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Found 153 with Last Name = 'hao' and Initial = 'jj'
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284744(3-Allyloxycarbonylamino-5-[3-(1H-imidazol-2-yl)-na...)
Affinity DataKi:  90nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284735(3-Allyloxycarbonylamino-5-(3-carbamoyl-naphthalen-...)
Affinity DataKi:  320nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284734(3-Allyloxycarbonylamino-4-oxo-5-(3-phenylcarbamoyl...)
Affinity DataKi:  500nMAssay Description:Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284733(3-Allyloxycarbonylamino-5-(3-cyano-naphthalen-2-yl...)
Affinity DataKi:  620nMAssay Description:Binding affinity of the compound was determined against ETA receptor in porcine aortic smooth muscle membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284740(3-Allyloxycarbonylamino-5-(3-hydroxymethyl-naphtha...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProbable maltase-glucoamylase 2(Homo sapiens)
Ocean University Of China

Curated by ChEMBL
LigandPNGBDBM50457916(CHEBI:67537 | Terphenyllin)
Affinity DataKi:  1.50E+3nMAssay Description:Non-competitive inhibition of human alpha-glucosidase expressed in Saccharomyces cerevisiae using p-nitrophenyl-alpha-D-glucopyranoside as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50213208(CHEMBL3143890)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity of the compound was determined against ETA receptor in porcine aortic smooth muscle membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284745(3-Allyloxycarbonylamino-5-(4-carbamoyl-biphenyl-3-...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284741(3-(3-Allyloxycarbonylamino-4-carboxy-2-oxo-butoxy)...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284743(3-Allyloxycarbonylamino-4-oxo-5-phenoxy-pentanoic ...)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProbable maltase-glucoamylase 2(Homo sapiens)
Ocean University Of China

Curated by ChEMBL
LigandPNGBDBM50457899(CHEMBL4210494)
Affinity DataKi:  3.45E+3nMAssay Description:Non-competitive inhibition of human alpha-glucosidase expressed in Saccharomyces cerevisiae using p-nitrophenyl-alpha-D-glucopyranoside as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284727(3-Allyloxycarbonylamino-5-(3-cyclohexyl-propionylo...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284748(3-Allyloxycarbonylamino-5-(2-carbamoyl-phenoxy)-4-...)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284749(3-Allyloxycarbonylamino-5-(naphthalen-2-yloxy)-4-o...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284732(3-Allyloxycarbonylamino-4-oxo-5-phenethylamino-pen...)
Affinity DataKi:  4.40E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284739(3-[2-(2-Benzyloxycarbonylamino-3-methyl-butyrylami...)
Affinity DataKi:  4.90E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284747(3-Allyloxycarbonylamino-5-(naphthalen-1-yloxy)-4-o...)
Affinity DataKi:  9.50E+3nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284737(3-Allyloxycarbonylamino-5-(1-carbamoyl-naphthalen-...)
Affinity DataKi: >1.80E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284724(3-Allyloxycarbonylamino-4-oxo-5-(3-phenyl-propiony...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284736(3-Allyloxycarbonylamino-5-(2-carbamoyl-naphthalen-...)
Affinity DataKi: >2.20E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284722(3-Allyloxycarbonylamino-4-oxo-5-(3-phenoxy-propion...)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284718(3-Benzyloxycarbonylamino-4-oxo-5-(3-phenyl-propoxy...)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284726(3-Allyloxycarbonylamino-4-oxo-5-(3-phenyl-propylsu...)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284738(3-Allyloxycarbonylamino-5-(3-dimethylcarbamoyl-nap...)
Affinity DataKi: >2.80E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281182(3-(2-{2-[2-Acetylamino-3-(4-hydroxy-phenyl)-propio...)
Affinity DataKi:  4.20E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284731(3-Allyloxycarbonylamino-4-oxo-5-(3-phenyl-propylam...)
Affinity DataKi:  6.70E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284723(3-Allyloxycarbonylamino-5-(benzyl-phenethyl-amino)...)
Affinity DataKi:  6.80E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284729(3-Allyloxycarbonylamino-5-(1,2-diphenyl-ethylamino...)
Affinity DataKi:  7.00E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284725(3-Allyloxycarbonylamino-5-benzylcarbamoyloxy-4-oxo...)
Affinity DataKi:  7.40E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284719((S)-3-Allyloxycarbonylamino-4-oxo-5-[(E)-(3-phenyl...)
Affinity DataKi:  9.00E+4nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284730(3-Allyloxycarbonylamino-5-(benzhydryl-amino)-4-oxo...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284720(3-Allyloxycarbonylamino-4-oxo-8-phenyl-octanoic ac...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284721(3-Allyloxycarbonylamino-5-benzylamino-4-oxo-pentan...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284728(3-Allyloxycarbonylamino-5-(methyl-phenethyl-amino)...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284746(3-Allyloxycarbonylamino-6-[3-(1H-imidazol-2-yl)-na...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of IL-1 beta converting enzyme (ICE) in human blood monocytes expressed as KonMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193032(CHEMBL3979343 | US11155556, No. 2)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193014(CHEMBL3942643 | US11155556, No. 9)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM150175(US8980901, 107 | US9149477, Compound 107)
Affinity DataIC50:  2nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193032(CHEMBL3979343 | US11155556, No. 2)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193030(CHEMBL3950648 | US11155556, No. 14)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193017(CHEMBL3904942 | US11155556, No. 17)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50337135(4-((5,11-dimethyl-6-oxo-6,11-dihydro-5H-benzo[e]py...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193014(CHEMBL3942643 | US11155556, No. 9)
Affinity DataIC50:  11nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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