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Found 750 with Last Name = 'freeman' and Initial = 'sk'
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50034993((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...)
Affinity DataKi:  31nMAssay Description:Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50034993((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...)
Affinity DataKi:  31nMAssay Description:The Compound was tested for the inhibition potency against C. albicans N-myristoyltransferase (NMT) and reported as apparent KiMore data for this Ligand-Target Pair
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50034988(11-Amino-undecanoic acid {(S)-1-[(S)-5-amino-1-(2-...)
Affinity DataKi:  70nMAssay Description:Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50034988(11-Amino-undecanoic acid {(S)-1-[(S)-5-amino-1-(2-...)
Affinity DataKi:  90nMAssay Description:Apparent binding affinity against Human NMT.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50470170(CHEMBL54883)
Affinity DataKi:  130nMAssay Description:Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50470169(CHEMBL294596)
Affinity DataKi:  590nMAssay Description:Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50470171(CHEMBL299249)
Affinity DataKi:  760nMAssay Description:Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1/2(Homo sapiens (Human))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50470171(CHEMBL299249)
Affinity DataKi:  4.20E+3nMAssay Description:Apparent binding affinity against Human NMT.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase(Candida albicans (Yeast))
G.D. Searle And

Curated by ChEMBL
LigandPNGBDBM50291976(6-Amino-2-(2-{2-[2-[2-(2-amino-propionylamino)-4-m...)
Affinity DataKi:  1.53E+4nMAssay Description:The Compound was tested for the inhibition potency against C. albicans N-myristoyltransferase (NMT) and reported as apparent KiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316640(5-(4-(aminomethyl)piperidin-1-yl)-1-(2-ethoxyethyl...)
Affinity DataIC50:  0.00700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316638(1-(2-ethoxyethyl)-3-ethyl-N7-(4-methylpyridin-2-yl...)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316647(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316646(1-(1-(2-ethoxyethyl)-3-methyl-7-(4-methylpyridin-2...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316642((1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318137((R)-3-ethyl-5-(3-methylpiperazin-1-yl)-N-(pyrimidi...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316639(5-(4-(aminomethyl)piperidin-1-yl)-1-(2-ethoxyethyl...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316651(1-(2-ethoxyethyl)-3-ethyl-N-phenyl-5-(piperazin-1-...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316645(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316644(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318144(3-ethyl-N-(4-fluorophenyl)-5-(piperazin-1-yl)-1-(2...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316666(1-(2-ethoxyethyl)-3-ethyl-N5-methyl-N5-(1-methylpi...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141329(2-Benzenesulfonylamino-3-{4-[3-(1,4,5,6-tetrahydro...)
Affinity DataIC50:  0.110nMAssay Description:Binding affinity towards alpha V/beta3 receptor by solid-phase receptor binding assays (SPRA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141329(2-Benzenesulfonylamino-3-{4-[3-(1,4,5,6-tetrahydro...)
Affinity DataIC50:  0.120nMAssay Description:Binding affinity towards alpha V-beta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318136((R)-3-methyl-5-(3-methylpiperazin-1-yl)-N-(pyrimid...)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318135(3-ethyl-5-(piperazin-1-yl)-N-(pyrimidin-4-yl)-1-(2...)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141324(2-Isopropoxycarbonylamino-3-{2-methoxy-4-[3-(1,4,5...)
Affinity DataIC50:  0.160nMAssay Description:Binding affinity towards alpha V/beta3 receptor by solid-phase receptor binding assays (SPRA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316643(1-(1-(2-ethoxyethyl)-3-methyl-7-(4-methylpyridin-2...)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316663(1-(2-ethoxyethyl)-3-ethyl-N7-(4-methylpyridin-2-yl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141309(2-Benzenesulfonylamino-3-[4-(3-guanidino-benzoylam...)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity towards alpha V/beta3 receptor by solid-phase receptor binding assays (SPRA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209479((beta1S)-3-bromo-5-chloro-b-[[[[3-[(5-fluoro-1,4,5...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209482((3S)-3-(5-chloro-2-hydroxy-3-methylphenyl)-3-(2-(3...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50185450(3-(benzo[d][1,3]dioxol-5-yl)-4-(1-methyl-5-(2-(5,6...)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of alphavbeta3 integrin in 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177621((S)-3-(benzo[d][1,3]dioxol-5-yl)-4-(3-(4-(4-thiomo...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of Integrin alphav-beta3 receptor by SPRA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141325(2-Benzenesulfonylamino-3-{4-[3-(4,5-dihydro-1H-imi...)
Affinity DataIC50:  0.270nMAssay Description:Binding affinity towards alpha V/beta3 receptor by solid-phase receptor binding assays (SPRA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318138(3-ethyl-5-(piperazin-1-yl)-1-(2-propoxyethyl)-N-(p...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209471((3S)-3-(5-bromo-3-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209459((3R)-3-(2-(3-amino-5-(5-hydroxy-1,4,5,6-tetrahydro...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209446((3S)-3-(3,5-dichloro-2-hydroxyphenyl)-3-(2-(3-(5-h...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of alphaVbeta3 integrin receptor expressed in human 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141356(3-{3-Chloro-4-[3-(4,5-dihydro-1H-imidazol-2-ylamin...)
Affinity DataIC50:  0.310nMAssay Description:Binding affinity towards alpha V-beta1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177626(3-(benzo[d]oxazol-6-yl)-4-(3-(3-(5,6,7,8-tetrahydr...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of Integrin alphav-beta3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141355(3-[4-(3-Guanidino-benzoylamino)-2-methoxy-phenyl]-...)
Affinity DataIC50:  0.320nMAssay Description:Binding affinity towards alpha V/beta3 receptor by solid-phase receptor binding assays (SPRA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50185464(3-(benzo[d][1,3]dioxol-5-yl)-4-(3-(2-(5,6,7,8-tetr...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of alphavbeta3 integrin in 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316670(1-(2-ethoxyethyl)-3-methyl-N7-(4-methylpyridin-2-y...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141324(2-Isopropoxycarbonylamino-3-{2-methoxy-4-[3-(1,4,5...)
Affinity DataIC50:  0.350nMAssay Description:Binding affinity towards alpha V-beta1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50318148(3-ethyl-N5-methyl-N5-(1-methylpiperidin-4-yl)-N7-(...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50141355(3-[4-(3-Guanidino-benzoylamino)-2-methoxy-phenyl]-...)
Affinity DataIC50:  0.380nMAssay Description:Binding affinity towards alpha V-beta1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316655(1-(2-ethoxyethyl)-3-ethyl-N-(4-methylpyridin-2-yl)...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177628((S)-3-(benzo[d][1,3]dioxol-5-yl)-4-(3-(3-(5,6,7,8-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Integrin alphav-beta3 receptor by SPRA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316650(1-(2-ethoxyethyl)-3-ethyl-5-(piperazin-1-yl)-N-(py...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50316650(1-(2-ethoxyethyl)-3-ethyl-5-(piperazin-1-yl)-N-(py...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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