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Found 110 with Last Name = 'halgren' and Initial = 'ta'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM9291((3S,4aS,8aS)-N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of HIV-1 protease was determined in vitroChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM383((3S)-oxolan-3-yl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of HIV-1 protease was determined in vitroChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM842(Benzocycloalkyl Amines deriv. 12 | CHEMBL419923 | ...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1046(CHEMBL298316 | L-685,927 | tert-butyl N-[(2S,3S,5R...)
Affinity DataIC50:  0.160nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1039(CHEMBL297620 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.170nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035633(CHEMBL111143 | [(1S,2S,4R)-1-Benzyl-2-hydroxy-4-((...)
Affinity DataIC50:  0.180nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035635(CHEMBL322984 | [(1S,2S,4R)-1-Benzyl-4-((1S,2S,3R)-...)
Affinity DataIC50:  0.190nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003168(2-Benzyl-N-(6-cyclohexylmethyl-7-hydroxy-10-morpho...)
Affinity DataIC50:  0.200nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of HIV-1 protease was determined in vitroChecked by AuthorMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003195(CHEMBL126115 | [1-(6-Cyclohexylmethyl-7-hydroxy-10...)
Affinity DataIC50:  0.230nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1031(CHEMBL265514 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.230nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1030(CHEMBL296115 | L-685,434 | Urethane deriv. 1 | ter...)
Affinity DataIC50:  0.25nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035630(CHEMBL108918 | [(1S,2S,4R)-1-Benzyl-2-hydroxy-4-((...)
Affinity DataIC50:  0.25nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1040(CHEMBL296484 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.260nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1036(CHEMBL295904 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.270nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1038(CHEMBL265516 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.290nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1037(CHEMBL296493 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.310nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003191(CHEMBL338008 | [1-(6-Cyclohexylmethyl-7-hydroxy-10...)
Affinity DataIC50:  0.410nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003194(CHEMBL124616 | [1-(6-Cyclohexylmethyl-7-hydroxy-10...)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003174(CHEMBL339289 | {2-[1-(6-Cyclohexylmethyl-7-hydroxy...)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035628(CHEMBL430692 | [(1S,2S,4R)-1-Benzyl-2-hydroxy-4-((...)
Affinity DataIC50:  0.530nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1041(CHEMBL47514 | Hydroxyethylene dipeptide isostere 3...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003176(2-[1-(6-Cyclohexylmethyl-7-hydroxy-10-morpholin-4-...)
Affinity DataIC50:  0.600nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50422052(CHEMBL109952 | L-700417)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of HIV-1 protease was determined in vitroChecked by AuthorMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035631(CHEMBL325551 | [(1S,2S,4R)-1-Benzyl-2-hydroxy-4-((...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM1035(CHEMBL296855 | Hydroxyethylene dipeptide isostere ...)
Affinity DataIC50:  0.720nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005321(5-[2-(2-Acetylamino-3-phenyl-propionylamino)-hexan...)
Affinity DataIC50:  0.840nMpH: 7.4Assay Description:Compound was evaluated for the inhibition of human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003165(1N-[1-[12-cyclohexylmethyl-11-hydroxy-8-(1,4-oxazi...)
Affinity DataIC50:  1.10nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003181((diastereomer-1) (1-{6-Cyclohexylmethyl-7-hydroxy-...)
Affinity DataIC50:  1.30nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003181((diastereomer-1) (1-{6-Cyclohexylmethyl-7-hydroxy-...)
Affinity DataIC50:  1.30nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003192(2-(1-Aza-bicyclo[2.2.2]oct-3-ylamino)-N-(6-cyclohe...)
Affinity DataIC50:  1.30nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50422053(CHEMBL322037)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of HIV-1 protease was determined in vitroChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50230157(CHEMBL3144232)
Affinity DataIC50:  1.70nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005318(CHEMBL166771 | {1-[1-(4-Butylcarbamoyl-1-cyclohexy...)
Affinity DataIC50:  2.10nMpH: 7.4Assay Description:Compound was evaluated for the inhibition of human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003190((diastereomer-1)[1-(6-Cyclohexylmethyl-7-hydroxy-4...)
Affinity DataIC50:  3.40nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003177((diastereomer-1) [1-(6-Cyclohexylmethyl-7-hydroxy-...)
Affinity DataIC50:  3.90nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003188((diastereomer-1) [1-(6-Cyclohexylmethyl-10-dimethy...)
Affinity DataIC50:  3.90nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003177((diastereomer-1) [1-(6-Cyclohexylmethyl-7-hydroxy-...)
Affinity DataIC50:  3.90nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003188((diastereomer-1) [1-(6-Cyclohexylmethyl-10-dimethy...)
Affinity DataIC50:  3.90nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM9292((3S,4aS,8aS)-N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of HIV-1 protease was determined in vitroChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035634(CHEMBL268512 | [(1S,2S,4S)-1-Benzyl-2-hydroxy-4-((...)
Affinity DataIC50:  5.42nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003171((diastereomer-1) [1-(6-Cyclohexylmethyl-10-diethyl...)
Affinity DataIC50:  7nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003171((diastereomer-1) [1-(6-Cyclohexylmethyl-10-diethyl...)
Affinity DataIC50:  7nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50422049(CHEMBL322577)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of HIV-1 protease was determined in vitroChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035636(CHEMBL108960 | [(1S,2S,4R)-1-Benzyl-2-hydroxy-4-((...)
Affinity DataIC50:  7.70nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50035627(CHEMBL444057 | [(1S,2S,4R)-1-Benzyl-2-hydroxy-4-((...)
Affinity DataIC50:  9.53nMAssay Description:In vitro inhibition of HIV-1 proteaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003175(1H-Indole-2-carboxylic acid (6-cyclohexylmethyl-7-...)
Affinity DataIC50:  11nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003183((diastereomer-1)[1-(7-Cyclohexylmethyl-6-hydroxy-3...)
Affinity DataIC50:  17nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003183((diastereomer-1)[1-(7-Cyclohexylmethyl-6-hydroxy-3...)
Affinity DataIC50:  17nMpH: 7.4Assay Description:Inhibitory activity against human renin inhibition (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005312(5-[2-(3-Acetylamino-2-oxo-4-phenyl-piperidin-1-yl)...)
Affinity DataIC50:  21nMpH: 7.4Assay Description:Compound was evaluated for the inhibition of human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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