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Found 1211 with Last Name = 'handzlik' and Initial = 'j'
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50535225(CHEMBL4516622)
Affinity DataKi:  0.170nMAssay Description:Binding affinity to human H3RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]-prazosin from alpha1-adrenergic receptor in rat cerebral cortex membranes after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]-prazosin from alpha1-adrenergic receptor in rat cerebral cortex membranes after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50318633(3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEM...)
Affinity DataKi:  0.25nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50393167(CHEMBL2153721)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in rat brain cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50158595((4'-(3-((2R,5R)-2,5-dimethylpyrrolidin-1-yl)propox...)
Affinity DataKi:  0.420nMAssay Description:Binding affinity to human H3R expressed in rat C6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50044615(CHEMBL3329435)
Affinity DataKi:  0.530nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM34152(CHEMBL362628 | E-6801)
Affinity DataKi:  0.580nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50415977(CHEMBL1085113)
Affinity DataKi:  0.630nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]-LSD from human 5-HT6R expressed in human HeLa cells after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]iodoproxyfan from human full-length histamine H3 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50419052(SB-399885)
Affinity DataKi:  0.724nMAssay Description:Displacement of [3H]-LSD from human 5-HT6R expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50004518(CHEMBL2079256)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]-8-OH-DPAT from human recombinant 5-HT1A receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50019754(IDALOPIRDINE | LU-AE58054)
Affinity DataKi:  0.830nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H] raclopride from human recombinant D2L receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606660(CHEMBL5220473)
Affinity DataKi:  0.980nMAssay Description:Displacement of [125I]cAMP-tracer from 5-HT6R in human HeLa cells assessed as measuring cAMP level incubated for 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606652(CHEMBL5218527)
Affinity DataKi:  1nMAssay Description:Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50606653(CHEMBL5219333)
Affinity DataKi: <1nMAssay Description:Binding affinity to 5-HT1A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50044616(Cerlapirdine | PF-05212365 | SAM-531 | WAY-262531)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM30712(6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimet...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-clonidine from alpha2-adrenergic receptor in rat brain cortex after 30 mins by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human SERT assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50606655(CHEMBL5219924)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to D2R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50533199(CHEMBL4527011)
Affinity DataKi:  1.90nMAssay Description:Antagonist activity at human H3R expressed in rat C6 cells incubated for 20 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606655(CHEMBL5219924)
Affinity DataKi:  2nMAssay Description:Binding affinity to 5-HT2AR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606656(CHEMBL4117763)
Affinity DataKi:  2nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]-(R)alpha-MeHA from rat brain H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [125I]iodoproxyfan from human full-length histamine H3 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]-iodoproxyfan from human striatal full length H3 receptor after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50458523(JNJ-18038683)
Affinity DataKi:  3nMAssay Description:Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Polish Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM81790(Amisulpride | CAS_71675-85-9 | NSC_2159 | US101672...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]N-methyl-spiperone from D2R (unknown origin) assessed as inhibition constant by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50274767(CHEMBL4125735)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-LSD from human 5-HT6R expressed in human HEK293 cells incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50004756(CHEMBL3233679)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM81790(Amisulpride | CAS_71675-85-9 | NSC_2159 | US101672...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]N-methyl-spiperone from D3R (unknown origin) assessed as inhibition constant by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity to human 5-HT3R assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50004587(8-Adamantan-1-yl-1,3-dipropyl-3,7-dihydro-purine-2...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]CPX from adenosine A1 receptor in rat brain cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50524111(CHEMBL4452569)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50044601(CHEMBL3329445)
Affinity DataKi:  4nMAssay Description:Displacement of LSD from recombinant human 5-HT6R assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50004518(CHEMBL2079256)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50004518(CHEMBL2079256)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]prazosin from alpha1 adrenoceptor in rat cerebral cortex after 30 mins by microbeta scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50300828(2-(3-(3-fluorophenylsulfonyl)-1H-pyrrolo[2,3-b]pyr...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H] LSD from 5-HT6R in human HeLa cells assessed as inhibition constant incubated for 120 mins in presence of methiothepin by scinti...More data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50524116(CHEMBL4469847)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50176050(8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-1H-pu...)
Affinity DataKi:  5.15nMAssay Description:Displacement of [3H]MSX-2 from adenosine A2A receptor in rat brain striatal membraneMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50272040(CHEMBL4129950)
Affinity DataKi:  5.40nMAssay Description:Displacement of [125I]-Nalpha-MeHA from human H3 receptor expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50004520(CHEMBL3233401)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]-8-OH-DPAT from human recombinant 5-HT1A receptor expressed in HEK293 cell membrane after 1 hr by Microbeta scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor expressed in CHOK1 cells after 1 hr by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50569820(CHEMBL4860275)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK293 cells incubated for 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50569820(CHEMBL4860275)
Affinity DataKi:  6nMAssay Description:Binding affinity to human 5-HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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