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Found 59 with Last Name = 'fritz' and Initial = 'je'
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106483(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-indol-4...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061306((3S,4aS,8aS)-2-[(2R,3R)-2-Hydroxy-3-(3-hydroxy-2-m...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061307(AG-1254 | CHEMBL128696 | N-[(1R,2R)-3-(2-tert-Buty...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106484(CHEMBL421287 | N-[3-(2-Dimethylamino-ethyl)-1H-ind...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi:  8.20nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1F receptor using [3H]-5-HT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061308((3S,4aS,8aS)-2-[(2R,3S)-2-Hydroxy-3-(3-hydroxy-2-m...)
Affinity DataKi:  21nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  25.7nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1F receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50061305((3S,4aS,8aS)-2-[(2R,3R)-2-Hydroxy-3-(3-hydroxy-2-m...)
Affinity DataKi:  98nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi:  265nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1A receptor was determined using [3H]-5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi:  380nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 4 receptor using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi:  676nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 2A receptor using [125I]DOI as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi:  1.06E+3nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]5-HT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi:  1.46E+3nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi:  1.62E+3nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1D receptor was determined using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi:  1.77E+3nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 6 receptor using [3H]LSD as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi:  2.20E+3nMAssay Description:Binding affinity towards human 5-HT2C receptor was determined using [125I]- DOI as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1E(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi: >4.83E+3nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1E receptor was determined using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi:  1.20E+4nMAssay Description:Binding affinity towards rat histamine H1 receptor was determined using [3H]pyrilamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi:  3.80E+4nMAssay Description:Binding affinity towards rat dopamine D2 receptor was determined using [3H]raclopride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-meth...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity towards rat dopamine receptor D1 was determined using [3H]SCH-23390 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50049319(CHEMBL42407 | Lanepitant | N-[(R)-1-{[Acetyl-(2-me...)
Affinity DataIC50:  0.230nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50213827(CHEMBL351834)
Affinity DataIC50: <0.25nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50213826(CHEMBL164045)
Affinity DataIC50: <0.25nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101033(CHEMBL43044 | N-[(R)-1-{[Acetyl-(2-methoxy-benzyl)...)
Affinity DataIC50:  0.430nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101037(CHEMBL47070 | N-[(R)-1-{[Acetyl-(2-methoxy-benzyl)...)
Affinity DataIC50:  0.480nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101030(CHEMBL296013 | N-[(R)-1-{[Acetyl-(2-chloro-benzyl)...)
Affinity DataIC50:  0.650nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101029(1N-{2-(1H-3-indolyl)-1-[2-methoxybenzyl(methyl)car...)
Affinity DataIC50:  0.820nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101031(1N-{2-(1H-3-indolyl)-1-[2-methoxybenzyl(methyl)car...)
Affinity DataIC50:  0.980nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286689((S)-N*1*-[(1R,2R)-3-(2-tert-Butylcarbamoyl-phenyl)...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286688((S)-2-Acetylamino-N*1*-[(1R,2R)-3-(2-tert-butylcar...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM3414((2S)-N-[(2S,3R)-4-[2-(tert-butylcarbamoyl)phenyl]-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286691((S)-N*1*-[(1R,2R)-3-((3S,4aS,8aS)-3-tert-Butylcarb...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286690(CHEMBL164158 | {(S)-1-[(1R,2R)-3-(2-tert-Butylcarb...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM3414((2S)-N-[(2S,3R)-4-[2-(tert-butylcarbamoyl)phenyl]-...)
Affinity DataIC50:  1.5nMAssay Description:Concentration required for in vitro inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50282667((S)-N*1*-[(1S,2R)-1-Benzyl-3-(2-tert-butylcarbamoy...)
Affinity DataIC50:  2.20nMAssay Description:Concentration required for in vitro inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101042(1N-{2-(1H-3-indolyl)-1-[2-methoxybenzyl(methyl)car...)
Affinity DataIC50:  3.20nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101034(1N-{2-(1H-3-indolyl)-1-[2-methoxybenzyl(methyl)car...)
Affinity DataIC50:  3.30nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50282663((S)-N*1*-[(1S,2R)-1-Benzyl-3-(2-tert-butylcarbamoy...)
Affinity DataIC50:  3.40nMAssay Description:Concentration required for in vitro inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50282665((S)-N*1*-[(1S,2R)-1-Benzyl-3-(1-tert-butylcarbamoy...)
Affinity DataIC50:  3.5nMAssay Description:Concentration required for in vitro inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101032(1N-{2-(1H-3-indolyl)-1-[2-methoxybenzyl(methyl)car...)
Affinity DataIC50:  3.5nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101035(1N-{2-(1H-3-indolyl)-1-[2-methoxybenzyl(methyl)car...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101040(1N-{2-(1H-3-indolyl)-1-[2-methoxybenzyl(methyl)car...)
Affinity DataIC50:  8.30nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101038(1N-{2-(1H-3-indolyl)-1-[2-methoxybenzyl(methyl)car...)
Affinity DataIC50:  9.70nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101041(1N-{2-(1H-3-indolyl)-1-[2-methoxybenzyl(methyl)car...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101036(1N-{2-(1H-3-indolyl)-1-[2-methoxybenzyl(methyl)car...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286684(CHEMBL159378 | {(S)-1-[(1R,2R)-3-(2-tert-Butylcarb...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286687((S)-2-Acetylamino-N*1*-[(1R,2R)-3-(2-tert-butylcar...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50101039(1N-{2-(1H-3-indolyl)-1-[2-methoxybenzyl(methyl)car...)
Affinity DataIC50:  24nMAssay Description:In vitro inhibition of binding of [125I]-Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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