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Found 2388 with Last Name = 'gupta' and Initial = 'k'
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50090023(4-(3,4-Difluoro-phenyl)-2-oxo-1,2,3,4-tetrahydro-p...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of [125I]L-762,459 from recombinant human alpha1a adrenergic receptor expressed in mammalian cells measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50090018(4-(3,4-Difluoro-phenyl)-2-oxo-1,2,3,4-tetrahydro-p...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [125I]L-762,459 from recombinant human alpha1a adrenergic receptor expressed in mammalian cells measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50090027((R)-4-(3,4-Difluoro-phenyl)-1,3,6-trimethyl-2-oxo-...)
Affinity DataKi:  0.140nMAssay Description:Displacement of [125I]L-762,459 from recombinant human alpha1a adrenergic receptor expressed in mammalian cells measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50245653(CHEMBL4100620)
Affinity DataKi:  0.160nMAssay Description:Displacement of [125I]L-762,459 from recombinant human alpha1a adrenergic receptor expressed in mammalian cells measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50090031(4-(3,4-Difluoro-phenyl)-2-oxo-1,2,3,4-tetrahydro-p...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [125I]L-762,459 from recombinant human alpha1a adrenergic receptor expressed in mammalian cells measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50245650(CHEMBL4062896)
Affinity DataKi:  0.170nMAssay Description:Displacement of [125I]L-762,459 from recombinant human alpha1a adrenergic receptor expressed in mammalian cells measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50245652(CHEMBL4081581)
Affinity DataKi:  0.180nMAssay Description:Displacement of [125I]L-762,459 from recombinant human alpha1a adrenergic receptor expressed in mammalian cells measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50090043(4-(3,4-Difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [125I]L-762,459 from recombinant human alpha1a adrenergic receptor expressed in mammalian cells measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50090013(4-(3,4-Difluoro-phenyl)-6-methoxymethyl-2-oxo-1,2,...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [125I]L-762,459 from recombinant human alpha1a adrenergic receptor expressed in mammalian cells measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50090041(6-(3,4-Difluoro-phenyl)-5-{3-[4-(4-fluoro-phenyl)-...)
Affinity DataKi:  0.75nMAssay Description:Displacement of [125I]L-762,459 from recombinant human alpha1a adrenergic receptor expressed in mammalian cells measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM282825(6-(4-(3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of TGFBR1 in human whole blood assessed as apparent inhibition constant by measuring reduction in TGFbeta-induced SMAD phosphorylationMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Mus musculus)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM282825(6-(4-(3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of TGFBR1 in mouse whole blood assessed as apparent inhibition constant by measuring reduction in TGFbeta-induced SMAD phosphorylationMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM198694(US9221796, 23b)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM198665(US9221796, 2b)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50090021(3-Acetyl-4-(3,4-difluoro-phenyl)-1,6-dimethyl-2-ox...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [125I]L-762,459 from recombinant human alpha1a adrenergic receptor expressed in mammalian cells measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM198728(US9221796, 46, P-4)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM198726(US9221796, 46, P-2)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50330324(CHEMBL4170867)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24732((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...)
Affinity DataKi:  6nM ΔG°:  -48.8kJ/mole IC50:  32nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM198728(US9221796, 46, P-4)
Affinity DataKi:  6.30nMAssay Description:Binding affinity to GluN2B receptor in human cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50458333(CHEMBL4210820)
Affinity DataKi:  7nMAssay Description:Non-competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50330409(CHEMBL4168402)
Affinity DataKi:  7.70nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50330410(CHEMBL4161899)
Affinity DataKi:  8.40nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24731((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...)
Affinity DataKi:  9nM ΔG°:  -47.8kJ/mole IC50:  51nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24734((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...)
Affinity DataKi:  11nM ΔG°:  -47.3kJ/mole IC50:  60nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM198735(US9221796, 48, P-3)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]Ro 25-6981 from GluN2B receptor in Sprague-Dawley rat forebrain membranes incubated for 1 hr by topcount micro scintillation coun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24746((2S)-6-amino-N-[(1S)-4-amino-1-{[(2S)-5-carbamimid...)
Affinity DataKi:  13nM ΔG°:  -46.8kJ/mole IC50:  73nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50245651(CHEMBL4071004)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]SNAP-7941 from recombinant human MCHR1 expressed in African green monkey COS7 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24739((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...)
Affinity DataKi:  19nM ΔG°:  -45.8kJ/mole IC50:  107nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24733((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...)
Affinity DataKi:  20nM ΔG°:  -45.7kJ/mole IC50:  112nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Banaras Hindu University

