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Found 188 with Last Name = 'dunn' and Initial = 'wj'
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083672(18-methyl-10-oxa-6,7,18-triazahexacyclo[9.9.1.01,9...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity towards human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083671(19-methyl-11-oxa-6,8,19-triazahexacyclo[10.9.1.01,...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity towards human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083668(7,19-dimethyl-11-oxa-6,8,19-triazahexacyclo[10.9.1...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity towards human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083670(19-methyl-7-phenyl-11-oxa-6,8,19-triazahexacyclo[1...)
Affinity DataKi:  6.5nMAssay Description:Binding affinity towards human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083670(19-methyl-7-phenyl-11-oxa-6,8,19-triazahexacyclo[1...)
Affinity DataKi:  7.30nMAssay Description:Binding affinity towards human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083669(7-amino-19-methyl-11-oxa-6,8,19-triazahexacyclo[10...)
Affinity DataKi:  7.30nMAssay Description:Binding affinity towards human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083671(19-methyl-11-oxa-6,8,19-triazahexacyclo[10.9.1.01,...)
Affinity DataKi:  12nMAssay Description:Agonistic activity against human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083672(18-methyl-10-oxa-6,7,18-triazahexacyclo[9.9.1.01,9...)
Affinity DataKi:  12nMAssay Description:Agonistic activity against human opioid Mu receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083672(18-methyl-10-oxa-6,7,18-triazahexacyclo[9.9.1.01,9...)
Affinity DataKi:  12nMAssay Description:Binding affinity towards human opioid Kappa receptor transfected into Chinese hamster ovary (CHO) cells using [3H]U69,593 as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083671(19-methyl-11-oxa-6,8,19-triazahexacyclo[10.9.1.01,...)
Affinity DataKi:  19nMAssay Description:Binding affinity towards human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083669(7-amino-19-methyl-11-oxa-6,8,19-triazahexacyclo[10...)
Affinity DataKi:  19nMAssay Description:Binding affinity towards human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083669(7-amino-19-methyl-11-oxa-6,8,19-triazahexacyclo[10...)
Affinity DataKi:  21nMAssay Description:Binding affinity towards human opioid Kappa receptor transfected into Chinese hamster ovary (CHO) cells using [3H]U69,593 as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083668(7,19-dimethyl-11-oxa-6,8,19-triazahexacyclo[10.9.1...)
Affinity DataKi:  24nMAssay Description:Binding affinity towards human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083670(19-methyl-7-phenyl-11-oxa-6,8,19-triazahexacyclo[1...)
Affinity DataKi:  45nMAssay Description:Binding affinity towards human opioid Kappa receptor transfected into Chinese hamster ovary (CHO) cells using [3H]U69,593 as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50083668(7,19-dimethyl-11-oxa-6,8,19-triazahexacyclo[10.9.1...)
Affinity DataKi:  69nMAssay Description:Agonistic activity against human opioid Delta receptor transfected into Chinese hamster ovary (CHO) cells using [3H]-Cl-DPDPE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Illinois At Chicago 60612

Curated by ChEMBL
LigandPNGBDBM50027970(5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-di...)
Affinity DataIC50:  3nMAssay Description:Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Illinois At Chicago 60612

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  5.90nMAssay Description:Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Illinois At Chicago 60612

Curated by ChEMBL
LigandPNGBDBM50404462(4-Hydroxytrimethoprim | CHEMBL1181)
Affinity DataIC50:  11nMAssay Description:Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50174850(3-(9H-fluoren-2-yl)-8-methyl-8-aza-bicyclo[3.2.1]o...)
Affinity DataIC50:  14.5nMAssay Description:Displacement of [3H]Citalopram from human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Illinois At Chicago 60612

Curated by ChEMBL
LigandPNGBDBM50405965(CHEMBL287241)
Affinity DataIC50:  18nMAssay Description:Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018292(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018304(11-(2-{2-[(Cycloheptyl-methyl-amino)-methyl]-piper...)
Affinity DataIC50:  30nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Illinois At Chicago 60612

