TargetDihydrofolate reductase(Homo sapiens (Human))
Janssen Research And Development
Curated by ChEMBL
Janssen Research And Development
Curated by ChEMBL
Affinity DataKi: 0.00600nMAssay Description:Binding affinity to DHFR (unknown origin) by NMR analysisMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of rat PDE10A by scintillation proximity assayMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson And Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of CETP (unknown origin)-mediated transfer of [3H]cholesteryl ester from HDL donar particles to LDL acceptor particles in presence of buff...More data for this Ligand-Target Pair
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson And Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of CETP (unknown origin)-mediated transfer of [3H]cholesteryl ester from HDL donar particles to LDL acceptor particlesMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Janssen Research & Development
Curated by ChEMBL
Janssen Research & Development
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant full length PDE10A expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of KHK-mediated conversion of D-fructose to fructose-1-phosphate after 60 mins by high throughput mass spectrometry analysisMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:An enzymatic assay was developed to measure KHK-mediated conversion of D-fructose to Fructose-1-P (F-1-P) using High Throughput Mass Spectroscopy (HT...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human ketohexokinase isoform C expressed in Escherichia coli BL21 (DE3) cells using D-fructose as substrate after 12 to 15 mins by fluo...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of KHK-mediated conversion of D-fructose to fructose-1-phosphate after 60 mins by high throughput mass spectrometry analysisMore data for this Ligand-Target Pair
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson And Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of human plasma-derived CETP activity by scintillation proximity assayMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of KHK-mediated conversion of D-fructose to fructose-1-phosphate after 60 mins by high throughput mass spectrometry analysisMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:An enzymatic assay was developed to measure KHK-mediated conversion of D-fructose to Fructose-1-P (F-1-P) using High Throughput Mass Spectroscopy (HT...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:An enzymatic assay was developed to measure KHK-mediated conversion of D-fructose to Fructose-1-P (F-1-P) using High Throughput Mass Spectroscopy (HT...More data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of KHK-mediated conversion of D-fructose to fructose-1-phosphate after 60 mins by high throughput mass spectrometry analysisMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research And Development
Curated by ChEMBL
TargetKetohexokinase(Homo sapiens (Human))
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Janssen Pharmaceutical Companies Of Johnson & Johnson
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of recombinant human hepatic KHKCMore data for this Ligand-Target Pair