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Found 366 with Last Name = 'fairlamb' and Initial = 'ah'
TargetPteridine reductase(Trypanosoma brucei brucei)
University of Dundee

LigandPNGBDBM31801(2-aminobenzimidazole deriv., 12)
Affinity DataKi:  7nM ΔG°:  -46.2kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
TargetPteridine reductase(Trypanosoma brucei brucei)
University of Dundee

LigandPNGBDBM31800(2-aminobenzimidazole deriv., 11)
Affinity DataKi:  47nM ΔG°:  -41.5kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354279(CHEMBL1836603)
Affinity DataKi:  190nMAssay Description:Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354268(CHEMBL1836570)
Affinity DataKi:  270nMAssay Description:Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354299(CHEMBL1836378)
Affinity DataKi:  320nMAssay Description:Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University of Dundee

LigandPNGBDBM31798(2-aminobenzimidazole deriv., 9)
Affinity DataKi:  400nM ΔG°:  -36.3kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354257(CHEMBL1836559)
Affinity DataKi:  440nMAssay Description:Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
TargetPteridine reductase(Trypanosoma brucei brucei)
University of Dundee

LigandPNGBDBM31799(2-aminobenzimidazole deriv., 10)
Affinity DataKi:  510nM ΔG°:  -35.7kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354279(CHEMBL1836603)
Affinity DataKi:  1.46E+3nMAssay Description:Mixed type inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354268(CHEMBL1836570)
Affinity DataKi:  1.78E+3nMAssay Description:Mixed type inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354257(CHEMBL1836559)
Affinity DataKi:  2.27E+3nMAssay Description:Mixed type inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50117542(2-Amino-4-[1-(hydroxycarbamoylmethyl-carbamoyl)-3-...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibitory constant against amidase free Glutathionylspermidine Synthetase mutant (C79A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118638(2-[(S)-2-((S)-4-Amino-4-carboxy-butyrylamino)-4-me...)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118638(2-[(S)-2-((S)-4-Amino-4-carboxy-butyrylamino)-4-me...)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118640((S)-2-Amino-4-[1-((S)-(S)-2-amino-1-carboxy-ethylc...)
Affinity DataKi:  7.20E+3nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118640((S)-2-Amino-4-[1-((S)-(S)-2-amino-1-carboxy-ethylc...)
Affinity DataKi:  7.20E+3nMAssay Description:In vitro binding affinity for Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University of Dundee

LigandPNGBDBM31795(2-aminobenzimidazole deriv., 6)
Affinity DataKi:  9.80E+3nM ΔG°:  -28.4kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118642(5-Amino-2-[(S)-2-((S)-4-amino-4-carboxy-butyrylami...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118642(5-Amino-2-[(S)-2-((S)-4-amino-4-carboxy-butyrylami...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118643((S)-2-Amino-4-[1-((S)-(S)-3-amino-1-carboxy-propyl...)
Affinity DataKi:  1.04E+4nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118643((S)-2-Amino-4-[1-((S)-(S)-3-amino-1-carboxy-propyl...)
Affinity DataKi:  1.04E+4nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University of Dundee

LigandPNGBDBM31794(2-aminobenzimidazole deriv., 4 | 5-Chloro-1H-benzo...)
Affinity DataKi:  1.06E+4nM ΔG°:  -28.2kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataKi:  1.08E+4nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (T. cruzi) Trypanothione reductase (linear competitive type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118644((S)-2-Amino-4-[1-((S)-(S)-1-carboxy-2-hydroxy-ethy...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118644((S)-2-Amino-4-[1-((S)-(S)-1-carboxy-2-hydroxy-ethy...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50062260(CHEMBL38403 | [3-(2-Chloro-phenothiazin-10-yl)-pro...)
Affinity DataKi:  1.87E+4nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (T. cruzi) Trypanothione reductase (linear competitive type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University of Dundee

LigandPNGBDBM31791(2-aminobenzothiazole deriv., 2)
Affinity DataKi:  2.11E+4nM ΔG°:  -26.5kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM78433(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Affinity DataKi:  2.12E+4nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (T. cruzi) Trypanothione reductase (linear competitive type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM79181(10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoro...)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (T. cruzi) Trypanothione reductase (linear competitive type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University of Dundee

