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Found 4060 with Last Name = 'hashimoto' and Initial = 'a'
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273464((1S,9S,10S)-11-(2-phenylethyl)-8-oxa-11-azatetracy...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]IOXY from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273935((4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-phenethy...)
Affinity DataKi:  26nMAssay Description:Displacement of [125I]IOXY from human recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273933((4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-phenethy...)
Affinity DataKi:  78nMAssay Description:Displacement of [125I]IOXY from human recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273935((4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-phenethy...)
Affinity DataKi:  190nMAssay Description:Displacement of [125I]IOXY from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273414((3R*,6aS*,11aR*)-1,3,4,5,6,11a-Hexahydro-2-pheneth...)
Affinity DataKi:  200nMAssay Description:Displacement of [125I]IOXY from human recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273414((3R*,6aS*,11aR*)-1,3,4,5,6,11a-Hexahydro-2-pheneth...)
Affinity DataKi:  560nMAssay Description:Displacement of [125I]IOXY from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273416((3R*,6aS*,11aR*)-1,3,4,5,6,11a-Hexahydro-2-pheneth...)
Affinity DataKi:  560nMAssay Description:Displacement of [125I]IOXY from human recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273415((3R*,6aS*,11aR*)-1,3,4,5,6,11a-Hexahydro-2-methyl-...)
Affinity DataKi:  620nMAssay Description:Displacement of [125I]IOXY from human recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273933((4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-phenethy...)
Affinity DataKi:  740nMAssay Description:Displacement of [125I]IOXY from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273934((4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-methyl-1...)
Affinity DataKi:  910nMAssay Description:Displacement of [125I]IOXY from human recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273416((3R*,6aS*,11aR*)-1,3,4,5,6,11a-Hexahydro-2-pheneth...)
Affinity DataKi:  1.22E+3nMAssay Description:Displacement of [125I]IOXY from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273416((3R*,6aS*,11aR*)-1,3,4,5,6,11a-Hexahydro-2-pheneth...)
Affinity DataKi:  2.53E+3nMAssay Description:Displacement of [125I]IOXY from human recombinant delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273415((3R*,6aS*,11aR*)-1,3,4,5,6,11a-Hexahydro-2-methyl-...)
Affinity DataKi:  2.78E+3nMAssay Description:Displacement of [125I]IOXY from human recombinant delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273414((3R*,6aS*,11aR*)-1,3,4,5,6,11a-Hexahydro-2-pheneth...)
Affinity DataKi:  2.84E+3nMAssay Description:Displacement of [125I]IOXY from human recombinant delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273415((3R*,6aS*,11aR*)-1,3,4,5,6,11a-Hexahydro-2-methyl-...)
Affinity DataKi: >2.93E+3nMAssay Description:Displacement of [125I]IOXY from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273934((4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-methyl-1...)
Affinity DataKi:  3.21E+3nMAssay Description:Displacement of [125I]IOXY from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273413((3R*,6aS*,11aR*)-1,3,4,5,6,11a-Hexahydro-2-methyl-...)
Affinity DataKi:  3.43E+3nMAssay Description:Displacement of [125I]IOXY from human recombinant delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273935((4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-phenethy...)
Affinity DataKi:  3.71E+3nMAssay Description:Displacement of [125I]IOXY from human recombinant delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273933((4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-phenethy...)
Affinity DataKi:  4.76E+3nMAssay Description:Displacement of [125I]IOXY from human recombinant delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273413((3R*,6aS*,11aR*)-1,3,4,5,6,11a-Hexahydro-2-methyl-...)
Affinity DataKi:  4.82E+3nMAssay Description:Displacement of [125I]IOXY from human recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273413((3R*,6aS*,11aR*)-1,3,4,5,6,11a-Hexahydro-2-methyl-...)
Affinity DataKi: >8.00E+3nMAssay Description:Displacement of [125I]IOXY from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273932((4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-methyl-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]IOXY from human recombinant delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273934((4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-methyl-1...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [125I]IOXY from human recombinant delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273932((4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-methyl-1...)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [125I]IOXY from human recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50273932((4R*,6aS*,11bR*)-2,3,4,5,6,6a-Hexahydro-3-methyl-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]IOXY from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(Homo sapiens (Human))
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50173539(1-(4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-...)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of human dUTPase assessed as production of [5-3H]dUMP from [5-3H]dUTP after 15 mins measured by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM149712(US8975409, Example 9)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Rattus norvegicus (Rat))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50143197(CHEMBL3759037)
Affinity DataIC50:  3.60nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065611(CHEMBL3401383)
Affinity DataIC50:  3.70nMAssay Description:Displacement of [33P]S1P from human S1P2 expressed in CHO-K1 cells by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50143192(CHEMBL3758929)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Rattus norvegicus (Rat))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50120582(CHEMBL3618199)
Affinity DataIC50:  4.60nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Rattus norvegicus (Rat))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50065611(CHEMBL3401383)
Affinity DataIC50:  4.80nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM149709(US8975409, Example 19)
Affinity DataIC50:  5.20nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Rattus norvegicus (Rat))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50120583(CHEMBL3618200)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50:  6.20nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM149705(US8975409, Example 9(3))
Affinity DataIC50:  6.20nMAssay Description:Antagonist activity at human S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50143201(CHEMBL3759864)
Affinity DataIC50:  6.40nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50143203(CHEMBL3759434)
Affinity DataIC50:  8.20nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50131845(CHEMBL3633535)
Affinity DataIC50:  8.60nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50143202(CHEMBL3758872)
Affinity DataIC50:  8.80nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50143206(CHEMBL3759532)
Affinity DataIC50:  8.80nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50143200(CHEMBL3758775)
Affinity DataIC50:  9.30nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50131854(CHEMBL3633526)
Affinity DataIC50:  9.30nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50131853(CHEMBL3633527)
Affinity DataIC50:  11nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50143198(CHEMBL3758974)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50131859(CHEMBL3633537)
Affinity DataIC50:  12nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50143191(CHEMBL3758214)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Rattus norvegicus (Rat))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50120579(CHEMBL3618196)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at rat S1P2 expressed in CHO cells assessed as Ca2+ level by FURA-2AM dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50131855(CHEMBL3633366)
Affinity DataIC50:  14nMAssay Description:Binding affinity against delta opioid receptor in mouse hot plate testMore data for this Ligand-Target Pair
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