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Found 261 with Last Name = 'erickson' and Initial = 'jw'
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM200((2S)-N-[(2S,3R,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[...)
Affinity DataKi:  0.00400nM ΔG°:  -66.1kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073270(CHEMBL333781 | {2-[(1S,3S,4S)-1-Benzyl-3-hydroxy-5...)
Affinity DataKi:  0.0100nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM198((2S)-N-[(2S,3S,4S,5S)-3,4-dihydroxy-5-[(2S)-3-meth...)
Affinity DataKi:  0.0110nM ΔG°:  -63.6kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM199((2S)-N-[(2S,3R,4S,5S)-3,4-dihydroxy-5-[(2S)-3-meth...)
Affinity DataKi:  0.0120nM ΔG°:  -63.4kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073266(CHEMBL119898 | {2-[(1S,3S,4S)-1-Benzyl-4-((2S,3S)-...)
Affinity DataKi:  0.0200nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
Technical University of LÓDz

LigandPNGBDBM86658(3-Hexanol derivative, 4)
Affinity DataKi:  0.0210nM IC50:  0.170nMAssay Description:The Ki value were determine by a fluorometric assay with the fluorogenic and chromogenic substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073250(CHEMBL333420 | {2-[(1S,3S,4S)-1-Benzyl-4-((R)-2-et...)
Affinity DataKi:  0.0300nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073253(CHEMBL278935 | {2-[(1S,3S,4S)-1-Benzyl-3-hydroxy-5...)
Affinity DataKi:  0.0300nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM430(3-[(2-tert-butyl-4-hydroxy-5-methylphenyl)sulfanyl...)
Affinity DataKi:  0.0300nM ΔG°:  -62.5kJ/molepH: 6.2 T: 2°CAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073269((2-{(1S,3S,4S)-1-Benzyl-3-hydroxy-5-phenyl-4-[(R)-...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073254(Anthranilamide derivative | CHEMBL408110)
Affinity DataKi:  0.0600nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073252(CHEMBL324157 | {2-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4...)
Affinity DataKi:  0.0600nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073265((2-{(1S,2S,3R,4S)-1-Benzyl-2,3-dihydroxy-5-phenyl-...)
Affinity DataKi:  0.0700nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073254(Anthranilamide derivative | CHEMBL408110)
Affinity DataKi:  0.0700nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50285701(Anthranilamide derivative | CHEMBL313767)
Affinity DataKi:  0.0700nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM2204((3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-phenylsu...)
Affinity DataKi:  0.0900nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM2208((6S)-3-{[2-tert-butyl-4-(hydroxymethyl)-5-methylph...)
Affinity DataKi:  0.0900nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073268(CHEMBL331294 | {2-[(1S,2S,3R,4S)-1-Benzyl-2,3-dihy...)
Affinity DataKi:  0.0900nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50041043((1-{(1S,2S,3R,4S)-1-Benzyl-2,3-dihydroxy-4-[3-meth...)
Affinity DataKi:  0.0900nMAssay Description:Compound was evaluated for the inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM2206((6S)-6-[2-(4-aminophenyl)ethyl]-3-{[2-tert-butyl-4...)
Affinity DataKi:  0.110nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM197((2S)-N-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[(2S)-3-meth...)
Affinity DataKi:  0.110nMAssay Description:Inhibitory activity of the compound was measured against wild-type HIV-1 proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM197((2S)-N-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[(2S)-3-meth...)
Affinity DataKi:  0.112nM ΔG°:  -57.7kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073263(CHEMBL117629 | {2-[(1S,3S,4S)-4-(3-Amino-2-methyl-...)
Affinity DataKi:  0.120nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073244(CHEMBL332825 | [2-((1S,3S,4S)-1-Benzyl-4-tert-buto...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073262(CHEMBL333290 | [2-((1S,2S,3R,4S)-1-Benzyl-4-tert-b...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041045((4S,6S)-4-Ethylamino-7,7-dioxo-6-propyl-4,5,6,7-te...)
Affinity DataKi:  0.140nMAssay Description:Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM197((2S)-N-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[(2S)-3-meth...)
Affinity DataKi:  0.150nMAssay Description:Compound was evaluated for the inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50041023((1-{(1S,2S,3S,4S)-1-Benzyl-2,3-dihydroxy-4-[3-meth...)
Affinity DataKi:  0.160nMAssay Description:Compound was evaluated for the inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50064201(1N-benzyl-2N-[1-benzyl-4-(2-benzylcarbamoyl-3-meth...)
Affinity DataKi:  0.160nMAssay Description:Inhibitory activity of the compound was measured against wild-type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041037((4S,6R)-4-Ethylamino-7,7-dioxo-6-propyl-4,5,6,7-te...)
Affinity DataKi:  0.170nMAssay Description:Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50064202(1N-benzyl-2N-[1-benzyl-4-(2-benzylcarbamoylcyclopr...)
Affinity DataKi:  0.170nMAssay Description:Inhibitory activity of the compound was measured against wild-type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM2533(3-{[2-tert-butyl-4-(hydroxymethyl)-5-methylphenyl]...)
Affinity DataKi:  0.170nM ΔG°:  -58.0kJ/molepH: 6.2 T: 2°CAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50041035(CHEMBL269401 | N-{(1S,2R,3R,4S)-1-Benzyl-2,3-dihyd...)
Affinity DataKi:  0.180nMAssay Description:Compound was evaluated for the inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50041032((1-{(1S,2R,3R,4S)-1-Benzyl-2,3-dihydroxy-4-[3-meth...)
Affinity DataKi:  0.190nMAssay Description:Compound was evaluated for the inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50285698(Anthranilamide derivative | CHEMBL315500)
Affinity DataKi:  0.260nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073248(CHEMBL119745 | {2-[(1S,3S,4S)-1-Benzyl-3-hydroxy-4...)
Affinity DataKi:  0.270nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041027((4S,6S)-6-Ethyl-4-ethylamino-7,7-dioxo-4,5,6,7-tet...)
Affinity DataKi:  0.300nMAssay Description:Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50064199(1N-benzyl-2N-[1-benzyl-4-(3-benzylcarbamoyl-2,2-di...)
Affinity DataKi:  0.310nMAssay Description:Inhibitory activity of the compound was measured against wild-type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHIV-1 protease(Human immunodeficiency virus)
Technical University of LÓDz

