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Found 906 with Last Name = 'engle' and Initial = 'a'
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036427(CHEMBL350265 | [3,5-Dibromo-4-(4-hydroxy-3-isoprop...)
Affinity DataIC50:  0.100nMAssay Description:Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036401(CHEMBL163221 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241077(CHEMBL4060815)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18865(3-{3,5-dibromo-4-[4-hydroxy-3-(propan-2-yl)phenoxy...)
Affinity DataIC50:  0.110nMAssay Description:Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036399(Axitirome | CHEMBL159682 | N-(4-{3-[(4-Fluoro-phen...)
Affinity DataIC50:  0.140nMAssay Description:Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18862(2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]ac...)
Affinity DataIC50:  0.150nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036402(CHEMBL46882 | N-[3,5-dimethyl-4-(4'-hydroxy-3'-iso...)
Affinity DataIC50:  0.190nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241058(CHEMBL4104440)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241059(CHEMBL4069496)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241013(CHEMBL4066023)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50425360(CHEMBL2316207)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241078(CHEMBL4073561)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036418(CHEMBL350049 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Affinity DataIC50:  0.230nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036423(CHEMBL164421 | N-[4-(4-Hydroxy-3-isopropyl-phenoxy...)
Affinity DataIC50:  0.260nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036411(CHEMBL163324 | N-{3,5-Dichloro-4-[3-(4-chloro-benz...)
Affinity DataIC50:  0.270nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241010(CHEMBL4074237)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of P38 alpha MAPK in human whole blood assessed as reduction in TNF-alpha release after 10 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241055(CHEMBL4066347)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241017(CHEMBL4101643)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241062(CHEMBL4100394)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50266912(CHEMBL4089892)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of recombinant human GST-tagged wild type EGFR ( 668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474994(Bisarylmaleimide 1)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory concentration to inhibit Ser396 phosphorylation of tau, a natural substrate of GSK-3 in SY5Y cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50266914(CHEMBL4071827)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of recombinant human GST-tagged wild type EGFR ( 668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50234890(CHEMBL4077018)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant 6x-His-tagged JNK3 (39 to 402 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50266911(CHEMBL4061829)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of recombinant human GST-tagged wild type EGFR ( 668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036410(CHEMBL159976 | [4-(4-Hydroxy-3-isopropyl-phenoxy)-...)
Affinity DataIC50:  0.310nMAssay Description:Ability to inhibit the bound [125I]L-T3 rat liver Nuclear L-triiodothyronine receptor is determined in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036424(CHEMBL159334 | N-{3,5-Dichloro-4-[3-(4-fluoro-benz...)
Affinity DataIC50:  0.370nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241014(CHEMBL4087408)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241020(CHEMBL4072910)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241061(CHEMBL4089021)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241060(CHEMBL4096722)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241032(CHEMBL4082939)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036408(CHEMBL161828 | N-{4-[3-(4-Chloro-benzyl)-4-hydroxy...)
Affinity DataIC50:  0.430nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50266932(CHEMBL4082764)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of wild-type EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50266907(CHEMBL4101719)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of wild-type EGFR (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of wild-type EGFR (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241016(CHEMBL4077602)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241000(CHEMBL4092372)
Affinity DataIC50:  0.600nMAssay Description:Opioid receptor binding affinity in rat brain membrane preparations by the displacement of [3H]- DPDPE (Opioid receptor delta 1-selective radioligand...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50234889(CHEMBL4062023)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant 6x-His-tagged JNK3 (39 to 402 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as reduction in A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241045(CHEMBL4103539)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241027(CHEMBL4064695)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241038(CHEMBL4071095)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241037(CHEMBL4076170)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036417(CHEMBL423977 | N-{3,5-Dichloro-4-[3-(4-fluoro-benz...)
Affinity DataIC50:  0.680nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036417(CHEMBL423977 | N-{3,5-Dichloro-4-[3-(4-fluoro-benz...)
Affinity DataIC50:  0.680nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150699(3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of Glycogen synthase kinase-3 beta dependent Tau protein serine-396 phosphorylation in human SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241011(CHEMBL4102854)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]DSLET from delta opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241023(CHEMBL4103149)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]DSLET from delta opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard-Karls-Universitaet Tuebingen

Curated by ChEMBL
LigandPNGBDBM50241018(CHEMBL4075759)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of P38 alpha MAPK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(RAT)
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036404(CHEMBL159595 | N-(4-{3-[(4-Fluoro-phenyl)-hydroxy-...)
Affinity DataIC50:  0.800nMAssay Description:In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475025(CHEMBL181339)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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