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Found 1268 with Last Name = 'guo' and Initial = 'h'
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23334(3-(pyridin-3-yl)propyl (2S)-1-(3,3-dimethyl-2-oxop...)
Affinity DataKi:  0.0100nMAssay Description:Ability to inhibit peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362366(CHEMBL1939755)
Affinity DataKi:  0.0450nMAssay Description:Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344100(2-((2R)-1-((4-methylphenyl)sulfonyl)-3-oxo-2-piper...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362363(CHEMBL1939758)
Affinity DataKi:  0.197nMAssay Description:Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50272456(2-((R)-3-oxo-1-tosyl-1,2,3,4-tetrahydroquinoxalin-...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362361(CHEMBL1939760)
Affinity DataKi:  0.480nMAssay Description:Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362362(CHEMBL1939759)
Affinity DataKi:  0.560nMAssay Description:Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068597(1-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-acetyl]-piper...)
Affinity DataKi:  1nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113103(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  1nMAssay Description:Ability to inhibit peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362364(CHEMBL1939757)
Affinity DataKi:  1.25nMAssay Description:Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362365(CHEMBL1939756)
Affinity DataKi:  1.64nMAssay Description:Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068564(1-(3,3-Dimethyl-2-oxo-butyryl)-piperidine-2-carbox...)
Affinity DataKi:  2nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068573(1-(2-Oxo-2-phenyl-acetyl)-piperidine-2-carboxylic ...)
Affinity DataKi:  3nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068582(1-(3,3-Dimethyl-2-oxo-butyryl)-piperidine-2-carbox...)
Affinity DataKi:  5nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116632(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  6nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi:  6nMAssay Description:Inhibition of GARFTase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116633(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  7nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23334(3-(pyridin-3-yl)propyl (2S)-1-(3,3-dimethyl-2-oxop...)
Affinity DataKi:  7.5nM ΔG°:  -42.5kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23334(3-(pyridin-3-yl)propyl (2S)-1-(3,3-dimethyl-2-oxop...)
Affinity DataKi:  7.5nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50277356(CHEMBL4168306)
Affinity DataKi:  8nMAssay Description:Inhibition of recombinant human AICARFTase using AICAR as substrate incubated at 37 degC for 30 mins measured after overnight incubation at 4 degCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068610(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  8.30nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116636(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  8.70nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116630(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  8.90nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116631(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113058(1-(Adamantan-1-ylcarbamoyl)-piperidine-2-carboxyli...)
Affinity DataKi:  12nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116635(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  12.2nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50289698(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  15nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068594(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  20nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113095((S)-1-Phenylmethanesulfonyl-pyrrolidine-2-carboxyl...)
Affinity DataKi:  22nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068591(1-(3,3-Dimethyl-2-oxo-butyryl)-piperidine-2-carbox...)
Affinity DataKi:  24nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068589(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  25nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23319(3,3-dimethyl-1-[(2S)-2-(5-phenylpentanoyl)pyrrolid...)
Affinity DataKi:  30nM ΔG°:  -39.3kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068572(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  30nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113063(1-(Adamantan-1-ylcarbamoyl)-piperidine-2-carboxyli...)
Affinity DataKi:  32nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113077(1-Phenylmethanesulfonyl-piperidine-2-carboxylic ac...)
Affinity DataKi:  47nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50344115(CHEMBL1777973 | N-((R)-6-(aminomethyl)-1,2,3,4-tet...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]-DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells membrane after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068596(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  60nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113070((S)-1-Cyclohexylthiocarbamoyl-pyrrolidine-2-carbox...)
Affinity DataKi:  86nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116637(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  86nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113056(1-Phenylmethanesulfonyl-piperidine-2-carboxylic ac...)
Affinity DataKi:  92nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113113((S)-1-Phenylmethanesulfonyl-piperidine-2-carboxyli...)
Affinity DataKi:  110nMAssay Description:Ability to inhibit peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113071(1-Phenylmethanesulfonyl-piperidine-2-carboxylic ac...)
Affinity DataKi:  120nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23322(3,3-dimethyl-1-[(2S)-2-{5-[2,3,5,6-tetrafluoro-4-(...)
Affinity DataKi:  130nM ΔG°:  -36.0kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23323(3,3-dimethyl-1-[(2S)-2-(4-phenylbutanoyl)pyrrolidi...)
Affinity DataKi:  180nM ΔG°:  -35.3kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113092(1-Benzenesulfonyl-piperidine-2-carboxylic acid 3-(...)
Affinity DataKi:  180nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23325(3,3-dimethyl-1-[(2S)-2-[5-(pyridin-3-yl)pentanoyl]...)
Affinity DataKi:  210nM ΔG°:  -34.9kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113091(1-(Toluene-4-sulfonyl)-piperidine-2-carboxylic aci...)
Affinity DataKi:  220nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23324(1-[(2S)-2-[5-(4-hydroxyphenyl)pentanoyl]pyrrolidin...)
Affinity DataKi:  240nM ΔG°:  -34.6kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068555(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  250nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113072(1-Benzenesulfonyl-piperidine-2-carboxylic acid 3-(...)
Affinity DataKi:  260nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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