TargetProteasome subunit beta type-1(Homo sapiens (Human))
Institute Of Bio-Science And Technology
Curated by ChEMBL
Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataKi: 340nMAssay Description:Competitive inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate Linewea...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Institute Of Bio-Science And Technology
Curated by ChEMBL
Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataKi: 580nMAssay Description:Noncompetitive inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit assessed as hydrolysis of succinyl-LLVY-AMC fluorogeni...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Institute Of Bio-Science And Technology
Curated by ChEMBL
Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataKi: 670nMAssay Description:Competitive inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate Linewea...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Institute Of Bio-Science And Technology
Curated by ChEMBL
Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataKi: 870nMAssay Description:Noncompetitive inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit assessed as hydrolysis of succinyl-LLVY-AMC fluorogeni...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Institute Of Bio-Science And Technology
Curated by ChEMBL
Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataKi: 1.02E+3nMAssay Description:Competitive inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate Linewea...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Institute Of Bio-Science And Technology
Curated by ChEMBL
Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataKi: 1.10E+3nMAssay Description:Noncompetitive inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit assessed as hydrolysis of succinyl-LLVY-AMC fluorogeni...More data for this Ligand-Target Pair
Affinity DataKi: 2.74E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Oat1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.09E+3nMAssay Description:TP_TRANSPORTER: inhibition of Pravastatin uptake in Oat3-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5.28E+4nMAssay Description:TP_TRANSPORTER: inhibition of Pravastatin uptake in Oat3-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.18E+5nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Oat1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.15E+6nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake in Oat1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.35E+6nMAssay Description:TP_TRANSPORTER: inhibition of Pravastatin uptake in Oat3-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in baculovirus expression system using Ulight-GS peptide as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.330nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
Affinity DataIC50: 0.340nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
Affinity DataIC50: 0.340nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.360nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in baculovirus expression system using Ulight-GS peptide as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.470nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University
Curated by ChEMBL
Kyushu University
Curated by ChEMBL
Affinity DataIC50: 0.490nMAssay Description:Inhibition of recombinant human PDE4B using cAMP as substrate after 30 minsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University
Curated by ChEMBL
Kyushu University
Curated by ChEMBL
Affinity DataIC50: 0.490nMAssay Description:Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysisMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Institute Of Bio-Science And Technology
Curated by ChEMBL
Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...More data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.550nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.570nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.570nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.770nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.930nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.970nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.990nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.990nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...More data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of kinase tracer 236 binding to full length N terminal GST-tagged human CDK8 (1 to 464 end residues) /CycC ( 1 to 283 end residues) expres...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...More data for this Ligand-Target Pair