Curated by ChEMBL
LigandPNGBDBM50458333(CHEMBL4210820)
Affinity DataKi:  20nMAssay Description:Competitive inhibition of human MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH as substrate preincubated for 60 mins followed by substrate addition by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24735((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...)
Affinity DataKi:  26nM ΔG°:  -45.0kJ/mole IC50:  146nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24741((2S)-6-amino-N-[(2S)-5-carbamimidamido-1-oxopentan...)
Affinity DataKi:  28nM ΔG°:  -44.8kJ/mole IC50:  154nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24736(Capped tripeptide aldehyde inhibitor, 24 | benzyl ...)
Affinity DataKi:  40nM ΔG°:  -43.9kJ/mole IC50:  222nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24728((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...)
Affinity DataKi:  41nM ΔG°:  -43.9kJ/mole IC50:  231nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24744((2S)-N-[(1S)-5-amino-1-{[(2S)-5-carbamimidamido-1-...)
Affinity DataKi:  44nM ΔG°:  -43.7kJ/mole IC50:  245nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24742((2S)-6-amino-2-[(2S)-5-amino-2-(1-phenylacetamido)...)
Affinity DataKi:  46nM ΔG°:  -43.6kJ/mole IC50:  255nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24737((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...)
Affinity DataKi:  49nM ΔG°:  -43.4kJ/mole IC50:  271nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24748((2S)-2-[(2S)-6-amino-2-(1-phenylacetamido)hexanami...)
Affinity DataKi:  53nM ΔG°:  -43.2kJ/mole IC50:  297nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24745((2S)-6-amino-N-[(1S)-4-carbamimidamido-1-{[(2S)-5-...)
Affinity DataKi:  58nM ΔG°:  -43.0kJ/mole IC50:  325nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24738((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...)
Affinity DataKi:  81nM ΔG°:  -42.1kJ/mole IC50:  454nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24730((2S)-6-amino-2-[(2S)-6-amino-2-[(2E)-3-phenylprop-...)
Affinity DataKi:  104nM ΔG°:  -41.5kJ/mole IC50:  580nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24743((2S)-6-amino-N-[(2S)-5-carbamimidamido-1-oxopentan...)
Affinity DataKi:  111nM ΔG°:  -41.3kJ/mole IC50:  619nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50074933(2-biphenyl-4-yl-propionic acid | CHEMBL317434 | al...)
Affinity DataKi:  130nMAssay Description:Binding affinity of compound towards prostaglandin G/H synthase 1 was evaluatedMore data for this Ligand-Target Pair
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24740((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-5-carbamimid...)
Affinity DataKi:  160nM ΔG°:  -40.3kJ/mole IC50:  891nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50074922((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity of compound towards prostaglandin G/H synthase 1 was evaluatedMore data for this Ligand-Target Pair
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24747((2S)-6-amino-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-...)
Affinity DataKi:  2.07E+3nM ΔG°:  -33.7kJ/mole IC50:  1.16E+4nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1424-1463]/[1502-1685](West Nile virus (WNV))
University of Queensland

LigandPNGBDBM24749((2S)-6-amino-N-[(1S)-5-amino-1-{[(2S)-1-(1H-indol-...)
Affinity DataKi:  4.60E+3nM ΔG°:  -31.7kJ/mole IC50:  2.57E+4nMpH: 9.5 T: 2°CAssay Description:Inhibition of WNV protease activity was measured using recombinant WNV protease, which first incubated with inhibitor in 96-well plates. Catalysis wa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Technology And Science

Curated by ChEMBL
LigandPNGBDBM50272095(4-(3-(4-methoxyphenyl)-1H-indol-2-yl)benzenesulfon...)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Institute Of Technology And Science

Curated by ChEMBL
LigandPNGBDBM50272096(3-(4-methoxyphenyl)-2-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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