LigandPNGBDBM86657(3-Hexanol derivative, 3)
Affinity DataKi:  0.320nM IC50:  0.630nMAssay Description:The Ki value were determine by a fluorometric assay with the fluorogenic and chromogenic substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM10884((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Affinity DataKi:  0.370nMAssay Description:Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073249(CHEMBL331199 | {2-[(1S,3S,4S)-4-(3-Amino-benzoylam...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073243((2-{(1S,2S,3R,4S)-1-Benzyl-2,3-dihydroxy-4-[(isoxa...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Nci-Fcrdc

LigandPNGBDBM2536(6-Alkyl-6-phenethyldihydropyrone 13y | 6-[2-(4-ami...)
Affinity DataKi:  0.430nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50285700(Anthranilamide derivative | CHEMBL315742)
Affinity DataKi:  0.450nMAssay Description:Tested for inhibition of HIV protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073259(CHEMBL333407 | [2-((1S,2R,3S,4S)-1-Benzyl-4-tert-b...)
Affinity DataKi:  0.450nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50064203(1N-benzyl-2N-[1-benzyl-4-(2-benzylcarbamoyl-3-meth...)
Affinity DataKi:  0.470nMAssay Description:Inhibitory activity of the compound was measured against wild-type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073261(CHEMBL116482 | {2-[(1S,2S,3R,4S)-1-Benzyl-2,3-dihy...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041029((S)-4-Isobutylamino-7,7-dioxo-4,5,6,7-tetrahydro-7...)
Affinity DataKi:  0.610nMAssay Description:Compound was evaluated for the affinity towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073251(CHEMBL118396 | {2-[(1S,3S,4S)-1-Benzyl-3-hydroxy-5...)
Affinity DataKi:  0.620nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Aids Drug Screening And Development Laboratory

Curated by ChEMBL
LigandPNGBDBM50073247(CHEMBL118513 | {2-[(1S,2S,4S)-1-Benzyl-2-hydroxy-4...)
Affinity DataKi:  0.680nMAssay Description:Inhibitory activity against HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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