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Found 578 with Last Name = 'gaonkar' and Initial = 's'
TargetToll-like receptor 7(Mus musculus)
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at gardiquimod stimulated TRL7 in mouse whole blood assessed as inhibition of IL-6 production by ELISA analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010376(CHEMBL3263618)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Athenex

Curated by ChEMBL
LigandPNGBDBM50567579(Encequidar | HM-30181 | HM30181 | HM30181AK | Pgp ...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of paclitaxel stimulated- P-gp ATPase activity (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM443496(US10660877, Example 73)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM443500(US10660877, Example 77)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at gardiquimod stimulated TRL7 in human PBMC cells assessed as inhibition of IL-6 production by ELISA analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010373(CHEMBL3263615)
Affinity DataIC50:  1nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM25142((3S,6S,9S,15aR)-9-[(2R)-butan-2-yl]-6-[(1-methoxy-...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM442004(US10660877, Example 31)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at gardiquimod stimulated TRL7 in human whole blood assessed as inhibition of IL-6 production by ELISA analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  1.80nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM441973(2-(2-fluoro-6-methylpyridin-4-yl)-3-isopropyl-5-(p...)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM443111(US10660877, Example 46)
Affinity DataIC50:  1.90nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010340(CHEMBL3263621)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50447299(CHEMBL3114208)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity after 100 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010377(CHEMBL3263619)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM442004(US10660877, Example 31)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM443496(US10660877, Example 73)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM443506(US10660877, Example 83)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010339(CHEMBL3263620)
Affinity DataIC50:  3nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM443500(US10660877, Example 77)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010338(CHEMBL3259858)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM441973(2-(2-fluoro-6-methylpyridin-4-yl)-3-isopropyl-5-(p...)
Affinity DataIC50:  3.80nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM441974(US10660877, Example 5)
Affinity DataIC50:  3.90nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50447303(CHEMBL3114202)
Affinity DataIC50:  4nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity after 100 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010371(CHEMBL3263613)
Affinity DataIC50:  4nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50:  4.20nMAssay Description:Antagonist activity at R848 stimulated TRL8 in human whole blood assessed as inhibition of IL-6 production by ELISA analysisMore data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010374(CHEMBL3263616)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  4.80nMAssay Description:Antagonist activity at TLR7 (unknown origin) in PBMC cells assessed as reduction of IL-6 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Athenex

Curated by ChEMBL
LigandPNGBDBM50206310(5-Methoxy-9-oxo-9,10-dihydro-acridine-4-carboxylic...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of paclitaxel stimulated- P-gp ATPase activity (unknown origin)More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50447301(CHEMBL3114206)
Affinity DataIC50:  5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity after 100 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50447300(CHEMBL3114207)
Affinity DataIC50:  5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity after 100 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010347(CHEMBL3263591)
Affinity DataIC50:  5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  5.10nMAssay Description:Antagonist activity at TLR8 in human whole blood cells assessed as inhibition of IL-6 production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM50543465(CHEMBL4636498)
Affinity DataIC50:  5.70nMAssay Description:Antagonist activity at TLR7 in human whole blood cells assessed as inhibition of gardiquimod induced IL-6 production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50447305(CHEMBL3114200)
Affinity DataIC50:  6nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity after 100 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM441974(US10660877, Example 5)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM442800(US10660877, Example 38)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010365(CHEMBL3263607)
Affinity DataIC50:  7nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010362(CHEMBL3263604)
Affinity DataIC50:  7nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM442804(US10660877, Example 39)
Affinity DataIC50:  7.20nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM441989(US10660877, Example 19)
Affinity DataIC50:  7.60nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Athenex

Curated by ChEMBL
LigandPNGBDBM50583070(CHEMBL5074763 | US11739089, Compound 30)
Affinity DataIC50:  8nMAssay Description:Inhibition of wild type human P-gp in human MES-SA/Dx5 cells incubated for 3 days by MTT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50447297(CHEMBL3114210)
Affinity DataIC50:  8nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity after 100 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010375(CHEMBL3263617)
Affinity DataIC50:  8nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca India

Curated by ChEMBL
LigandPNGBDBM50010364(CHEMBL3263606)
Affinity DataIC50:  8nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase B ATPase activity assessed as inorganic phosphate release using ATP as substrate by colorimetric ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM443498(US10660877, Example 75)
Affinity DataIC50:  8.20nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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