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Found 219 with Last Name = 'grellier' and Initial = 'p'
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135635(2-[2-(Isothiazole-3-carbonyl)-pyrrolidine-1-carbon...)
Affinity DataKi:  0.260nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  0.280nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135637(1-{(S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-car...)
Affinity DataKi:  0.340nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135634((S)-2-[(S)-2-(5-Trimethylsilanyl-isoxazole-3-carbo...)
Affinity DataKi:  0.450nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  1.87nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  1.90nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of PKD2 ( assessed as residual activity at 1 uM ) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  3.30nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  4nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  4nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135636((S)-2-[(S)-2-(5-Cyano-isoxazole-3-carbonyl)-pyrrol...)
Affinity DataKi:  7.5nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  15nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  15nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human; Moderately activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135635(2-[2-(Isothiazole-3-carbonyl)-pyrrolidine-1-carbon...)
Affinity DataKi:  16nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135634((S)-2-[(S)-2-(5-Trimethylsilanyl-isoxazole-3-carbo...)
Affinity DataKi:  19nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135632((S)-2-[(S)-2-(Isoxazole-3-carbonyl)-pyrrolidine-1-...)
Affinity DataKi:  36nMAssay Description:In vitro inhibitory activity determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135636((S)-2-[(S)-2-(5-Cyano-isoxazole-3-carbonyl)-pyrrol...)
Affinity DataKi:  38nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135632((S)-2-[(S)-2-(Isoxazole-3-carbonyl)-pyrrolidine-1-...)
Affinity DataKi:  72nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette

Curated by ChEMBL
LigandPNGBDBM50481616(CHEMBL590127)
Affinity DataKi:  230nMAssay Description:Binding affinity to FPP site of human recombinant FTase by competitive Michaelis-Menten analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette

Curated by ChEMBL
LigandPNGBDBM50481625(CHEMBL599795)
Affinity DataKi:  260nMAssay Description:Binding affinity to FPP site of human recombinant FTase by competitive Michaelis-Menten analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette

Curated by ChEMBL
LigandPNGBDBM50481615(CHEMBL590126)
Affinity DataKi:  500nMAssay Description:Binding affinity to FPP site of human recombinant FTase by competitive Michaelis-Menten analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135631(3-[(S)-1-((S)-1-Benzyloxycarbonyl-pyrrolidine-2-ca...)
Affinity DataKi: >1.00E+3nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi; Moderately activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135631(3-[(S)-1-((S)-1-Benzyloxycarbonyl-pyrrolidine-2-ca...)
Affinity DataKi: >1.00E+3nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette

Curated by ChEMBL
LigandPNGBDBM50481616(CHEMBL590127)
Affinity DataKi:  5.60E+3nMAssay Description:Binding affinity to CaaX site of human recombinant FTase by non-competitive Michaelis-Menten analysis for enzyme-substrate-inhibitor complexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette

Curated by ChEMBL
LigandPNGBDBM50481616(CHEMBL590127)
Affinity DataKi:  7.70E+3nMAssay Description:Binding affinity to CaaX site of human recombinant FTase by non-competitive Michaelis-Menten analysis for enzyme-inhibitor complexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette

Curated by ChEMBL
LigandPNGBDBM50481615(CHEMBL590126)
Affinity DataKi:  1.50E+4nMAssay Description:Binding affinity to CaaX site of human recombinant FTase by non-competitive Michaelis-Menten analysis for enzyme-substrate-inhibitor complexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette

Curated by ChEMBL
LigandPNGBDBM50481615(CHEMBL590126)
Affinity DataKi:  1.70E+4nMAssay Description:Binding affinity to CaaX site of human recombinant FTase by non-competitive Michaelis-Menten analysis for enzyme-inhibitor complexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Saccharomyces cerevisiae (Baker's yeast))
Centre De Recherche De Gif

LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  0.780nMpH: 7.5Assay Description:Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123594((7-Chloro-quinolin-4-yl)-{3-[4-(3-dibutylamino-pro...)
Affinity DataIC50:  6.70nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50075135((S)-4-phenyl-1-(3-(pyrrolidine-1-carbonyl)-3,4-dih...)
Affinity DataIC50:  7nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50075132(2-(4-Methyl-cyclohexyl)-1-[(S)-3-(pyrrolidine-1-ca...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette

Curated by ChEMBL
LigandPNGBDBM50139469(CHEMBL3763335)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase alpha subunit/subunit beta(Trypanosoma brucei brucei)
Centre De Recherche De Gif

LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  10nMAssay Description:Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette

Curated by ChEMBL
LigandPNGBDBM50139637(CHEMBL3765675)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50075126(5-Phenyl-1-[(S)-3-(pyrrolidine-1-carbonyl)-3,4-dih...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123579(CHEMBL345958 | [3-(4-{3-[Bis-(4-nitro-benzyl)-amin...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Affinity DataIC50:  15nMAssay Description:Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50051539((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50075134(4-(4-Chloro-2-methyl-phenoxy)-1-[(S)-3-(pyrrolidin...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50075128(CHEMBL138674 | {6-Oxo-6-[(S)-3-(pyrrolidine-1-carb...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50075129(1-[(S)-3-(Pyrrolidine-1-carbonyl)-3,4-dihydro-1H-i...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50075125(((1S,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(pyrrolidine...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123587((7-Chloro-quinolin-4-yl)-(3-{4-[3-(cyclopropylmeth...)
Affinity DataIC50:  23.3nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50409777(CHEMBL2111198)
Affinity DataIC50:  23.5nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50075130(1-[(S)-3-(Pyrrolidine-1-carbonyl)-3,4-dihydro-1H-i...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123575((3-{4-[3-(Bis-cyclopropylmethyl-amino)-propyl]-pip...)
Affinity DataIC50:  27.1nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50131276(CHEMBL328470 | N-(3-{4-[3-(7-Chloro-quinolin-4-yla...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against mammalian Aminopeptidase N (APN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123577(CHEMBL152862 | Cyclopropanecarboxylic acid (3-{4-[...)
Affinity DataIC50:  34nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123561(CHEMBL149751 | N-(3-(4-(3-(7-chloroquinolin-4-ylam...)
Affinity DataIC50:  34.2nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistidine-rich protein PFHRP-II(Plasmodium falciparum)
Universit£

Curated by ChEMBL
LigandPNGBDBM50123569(CHEMBL357111 | N-(3-{4-[3-(7-Chloro-quinolin-4-yla...)
Affinity DataIC50:  35.6nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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