Affinity DataKi: 0.260nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
Affinity DataKi: 0.280nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
Affinity DataKi: 1.87nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Inhibition of PKD2 ( assessed as residual activity at 1 uM ) by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
Affinity DataKi: 7.5nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human; Moderately activeMore data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:In vitro inhibitory activity determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
Affinity DataKi: 72nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Affinity DataKi: 230nMAssay Description:Binding affinity to FPP site of human recombinant FTase by competitive Michaelis-Menten analysisMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Affinity DataKi: 260nMAssay Description:Binding affinity to FPP site of human recombinant FTase by competitive Michaelis-Menten analysisMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Affinity DataKi: 500nMAssay Description:Binding affinity to FPP site of human recombinant FTase by competitive Michaelis-Menten analysisMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi; Moderately activeMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Affinity DataKi: 5.60E+3nMAssay Description:Binding affinity to CaaX site of human recombinant FTase by non-competitive Michaelis-Menten analysis for enzyme-substrate-inhibitor complexMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Affinity DataKi: 7.70E+3nMAssay Description:Binding affinity to CaaX site of human recombinant FTase by non-competitive Michaelis-Menten analysis for enzyme-inhibitor complexMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Affinity DataKi: 1.50E+4nMAssay Description:Binding affinity to CaaX site of human recombinant FTase by non-competitive Michaelis-Menten analysis for enzyme-substrate-inhibitor complexMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Affinity DataKi: 1.70E+4nMAssay Description:Binding affinity to CaaX site of human recombinant FTase by non-competitive Michaelis-Menten analysis for enzyme-inhibitor complexMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Saccharomyces cerevisiae (Baker's yeast))
Centre De Recherche De Gif
Centre De Recherche De Gif
Affinity DataIC50: 0.780nMpH: 7.5Assay Description:Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...More data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase alpha subunit/subunit beta(Trypanosoma brucei brucei)
Centre De Recherche De Gif
Centre De Recherche De Gif
Affinity DataIC50: 10nMAssay Description:Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Centre De Recherche De Gif-Sur-Yvette
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 23.3nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 23.5nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 27.1nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against mammalian Aminopeptidase N (APN)More data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 34.2nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair
Affinity DataIC50: 35.6nMAssay Description:In vitro inhibition of beta-hematin formationMore data for this Ligand-Target Pair