Affinity DataKi: 4.20nMAssay Description:Displacement of radiolabeled 4-(azetidin-1-yl)-3-[5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]-1-(tritritiomethyl)pyrazolo[3,4-d]pyrimidine from PD...More data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:Inhibition of PDE5A1 (unknwon origin) using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 0.370nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 0.420nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 0.790nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 0.920nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 1.29nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 1.41nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 1.54nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 3.40nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:The inhibition activity of 5-HT1A at 1 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 4.76nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 5.09nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.80nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:Inhibition of PDE5A1 (unknwon origin) using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
Affinity DataIC50: 9.70nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 11.5nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 11.7nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 11.9nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 27.2nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Affinity for adenosine A1 receptor using [3H]N6-(phenylisopropyl)adenosine (R)-[3H]-PIA as a radioligand in rat brain.More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 35nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
Affinity DataIC50: 109nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 115nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 146nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 189nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 241nMAssay Description:Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rattus norvegicus (rat))
Pfizer
Pfizer
Affinity DataIC50: 258nMpH: 7.5 T: 2°CAssay Description:PDE activity was measured using a plate-based Scintillation Proximity Assay (SPA). For competitive enzyme inhibition assays, the substrate [3H]cAMP c...More data for this Ligand-Target Pair