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Found 138 with Last Name = 'fenaux' and Initial = 'm'
TargetC-C chemokine receptor type 7(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of CCR7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of ACC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of ACC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511117(CHEMBL4557289)
Affinity DataIC50:  3nMAssay Description:Inhibition of ACC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511117(CHEMBL4557289)
Affinity DataIC50:  3nMAssay Description:Inhibition of ACC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 7(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306033(Cenicriviroc | TAK-652 | TBR-652)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of CCR7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306033(Cenicriviroc | TAK-652 | TBR-652)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of CCR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM319585(US10174007, Example 4 | US10787438, Example 4 | US...)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511118(CHEMBL4456029)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant FLAG-tagged human DGAT2 expressed in SF9 cells after 1 hr by TopCount assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataIC50:  27nMAssay Description:Inhibition of CCR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511112(CHEMBL4567446)
Affinity DataIC50:  30nMAssay Description:Inhibition of ACC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511112(CHEMBL4567446)
Affinity DataIC50:  31nMAssay Description:Inhibition of ACC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant FLAG-tagged human DGAT2 expressed in SF9 cells after 1 hr by TopCount assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030474(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)
Affinity DataIC50:  80nMAssay Description:Activation of mouse liver PPARalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Rattus norvegicus)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241178(CHEMBL4070442)
Affinity DataIC50:  340nMAssay Description:Inhibition of rat KHKMore data for this Ligand-Target Pair
TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50274119(CHEMBL4126343)
Affinity DataIC50:  340nMAssay Description:Inhibition of Dengue virus 4 NS5 full length RdRp activity using RNA as template assessed as inhibition of NTPs incorporation after 90 mins by FAPA a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50274120(CHEMBL3417270)
Affinity DataIC50:  360nMAssay Description:Inhibition of Dengue virus 2 NS5 full length RdRp activity using RNA as template/primer assessed as inhibition of [alpha3P]GTP incorporation by SDS-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241178(CHEMBL4070442)
Affinity DataIC50:  450nMAssay Description:Inhibition of recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511110(CHEMBL4530491)
Affinity DataIC50:  579nMAssay Description:Inhibition of recombinant FLAG-tagged human DGAT2 expressed in SF9 cells after 1 hr by TopCount assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50274124(CHEMBL4125966 | US10793591, Compound 12)
Affinity DataIC50:  650nMAssay Description:Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50103521(Actos | CHEBI:8228 | Duetact | Pioglitazone | US10...)
Affinity DataIC50:  1.15E+3nMAssay Description:Activation of mouse liver PPARalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50164648(2'-deoxythymidine triphosphate | 5'-TTP | CHEMBL36...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human DNA polymerase-betaMore data for this Ligand-Target Pair
TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50274121(CHEMBL4127092)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50274122(CHEMBL4127819)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50274125(CHEMBL4127565)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511111(CHEMBL4476176)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of ACC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50274118(CHEMBL4127030 | US10793591, Compound 7a)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511111(CHEMBL4476176)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of ACC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50274117(CHEMBL4127921)
Affinity DataIC50:  1.59E+4nMAssay Description:Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50511113(CHEMBL4593380)
Affinity DataIC50:  1.83E+4nMAssay Description:Activation of mouse liver PPARalphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus)
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50274123(CHEMBL4129313)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50237537(CHEMBL4093601)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human DNA polymerase-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50399710(CHEMBL2178953)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of recombinant FLAG-tagged human DGAT1 expressed in SF9 cells after 1 hr by TopCount assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241205(CHEMBL1463512)
Affinity DataIC50:  3.19E+5nMAssay Description:Inhibition of recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKetohexokinase(Homo sapiens (Human))
Terns Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241206(CHEMBL1500542)
Affinity DataIC50:  3.19E+5nMAssay Description:Inhibition of recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652391(N-(4-((1-(tert-butyl)-2-methoxy-1H-benzo[d]imidazo...)
Affinity DataEC50:  3.00E+3nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor beta(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652399(N-(4-((3-(tert-butyl)-2-oxo-2,3-dihydro-1H-benzo[d...)
Affinity DataEC50:  290nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652399(N-(4-((3-(tert-butyl)-2-oxo-2,3-dihydro-1H-benzo[d...)
Affinity DataEC50:  3.30E+3nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor beta(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652405(N-(3,5-dichloro-4-((2-methoxy-1-(1-methylcycloprop...)
Affinity DataEC50:  60nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652405(N-(3,5-dichloro-4-((2-methoxy-1-(1-methylcycloprop...)
Affinity DataEC50:  1.40E+3nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor beta(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652406(2-(3,5-dichloro-4-((2-methoxy-1-(1-methylcycloprop...)
Affinity DataEC50:  40nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652406(2-(3,5-dichloro-4-((2-methoxy-1-(1-methylcycloprop...)
Affinity DataEC50:  700nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor beta(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652407(N-(3,5-dichloro-4-((3-(1-methylcyclopropyl)-2-oxo-...)
Affinity DataEC50:  210nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652407(N-(3,5-dichloro-4-((3-(1-methylcyclopropyl)-2-oxo-...)
Affinity DataEC50:  3.00E+3nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor beta(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652408(2-(3,5-dichloro-4-((3-(1-methylcyclopropyl)-2-oxo-...)
Affinity DataEC50:  60nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652408(2-(3,5-dichloro-4-((3-(1-methylcyclopropyl)-2-oxo-...)
Affinity DataEC50:  900nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor beta(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652409(2-(4-((1-(tert-butyl)-2-methoxy-1H-benzo[d] imidaz...)
Affinity DataEC50:  30nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetRetinoic acid receptor RXR-alpha/Thyroid hormone receptor alpha(Homo sapiens (Human))
Terns Pharmaceuticals

US Patent
LigandPNGBDBM652409(2-(4-((1-(tert-butyl)-2-methoxy-1H-benzo[d] imidaz...)
Affinity DataEC50:  400nMAssay Description:Test compounds were prepared as 10 mM DMSO stock solutions. The stock solution (45 uL) was transferred to a 384-well assay plate, and 3-fold, 10-poin...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
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