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Found 1121 with Last Name = 'hangeland' and Initial = 'j'
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50448583(CHEMBL3127491)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032873(CHEMBL3355684)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis at 37 degC by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032873(CHEMBL3355684)
Affinity DataKi:  2nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50448583(CHEMBL3127491)
Affinity DataKi:  2nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214244(CHEMBL250978 | N-(5-((R)-4-((R)-1-(3,4-dimethoxyph...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032875(CHEMBL3355682)
Affinity DataKi:  3nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032876(CHEMBL3355681)
Affinity DataKi:  3nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103208(CHEMBL3393381)
Affinity DataKi:  3.20nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103201(CHEMBL3393388)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032877(CHEMBL3355680)
Affinity DataKi:  4nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  5nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214246(CHEMBL401135 | N-(5-((R)-4-((R)-1-(4-(difluorometh...)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214234(CHEMBL250755 | N-(5-((S)-3-((R)-2-(3-chlorophenyl)...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214213(CHEMBL399329 | N-(5-((S)-3-((R)-1-(3,4-dimethoxyph...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214242(CHEMBL447786 | N-(5-((R)-3-((S)-3-(2-chlorophenyl)...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214248(CHEMBL437578 | N-(5-((S)-3-((R)-2-(2-chlorophenyl)...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214240((R)-N-(2-hydroxy-5-(1-hydroxy-2-(2-(4-methoxypheny...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214237(CHEMBL400947 | N-(2-hydroxy-5-((S)-2-hydroxy-3-((R...)
Affinity DataKi:  8nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032876(CHEMBL3355681)
Affinity DataKi:  8nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103200(CHEMBL3393386)
Affinity DataKi:  8.40nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032878(CHEMBL3355679)
Affinity DataKi:  9nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214225(CHEMBL398557 | N-(5-((S)-3-((S)-1-(3,4-dimethoxyph...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214228(CHEMBL400067 | N-(5-((R)-3-((S)-1-(3,4-dimethoxyph...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50106810(CHEMBL317621 | N-(5-((R)-2-((R)-1-(3,4-dimethoxyph...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214227(CHEMBL251764 | N-(5-((R)-3-((S)-3-(4-chlorophenyl)...)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103216(CHEMBL3393373)
Affinity DataKi:  12nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103204(CHEMBL3393385)
Affinity DataKi:  13nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214233(CHEMBL250553 | N-(5-((S)-3-((R)-1-(3,4-bis(difluor...)
Affinity DataKi:  19nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032877(CHEMBL3355680)
Affinity DataKi:  20nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103206(CHEMBL3393383)
Affinity DataKi:  21nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50106829(BMS-196085 | CHEMBL322862 | N-(5-((R)-2-((R)-1-(4-...)
Affinity DataKi:  21nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypsin(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032874(CHEMBL3355683)
Affinity DataKi:  23nMAssay Description:Inhibition of human coagulation trypsin using N-benzoyl-Ile-Glu-(OH, OMe)-Gly-Arg-pNA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214245(CHEMBL429665 | N-(5-((S)-3-((R)-2-(4-chlorophenyl)...)
Affinity DataKi:  24nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103200(CHEMBL3393386)
Affinity DataKi:  24nMAssay Description:Inhibition of human plasma kallikreinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214225(CHEMBL398557 | N-(5-((S)-3-((S)-1-(3,4-dimethoxyph...)
Affinity DataKi:  24nMAssay Description:Displacement of [125I]iodocyanopindolol from human cloned adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214212(CHEMBL248548 | N-(5-((R)-3-((R)-1-(3,4-dimethoxyph...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214224(CHEMBL398241 | N-(5-((R)-3-((S)-3-(3-chlorophenyl)...)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]iodocyanopindolol from human cloned adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214224(CHEMBL398241 | N-(5-((R)-3-((S)-3-(3-chlorophenyl)...)
Affinity DataKi:  29nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032858(CHEMBL3355670)
Affinity DataKi:  30nMAssay Description:Inhibition of human coagulation factor 11a using p-nitroaniline as substrate assessed as substrate hydrolysis by spectrophotometricallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214223(CHEMBL251347 | N-(2-hydroxy-5-((R)-2-hydroxy-3-((S...)
Affinity DataKi:  31nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214231(CHEMBL249359 | N-(5-((S)-3-((R)-1-(3,4-dichlorophe...)
Affinity DataKi:  38nMAssay Description:Displacement of [125I]iodocyanopindolol from human cloned adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50103207(CHEMBL3393382)
Affinity DataKi:  42nMAssay Description:Inhibition of human coagulation factor 11a after 10 to 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032878(CHEMBL3355679)
Affinity DataKi:  45nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032875(CHEMBL3355682)
Affinity DataKi:  50nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214215(CHEMBL251581 | N-(2-hydroxy-5-((S)-2-hydroxy-3-((R...)
Affinity DataKi:  53nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214242(CHEMBL447786 | N-(5-((R)-3-((S)-3-(2-chlorophenyl)...)
Affinity DataKi:  57nMAssay Description:Displacement of [125I]iodocyanopindolol from human cloned adrenergic beta-2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50214220(CHEMBL251555 | N-(5-((R)-3-((S)-1-(3,4-bis(difluor...)
Affinity DataKi:  59nMAssay Description:Displacement of [125I]iodocyanopindolol from cloned human adrenergic beta-3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50032858(CHEMBL3355670)
Affinity DataKi:  60nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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