504535 | Imrecoxib)
Affinity DataIC50:  18nMAssay Description:Inhibition of LPS-induced COX-2 in peritoneal macrophage of C57BL/J6 mouse assessed as prostaglandin E2 formation preincubated for 1 hr followed by L...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50152829(CHEMBL3780740)
Affinity DataIC50:  20nMAssay Description:Agonist activity at PPAR-alpha receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Shenogen Pharma Group

Curated by ChEMBL
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...)
Affinity DataIC50:  21nMAssay Description:Inhibition of wild type BRAF (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Mus musculus)
Pharmaphase

Curated by ChEMBL
LigandPNGBDBM50293282(CHEMBL504535 | Imrecoxib)
Affinity DataIC50:  115nMAssay Description:Inhibition of calcimycin-induced COX-1 in peritoneal macrophage of C57BL/J6 mouse assessed as 6-Keto prostaglandin F1alpha formation preincubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed