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Found 116 with Last Name = 'flentge' and Initial = 'ca'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM520(1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[...)
Affinity DataKi:  0.0150nMAssay Description:Inhibition constant of ritonavir towards HIV protease was determinedMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM520(1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[...)
Affinity DataKi:  0.0200nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50267297(CHEMBL507731 | Methyl (S)-1-((2S,4S,5S)-5-((S)-2-(...)
Affinity DataKi:  18nMAssay Description:Inhibition of CYP3A4 (unknown origin) assessed as midazolam 1'- hydroxylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50267295(CHEMBL470508 | Methyl (S)-1-((2R,4S,5S)-4-Hydroxy-...)
Affinity DataKi:  66nMAssay Description:Inhibition of CYP3A4 (unknown origin) assessed as midazolam 1'- hydroxylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50267295(CHEMBL470508 | Methyl (S)-1-((2R,4S,5S)-4-Hydroxy-...)
Affinity DataKi:  540nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50267297(CHEMBL507731 | Methyl (S)-1-((2S,4S,5S)-5-((S)-2-(...)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50267297(CHEMBL507731 | Methyl (S)-1-((2S,4S,5S)-5-((S)-2-(...)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of cathepsin D (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50267295(CHEMBL470508 | Methyl (S)-1-((2R,4S,5S)-4-Hydroxy-...)
Affinity DataKi: >2.00E+4nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50063071(((1S,2S,4S)-1-Benzyl-2-hydroxy-4-{3-[3-(2-isopropy...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory concentration against purified recombinant HIV-1 protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50062997(((1S,2S,4S)-1-Benzyl-2-hydroxy-4-{2-[3-(2-isopropy...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory concentration against purified recombinant HIV-1 protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50062946(((1S,3S,4S)-1-Benzyl-3-hydroxy-4-{3-[3-(2-isopropy...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against purified recombinant HIV-1 protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285916(CHEMBL90751 | [(1S,2S,4S)-1-Benzyl-4-(2-chloro-4-h...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285903(CHEMBL93589 | [(1S,3S,4S)-1-Benzyl-4-(2-chloro-4-h...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50062994(((1S,3S,4S)-1-Benzyl-3-hydroxy-4-{2-[3-(2-isopropy...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against purified recombinant HIV-1 protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50062954(((1S,2S,4S)-1-Benzyl-2-hydroxy-4-{2-[3-isobutyl-3-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory concentration against purified recombinant HIV-1 protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285910(CHEMBL93718 | [(1S,3S,4S)-1-Benzyl-3-hydroxy-4-(3-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50062969(CHEMBL346943 | {(1S,3S,4S)-1-Benzyl-3-hydroxy-4-[2...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory concentration against purified recombinant HIV-1 protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50062941(((1S,3S,4S)-1-Benzyl-4-{2-[3-cyclopropyl-3-(2-isop...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory concentration against purified recombinant HIV-1 protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50062939(CHEMBL347824 | [(1S,2S,4S)-1-Benzyl-4-(2-{3-ethyl-...)
Affinity DataIC50:  2.30nMAssay Description:Inhibitory concentration against purified recombinant HIV-1 protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285911(CHEMBL90090 | [(1S,3S,4S)-4-(3-Amino-2-methyl-benz...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285890(CHEMBL93566 | [(1S,3S,4S)-4-(5-Amino-2-chloro-benz...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285913(CHEMBL327611 | [(1S,3S,4S)-1-Benzyl-3-hydroxy-4-(4...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285905(CHEMBL93540 | [(1S,3S,4S)-1-Benzyl-3-hydroxy-4-(4-...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285900(CHEMBL93481 | [(1S,3S,4S)-4-(4-Amino-2-chloro-benz...)
Affinity DataIC50:  3.40nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285897(CHEMBL273562 | [(1S,3S,4S)-1-Benzyl-3-hydroxy-4-(3...)
Affinity DataIC50:  3.40nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285906(CHEMBL328531 | [(1S,3S,4S)-1-Benzyl-4-(3,4-dihydro...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50062925(CHEMBL157673 | [(1S,2S,4S)-1-Benzyl-2-hydroxy-4-(2...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory concentration against purified recombinant HIV-1 protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285899(((1S,3S,4S)-4-Benzoylamino-1-benzyl-3-hydroxy-5-ph...)
