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Found 546 with Last Name = 'ferreira' and Initial = 'rs'
TargetCysteine protease(Trypanosoma brucei rhodesiense)TBA
LigandPNGBDBM50311245((S)-4-methyl-2-phenyl-N-(5-phenyl-1-(phenylsulfony...)
Affinity DataKi:  6nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris measured for 30 mins using Cbz-Phe-Arg-AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)TBA
LigandPNGBDBM50229129(4-Methyl-piperazine-1-carboxylic acid [(S)-1-((E)-...)
Affinity DataKi:  7nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris measured for 30 mins using Cbz-Phe-Arg-AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM31992(Dipeptidyl nitrile inhibitor, 25)
Affinity DataKi:  16nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50554308(CHEMBL4761511)
Affinity DataKi:  25nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin S(Homo sapiens (Human))TBA
LigandPNGBDBM50007619(CHEMBL3233083)
Affinity DataKi:  48nMAssay Description:Binding affinity to Cathepsin S (unknown origin) assessed as inhibition constant measured after 22 hrsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50554305(CHEMBL4776795)
Affinity DataKi:  63nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50554307(CHEMBL4784502)
Affinity DataKi:  63nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50554304(CHEMBL4752430)
Affinity DataKi:  63nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50322737(2-(2-chloro-5-(trifluoromethyl)phenylamino)-2-oxo-...)
Affinity DataKi:  70nMAssay Description:Inhibition of Trypanosoma cruzi cruzain assessed as Z-Phe-Arg-aminomethylcoumarin cleavage by competetive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50007630(CHEMBL3233095)
Affinity DataKi:  80nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50007630(CHEMBL3233095)
Affinity DataKi:  82nMAssay Description:Competitive inhibition of Trypanosoma cruzi cruzaine expressed in Escherichia coli SG13009 using Z-FR-AMC as substrate by Lineweaver-Burk plot analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50303409(4-amino-6-(diphenylamino)-1,3,5-triazine-2-carboni...)
Affinity DataKi:  180nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50554296(CHEMBL4799785)
Affinity DataKi:  199nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCathepsin S(Homo sapiens (Human))TBA
LigandPNGBDBM50007620(CHEMBL3233084)
Affinity DataKi:  220nMAssay Description:Binding affinity to Cathepsin S (unknown origin) assessed as inhibition constant measured after 22 hrsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)
Affinity DataKi:  251nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50502835(CHEMBL4463665)
Affinity DataKi:  251nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50611831(CHEMBL5285296)
Affinity DataKi:  251nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)TBA
LigandPNGBDBM50311245((S)-4-methyl-2-phenyl-N-(5-phenyl-1-(phenylsulfony...)
Affinity DataKi:  320nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))TBA
LigandPNGBDBM50007617(CHEMBL3233081)
Affinity DataKi:  360nMAssay Description:Binding affinity to Cathepsin S (unknown origin) assessed as inhibition constant measured after 22 hrsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50611830(CHEMBL5269694)
Affinity DataKi:  398nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  501nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50322741(2-(3-chloro-4-methoxyphenylamino)-2-oxoethyl 2-(1,...)
Affinity DataKi:  800nMAssay Description:Inhibition of Trypanosoma cruzi cruzain assessed as Z-Phe-Arg-aminomethylcoumarin cleavage by competetive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50397142(CHEMBL2172005)
Affinity DataKi:  1.26E+3nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50518231(CHEMBL597248 | GNF-Pf-4180 | MMV006169)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50518231(CHEMBL597248 | GNF-Pf-4180 | MMV006169)
Affinity DataKi:  1.40E+3nMAssay Description:Competitive inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50518231(CHEMBL597248 | GNF-Pf-4180 | MMV006169)
Affinity DataKi:  1.70E+3nMAssay Description:Competitive inhibition of Trypanosoma cruzi cruzain assessed as inhibition constant using varying levels of Z-FR-AMC as substrate by Michaelis-Menten...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50322742(CHEMBL1173694 | N-(2-(1H-benzo[d]imidazol-2-yl)eth...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50322743(8-chloro-N-(3-morpholinopropyl)-5H-pyrimido[5,4-b]...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi cruzain assessed as Z-Phe-Arg-aminomethylcoumarin cleavage by competetive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50322742(CHEMBL1173694 | N-(2-(1H-benzo[d]imidazol-2-yl)eth...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi cruzain assessed as Z-Phe-Arg-aminomethylcoumarin cleavage by competetive binding assayMore data for this Ligand-Target Pair
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50546138(CHEMBL4793916)
Affinity DataKi:  3.00E+3nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50575008(CHEMBL4851626)
Affinity DataKi:  3.20E+3nMAssay Description:Competitive inhibition of Trypanosoma cruzi cruzain assessed as inhibition constant using varying levels of Z-FR-AMC as substrate by Michaelis-Menten...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50322734(CHEMBL1172022 | N-(1-(2-(furan-2-yl)-2-(piperidin-...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi cruzain assessed as Z-Phe-Arg-aminomethylcoumarin cleavage by competetive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)TBA
LigandPNGBDBM50546136(CHEMBL531738)
Affinity DataKi:  1.00E+4nMAssay Description:Mixed inhibition of recombinant Trypanosoma brucei rhodesain expressed in Pichia pastoris by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50233289(CHEMBL1241726)
Affinity DataKi:  1.21E+4nMAssay Description:Competitive inhibition of recombinant Trypanosoma cruzi cruzain in presence of varying levels of Z-phe-Arg-amidomethylcoumarin substrate by Lineweave...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50295154(2-(2,5-dichlorophenylamino)-2-oxoethyl 2-aminonico...)
Affinity DataKi:  3.20E+4nMAssay Description:Competitive inhibition of Trypanosoma cruzi cruzain by Lineaweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50303420(6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50303422(6-(3-chlorophenylamino)-9-cyclopentyl-9H-purine-2-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50303421(6-(3-Chlorophenylamino)-9-ethyl-9H-purine-2-carbon...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50303434(4-(cyclopentylamino)-6-(3-nitrophenylamino)-1,3,5-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50303419(4-(2,2-difluoroethylamino)-6-(3,5-difluorophenylam...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50303410(4-(3-chlorophenylamino)-6-(cyclopentylamino)-1,3,5...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50303411(4-(3-bromophenylamino)-6-(cyclopentylamino)-1,3,5-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50126127(CHEMBL3628943)
Affinity DataIC50:  3nMAssay Description:Inhibition of Trypanosoma cruzi CruzainMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)TBA
LigandPNGBDBM12042((2R,3R)-3-{[(1S)-1-[(4-carbamimidamidobutyl)carbam...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesiense MVAT4 rhodesain expressed in Pichia pastoris using Z-FR-AMC as substrate by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50229129(4-Methyl-piperazine-1-carboxylic acid [(S)-1-((E)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Trypanosoma cruzi cruzain after 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50303417(4-(Cyclopentylamino)-6-(3,5-difluorophenylamino)-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)TBA
LigandPNGBDBM50229129(4-Methyl-piperazine-1-carboxylic acid [(S)-1-((E)-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain preincubated after 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50117291(CHEMBL3613587)
Affinity DataIC50:  8nMAssay Description:Inhibition of Trypanosoma cruzi catalytic activity of cruzain using Z-FR-AMC as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50058809(CHEMBL3329524)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)TBA
LigandPNGBDBM50303435(4-(cyclopentylamino)-6-(3-fluorophenylamino)-1,3,5...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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