LigandPNGBDBM31797(2-aminobenzimidazole deriv., 8)
Affinity DataKi:  2.39E+4nM ΔG°:  -26.2kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118641(6-Amino-2-[(S)-2-((S)-4-amino-4-carboxy-butyrylami...)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118641(6-Amino-2-[(S)-2-((S)-4-amino-4-carboxy-butyrylami...)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM67544(N,N-dimethyl-3-[2-(trifluoromethyl)-10-phenothiazi...)
Affinity DataKi:  3.02E+4nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (T. cruzi) Trypanothione reductase (linear competitive type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118639(6-(4-Amino-butylamino)-2-[(S)-2-((S)-4-amino-4-car...)
Affinity DataKi:  3.20E+4nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118639(6-(4-Amino-butylamino)-2-[(S)-2-((S)-4-amino-4-car...)
Affinity DataKi:  3.20E+4nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118645(2-[(S)-2-((S)-4-Amino-4-carboxy-butyrylamino)-4-me...)
Affinity DataKi:  3.30E+4nMAssay Description:Tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50118645(2-[(S)-2-((S)-4-Amino-4-carboxy-butyrylamino)-4-me...)
Affinity DataKi:  3.30E+4nMAssay Description:Inhibitory constant of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)
Affinity DataKi:  5.91E+4nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (T. cruzi) Trypanothione reductase (linear competitive type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50117547(2-Amino-4-[3-methyl-1-(phosphonomethyl-carbamoyl)-...)
Affinity DataKi:  6.00E+4nMAssay Description:Inhibition constant of the compound was evaluated against enzyme Glutathionylspermidine Synthetase wild-type enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50288580((S)-4-Amino-4-[(S)-3-methyl-1-(phosphonomethyl-car...)
Affinity DataKi:  6.00E+4nMAssay Description:Compound was tested for linear non-competitive inhibitory activity against glutathionylspermidine synthetase.More data for this Ligand-Target Pair
In DepthDetails Article
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50117544(2-amino-4-(1-dihydroxyboronylmethylcarbamoyl-3-met...)
Affinity DataKi:  8.10E+4nMAssay Description:Concentration of the compound required for the inhibition of enzyme Glutathionylspermidine Synthetase wild-type enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50117544(2-amino-4-(1-dihydroxyboronylmethylcarbamoyl-3-met...)
Affinity DataKi:  8.10E+4nMAssay Description:Inhibition constant of the compound was evaluated against enzyme Glutathionylspermidine Synthetase wild-type enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50062261(CHEMBL829 | Dimethyl-(2-methyl-3-phenothiazin-10-y...)
Affinity DataKi:  1.27E+5nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (T. cruzi) Trypanothione reductase (linear competitive type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University of Dundee

LigandPNGBDBM31793(2-aminobenzothiazole deriv., 3)
Affinity DataKi:  1.41E+5nM ΔG°:  -21.8kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University of Dundee

LigandPNGBDBM31796(2-aminobenzimidazole deriv., 7)
Affinity DataKi: >2.00E+5nM ΔG°: >-21.0kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50017696((2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiaz...)
Affinity DataKi:  2.16E+5nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (T. cruzi) Trypanothione reductase (linear competitive type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University of Dundee

LigandPNGBDBM7960(1H-1,3-benzodiazol-2-amine | 2-Aminobenzimidazole ...)
Affinity DataKi:  2.88E+5nM ΔG°:  -20.1kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University Of Antwerp (Uia)

Curated by ChEMBL
LigandPNGBDBM50288579((S)-4-Amino-4-[(S)-2-methyl-1-(phosphonomethyl-car...)
Affinity DataKi:  2.90E+5nMAssay Description:Compound was tested for linear non-competitive inhibitory activity against glutathionylspermidine synthetase.More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50108994(CHEMBL3600555)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins prior to substrate addition by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50108990(CHEMBL3600551)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins prior to substrate addition by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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