TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.0800nMAssay Description:Inhibition Protein kinase C (PKC)More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Sprint Bioscience
Curated by ChEMBL
Sprint Bioscience
Curated by ChEMBL
Affinity DataIC50: <0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Sprint Bioscience
Curated by ChEMBL
Sprint Bioscience
Curated by ChEMBL
Affinity DataIC50: <0.100nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as concentration required to achieve half of the maximal stabilization of protein at 54 degC af...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Sprint Bioscience
Curated by ChEMBL
Sprint Bioscience
Curated by ChEMBL
Affinity DataIC50: <0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Sprint Bioscience
Curated by ChEMBL
Sprint Bioscience
Curated by ChEMBL
Affinity DataIC50: <0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Sprint Bioscience
Curated by ChEMBL
Sprint Bioscience
Curated by ChEMBL
Affinity DataIC50: <0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Sprint Bioscience
Curated by ChEMBL
Sprint Bioscience
Curated by ChEMBL
Affinity DataIC50: <0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Sprint Bioscience
Curated by ChEMBL
Sprint Bioscience
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Sprint Bioscience
Curated by ChEMBL
Sprint Bioscience
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Sprint Bioscience
Curated by ChEMBL
Sprint Bioscience
Curated by ChEMBL
Affinity DataIC50: <0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Sprint Bioscience
Curated by ChEMBL
Sprint Bioscience
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 4More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 6More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of Extracellular signal-regulated kinase 2 (Erk2)More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Sprint Bioscience
Curated by ChEMBL
Sprint Bioscience
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: <1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: <1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: <1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: <1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: <1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: <1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: <1nMAssay Description:A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...More data for this Ligand-Target Pair
Ligand Info
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation in MG63 cells in the absence of plasmaMore data for this Ligand-Target Pair
TargetSodium-dependent phosphate transport protein 2A(Homo sapiens)
Bayer Aktiengesellschaft
US Patent
Bayer Aktiengesellschaft
US Patent
Affinity DataIC50: <1.60nMAssay Description:For measuring Npt2a activity in a cell based assay, a stable CHO cell line with inducible Npt2a expression was generated. Therefore, CHO T-Rex cells ...More data for this Ligand-Target Pair
TargetSodium-dependent phosphate transport protein 2A(Homo sapiens)
Bayer Aktiengesellschaft
US Patent
Bayer Aktiengesellschaft
US Patent
Affinity DataIC50: <1.60nMAssay Description:For measuring Npt2a activity in a cell based assay, a stable CHO cell line with inducible Npt2a expression was generated. Therefore, CHO T-Rex cells ...More data for this Ligand-Target Pair
TargetSodium-dependent phosphate transport protein 2A(Homo sapiens)
Bayer Aktiengesellschaft
US Patent
Bayer Aktiengesellschaft
US Patent
Affinity DataIC50: <1.60nMAssay Description:For measuring Npt2a activity in a cell based assay, a stable CHO cell line with inducible Npt2a expression was generated. Therefore, CHO T-Rex cells ...More data for this Ligand-Target Pair
TargetSodium-dependent phosphate transport protein 2A(Homo sapiens)
Bayer Aktiengesellschaft
US Patent
Bayer Aktiengesellschaft
US Patent
Affinity DataIC50: 1.60nMAssay Description:For measuring Npt2a activity in a cell based assay, a stable CHO cell line with inducible Npt2a expression was generated. Therefore, CHO T-Rex cells ...More data for this Ligand-Target Pair
TargetSodium-dependent phosphate transport protein 2A(Homo sapiens)
Bayer Aktiengesellschaft
US Patent
Bayer Aktiengesellschaft
US Patent
Affinity DataIC50: 1.90nMAssay Description:For measuring Npt2a activity in a cell based assay, a stable CHO cell line with inducible Npt2a expression was generated. Therefore, CHO T-Rex cells ...More data for this Ligand-Target Pair
TargetSodium-dependent phosphate transport protein 2A(Homo sapiens)
Bayer Aktiengesellschaft
US Patent
Bayer Aktiengesellschaft
US Patent
Affinity DataIC50: 2nMAssay Description:For measuring Npt2a activity in a cell based assay, a stable CHO cell line with inducible Npt2a expression was generated. Therefore, CHO T-Rex cells ...More data for this Ligand-Target Pair