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Found 183 with Last Name = 'dorner-ciossek' and Initial = 'c'
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156246(US9018391, 8)
Affinity DataIC50:  1.90nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111911(US8623901, 239)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150700(US8981112, 7 | US9526727, 7 | US9949975, Example 7)
Affinity DataIC50:  2nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150700(US8981112, 7 | US9526727, 7 | US9949975, Example 7)
Affinity DataIC50:  2nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150700(US8981112, 7 | US9526727, 7 | US9949975, Example 7)
Affinity DataIC50:  2nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156243(US9018391, 5)
Affinity DataIC50:  2.60nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156242(US9018391, 4)
Affinity DataIC50:  2.70nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111910(US8623901, 234)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150705(US8981112, 12 | US9526727, 12 | US9949975, Example...)
Affinity DataIC50:  3nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156241(US9018391, 3)
Affinity DataIC50:  3nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150705(US8981112, 12 | US9526727, 12 | US9949975, Example...)
Affinity DataIC50:  3nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150705(US8981112, 12 | US9526727, 12 | US9949975, Example...)
Affinity DataIC50:  3nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156245(US9018391, 7)
Affinity DataIC50:  3.40nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111932(US8623901, 261)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150704(US8981112, 11 | US9526727, 11 | US9949975, Example...)
Affinity DataIC50:  4nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150704(US8981112, 11 | US9526727, 11 | US9949975, Example...)
Affinity DataIC50:  4nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150704(US8981112, 11 | US9526727, 11 | US9949975, Example...)
Affinity DataIC50:  4nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156252(US9018391, 14)
Affinity DataIC50:  4.5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111892(US8623901, 220)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111896(US8623901, 223)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111904(US8623901, 230-1)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111905(US8623901, 230-2)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111912(US8623901, 240)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111928(US8623901, 256)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150697(US8981112, 4 | US9526727, 4)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150701(US8981112, 8 | US9526727, 8 | US9949975, Example 8)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150707(US8981112, 14 | US9526727, 14 | US9949975, Example...)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150714(US8981112, 21 | US9526727, 21 | US9949975, Example...)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150717(US8981112, 24 | US9526727, 24 | US9949975, Example...)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150697(US8981112, 4 | US9526727, 4)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150701(US8981112, 8 | US9526727, 8 | US9949975, Example 8)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150707(US8981112, 14 | US9526727, 14 | US9949975, Example...)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150714(US8981112, 21 | US9526727, 21 | US9949975, Example...)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150717(US8981112, 24 | US9526727, 24 | US9949975, Example...)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM389136(US9949975, Example 4)
Affinity DataIC50:  5nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150701(US8981112, 8 | US9526727, 8 | US9949975, Example 8)
Affinity DataIC50:  5nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150707(US8981112, 14 | US9526727, 14 | US9949975, Example...)
Affinity DataIC50:  5nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150714(US8981112, 21 | US9526727, 21 | US9949975, Example...)
Affinity DataIC50:  5nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150717(US8981112, 24 | US9526727, 24 | US9949975, Example...)
Affinity DataIC50:  5nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111894(US8623901, 221)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111898(US8623901, 225)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111901(US8623901, 228)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111907(US8623901, 230-5)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM111913(US8623901, 241)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150712(US8981112, 19 | US9526727, 19 | US9949975, Example...)
Affinity DataIC50:  6nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150720(US8981112, 27 | US9526727, 27 | US9949975, Example...)
Affinity DataIC50:  6nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150712(US8981112, 19 | US9526727, 19 | US9949975, Example...)
Affinity DataIC50:  6nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150720(US8981112, 27 | US9526727, 27 | US9949975, Example...)
Affinity DataIC50:  6nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50210579((2S,5S,8S,11R,13S,14S,17S,20S,23S)-23-amino-2-benz...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human BACE1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50210579((2S,5S,8S,11R,13S,14S,17S,20S,23S)-23-amino-2-benz...)
Affinity DataIC50:  6nMAssay Description:Inhibition of full-domain of BACE1 expressed in HEK393 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

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