Affinity DataIC50:  4.5nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM12210((2S)-N-[(2S,3R)-3-hydroxy-4-({4-[(1E)-(hydroxyimin...)
Affinity DataIC50:  5nMpH: 4.5 T: 2°CAssay Description:HIV-1 protease inhibition was measured by a fluorescence assay using recombinant HIV-1 protease. The reactions were initiated by the addition of 1 nM...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285889(((1S,3S,4S)-1-Benzyl-4-tert-butoxycarbonylamino-3-...)
Affinity DataIC50:  5.30nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285907(CHEMBL93323 | [(1S,3S,4S)-4-(3-Amino-2-chloro-benz...)
Affinity DataIC50:  5.30nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285892(((1S,3S,4S)-1-Benzyl-4-benzyloxycarbonylamino-3-hy...)
Affinity DataIC50:  5.60nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285915(CHEMBL91657 | [(1S,2S,4S)-4-(4-Amino-2-chloro-benz...)
Affinity DataIC50:  6.10nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285891(CHEMBL441065 | [(1S,3S,4S)-4-(4-Amino-3-methoxy-be...)
Affinity DataIC50:  7.5nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285908(CHEMBL90139 | [(1S,3S,4S)-4-(3-Amino-4-hydroxy-ben...)
Affinity DataIC50:  7.60nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50063021(((1S,3S,4S)-1-Benzyl-4-{2-[3-cyclopropyl-3-(2-isop...)
Affinity DataIC50:  9.40nMAssay Description:Inhibitory concentration against purified recombinant HIV-1 protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285893(CHEMBL90699 | [(1S,3S,4S)-1-Benzyl-4-(3,4-diamino-...)
Affinity DataIC50:  9.60nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285909(CHEMBL91443 | [(1S,3S,4S)-4-(4-Amino-3-hydroxy-ben...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285904(CHEMBL191849 | [(1S,2S,4S)-4-(4-Amino-3-methoxy-be...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285898(CHEMBL91601 | [(1S,3S,4S)-1-Benzyl-4-(2-chloro-5-h...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50062933(((1S,2S,4S)-1-Benzyl-4-{3-[3-cyclopropyl-3-(2-isop...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against purified recombinant HIV-1 protease using fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50250183(CHEMBL503188 | N-{3-[(4S)-4-Benzylamino-1-hydroxy-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of HCV1b Con1 NS5B assessed as [3H]UTP incorporation into RNA by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM12209((2S)-N-[(2S,3R)-3-hydroxy-4-{[4-(hydroxymethyl)ben...)
Affinity DataIC50:  16nMpH: 4.5 T: 2°CAssay Description:HIV-1 protease inhibition was measured by a fluorescence assay using recombinant HIV-1 protease. The reactions were initiated by the addition of 1 nM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM12213((2S)-N-[(2S,3R)-3-hydroxy-4-({3-[(1E)-(hydroxyimin...)
Affinity DataIC50:  16nMpH: 4.5 T: 2°CAssay Description:HIV-1 protease inhibition was measured by a fluorescence assay using recombinant HIV-1 protease. The reactions were initiated by the addition of 1 nM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50249586(CHEMBL504729 | N-{3-[4-[(2,6-Dimethylbenzyl)amino]...)
Affinity DataIC50:  19nMAssay Description:Inhibition of HCV1b Con1 NS5B assessed as [3H]UTP incorporation into RNA by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285896(CHEMBL90510 | [(1S,2S,4S)-4-(4-Amino-3-hydroxy-ben...)
Affinity DataIC50:  22nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285894(CHEMBL541982 | [(1S,3S,4S)-1-Benzyl-3-hydroxy-4-(3...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM12198((2S)-N-[(2S,3R)-4-[(4-aminobenzene)(2-methylpropyl...)
Affinity DataIC50:  31nMpH: 4.5 T: 2°CAssay Description:HIV-1 protease inhibition was measured by a fluorescence assay using recombinant HIV-1 protease. The reactions were initiated by the addition of 1 nM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285888(((1S,2S,4S)-4-Benzoylamino-1-benzyl-2-hydroxy-5-ph...)
Affinity DataIC50:  31nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285902(CHEMBL93120 | [(1S,3S,4S)-4-(3-Amino-2,6-dichloro-...)
Affinity DataIC50:  31nMAssay Description:Inhibitory activity against purified HIV proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
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