Curated by ChEMBL
LigandPNGBDBM50405982(CHEMBL56602)
Affinity DataIC50:  35nMAssay Description:Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018302(9-Chloro-11-[2-(2-diethylaminomethyl-piperidin-1-y...)
Affinity DataIC50:  40nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018056((AF-DX 116) 11-[2-(2-Diethylaminomethyl-piperidin-...)
Affinity DataIC50:  50nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018291(11-{2-[2-(3-Diethylamino-propyl)-piperidin-1-yl]-a...)
Affinity DataIC50:  60nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018314(11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperi...)
Affinity DataIC50:  60nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018304(11-(2-{2-[(Cycloheptyl-methyl-amino)-methyl]-piper...)
Affinity DataIC50:  70nMAssay Description:Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018294(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Affinity DataIC50:  70nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50174847(3-(1H-indol-3-yl)-8-methyl-8-aza-bicyclo[3.2.1]oct...)
Affinity DataIC50:  72.6nMAssay Description:Displacement of [3H]Citalopram from human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Illinois At Chicago 60612

Curated by ChEMBL
LigandPNGBDBM50138701(6-Methyl-5-(3,4,5-trimethoxy-benzyl)-pyrimidine-2,...)
Affinity DataIC50:  100nMAssay Description:Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018306(8-Chloro-11-[2-(2-diethylaminomethyl-piperidin-1-y...)
Affinity DataIC50:  100nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018298(11-(2-{2-[(Butyl-methyl-amino)-methyl]-piperidin-1...)
Affinity DataIC50:  100nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018293(11-(2-{2-[(Ethyl-methyl-amino)-methyl]-piperidin-1...)
Affinity DataIC50:  120nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018297(11-[2-(2-Dimethylaminomethyl-piperidin-1-yl)-acety...)
Affinity DataIC50:  140nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018314(11-(2-{2-[(Cyclohexyl-methyl-amino)-methyl]-piperi...)
Affinity DataIC50:  150nMAssay Description:Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018305(8-Bromo-11-[2-(2-diethylaminomethyl-piperidin-1-yl...)
Affinity DataIC50:  150nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018299(11-[2-(2-Diethylaminomethyl-pyrrolidin-1-yl)-acety...)
Affinity DataIC50:  150nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018313(11-[2-(3-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Affinity DataIC50:  170nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018291(11-{2-[2-(3-Diethylamino-propyl)-piperidin-1-yl]-a...)
Affinity DataIC50:  200nMAssay Description:Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018296(11-[2-(2-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Affinity DataIC50:  200nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018298(11-(2-{2-[(Butyl-methyl-amino)-methyl]-piperidin-1...)
Affinity DataIC50:  200nMAssay Description:Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018300(11-[3-(2-Diethylaminomethyl-piperidin-1-yl)-propio...)
Affinity DataIC50:  220nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018313(11-[2-(3-Diethylaminomethyl-piperidin-1-yl)-acetyl...)
Affinity DataIC50:  300nMAssay Description:Inhibition of rat submandibular muscarinic (M3) receptor isolated from tissue homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Illinois At Chicago 60612

Curated by ChEMBL
LigandPNGBDBM50404463(CHEMBL339058)
Affinity DataIC50:  302nMAssay Description:Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018307(11-{2-[2-(2-Diethylamino-ethyl)-piperidin-1-yl]-ac...)
Affinity DataIC50:  330nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Illinois At Chicago 60612

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataIC50:  398nMAssay Description:Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Illinois At Chicago 60612

Curated by ChEMBL
LigandPNGBDBM50405966(CHEMBL56101)
Affinity DataIC50:  398nMAssay Description:Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50018056((AF-DX 116) 11-[2-(2-Diethylaminomethyl-piperidin-...)
Affinity DataIC50:  400nMAssay Description:Inhibition of muscarinic (M2) receptor isolated from rat atriaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
University Of Illinois At Chicago 60612

Curated by ChEMBL
LigandPNGBDBM50406000(CHEMBL19293)
Affinity DataIC50:  501nMAssay Description:Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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